Prevalence of Atrial Fibrillation in Hospital Encounters With End-Stage COPD on Home Oxygen

Xiao, Xiaochun; Han, Hedong; Wu, Cheng; He, Qian; Ruan, Yijun; Zhai, Yinghong; Gao, Yongqing; Zhao, Xiaofeng; He, Jia

doi:10.1016/j.chest.2018.12.021

Cited by 26 publications

(33 citation statements)

References 31 publications

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“…This quantitative difference might lie in a higher severity of liver disease in our study, namely ESLD or decompensated cirrhosis. It has been previously well established that age, sex, race, income and insurance differences exist in AF prevalence in the general population or specific conditions like acute ischaemic stroke and end‐stage chronic obstructive pulmonary disease . Consistent with other studies, we found that advancing age, male, white race, higher income and Medicare insurance were related to increased AF occurrence.…”

Section: Discussionsupporting

confidence: 90%

“…It has been previously well established that age, sex, race, income and insurance differences exist in AF prevalence in the general population or specific conditions like acute ischaemic stroke and end-stage chronic obstructive pulmonary disease. [33][34][35] Consistent with other studies, 17,19 we found that advancing age, male, white race, higher income and Medicare insurance were related to increased AF occurrence. More studies regarding these disparities are needed to provide further explanation.…”

Section: Discussionsupporting

confidence: 90%

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Atrial fibrillation in hospitalized patients with end‐stage liver disease: temporal trends in prevalence and outcomes

Han

Qin

et al. 2019

Liver International

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Background & Aims End‐stage liver disease (ESLD) happens due to the development and progression of chronic liver disease. This study aims to investigate the temporal trend, patient characteristics and outcomes of atrial fibrillation (AF) in hospitalized ESLD patients across the United States. Methods Nationwide Inpatient Sample from 2003 to 2014 was utilized to retrospectively study the weighted prevalence of AF in hospitalized ESLD patients. Multivariable regression models were used to assess the association between AF with clinical factors, in‐hospital mortality, length of stay (LOS) and cost. Results 639 345 hospitalizations associated with ESLD were identified, of which 47 710 (7.48%) were diagnosed with AF. The prevalence of AF increased from 5.73% in 2003 to 9.75% in 2014 in ESLD and varied by age, race, income, insurance type and hospital characteristics. Factors associated with AF included advancing age, male, white race, high income and urban teaching hospital. AF presence was associated with significant higher in‐hospital mortality (odds ratio, 1.40; 95% confidence interval, 1.35‐1.45), 21% longer LOS and 22% higher cost. In addition, a significant decreasing trend in in‐hospital mortality was observed (from 16.70% to 10.63% in patients with AF and from 10.74% to 7.50% in patients without AF). Conclusions The prevalence of AF in hospitalized ESLD patients has continued to increase from 2003 through 2014. AF is associated with poor prognosis and higher health resource utilization. Innovative anticoagulation strategies through improved collaboration between cardiologists and hepatologists are required for better management of hospitalized ESLD patients comorbid with AF.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Atrial fibrillation in hospitalized patients with end‐stage liver disease: temporal trends in prevalence and outcomes

Han

Qin

et al. 2019

Liver International

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“…In the present study, 5 patients with AF were more likely to be older (age $ 75 years), male, white, and have a higher CHA 2 DS 2 -VASc (congestive heart failure, hypertension, age $ 75 years, diabetes mellitus, stroke/ transient ischemic attack, vascular disease, age 65-74 years, sex category) score. Although the authors did not report whether the latter was predictive of AF, the associations between COPD, higher CHA 2 DS 2 -VASc scores, and incident AF are well recognized.…”

mentioning

confidence: 53%

“…What are the practical implications of this study 5 consequently, a late diagnosis and delayed treatment initiation of AF may worsen outcomes in these patients. Conversely, the selective application of smart monitoring devices in patients with increased risk might improve the treatment outcomes through earlier diagnosis and timely management, as is advocated in those with cryptogenic stroke.…”

mentioning

confidence: 96%

“…In this issue of CHEST, Xiao et al 5 analyzed and reported AF prevalence and its trends over time from a long-term nationwide database of patients with end-stage COPD reliant on home oxygen therapy in the United States. As expected, the overall prevalence of AF continuously increased, from 12.9% to 21.3%, over the study period, and AF was significantly associated with higher inhospital death, stroke, mechanical ventilation, increased costs, and longer hospital stays, even after adjustment.…”

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confidence: 99%

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Atrial Fibrillation and End-Stage COPD

Shin

Manuel

Lip

2019

Chest

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Prevalence, trends, and outcomes of atrial fibrillation in hospitalized patients with metastatic cancer: findings from a national sample

et al. 2021

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Background Epidemiological evidence regarding the link between cancer and atrial fibrillation (AF) are limited and outcomes of metastatic cancer comorbid with AF need to be elucidated. Objective This study aims to evaluate the prevalence, temporal trends, and outcomes of AF in hospitalized metastatic cancer patients. Methods The National Inpatient Sample (NIS) database was used to identify adult patients with metastatic tumors from 2003 to 2014. We analyzed the trends in AF prevalence, in‐hospital mortality, total cost, length of stay (LOS), and comorbidities pertaining to metastatic cancer. Multivariable‐adjusted models were used to evaluate the association of AF with clinical factors, in‐hospital mortality, total cost, and LOS. Results Among 2,478,598 patients with metastatic cancer, 8.74% (216,737) were diagnosed with AF. The proportion of comorbid AF increased from 8.28% in 2003 to 10.06% in 2014 (p < 0.0001). Older age, white race, male, Medicare, higher income, larger hospital bed size, and urban teaching hospital were associated with higher AF occurrence. Among primary tumor sites, lung cancer experienced the highest odds of AF compared to other cancers. Patients with metastasis to lymph node and respiratory organ had higher odds of AF. In metastatic cancer, AF was associated with higher in‐hospital mortality (odds ratio: 1.48; 95% confidence interval: 1.43–1.54), 18% longer LOS, and 19% higher cost. Conclusions AF prevalence in metastatic cancer continues to increase from 2003 to 2014. AF is linked to poorer prognosis and higher healthcare resource utilization. As the population ages, optimal preventive and treatment management strategies are needed for metastatic cancer comorbid with AF.

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Prevalence of Atrial Fibrillation in Hospital Encounters With End-Stage COPD on Home Oxygen

Cited by 26 publications

References 31 publications

Atrial fibrillation in hospitalized patients with end‐stage liver disease: temporal trends in prevalence and outcomes

Atrial fibrillation in hospitalized patients with end‐stage liver disease: temporal trends in prevalence and outcomes

Atrial Fibrillation and End-Stage COPD

Prevalence, trends, and outcomes of atrial fibrillation in hospitalized patients with metastatic cancer: findings from a national sample

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