Prevalence of autism spectrum disorder in Asia: A systematic review and meta-analysis

Qiu, Shuang; Lu, Yingjie; Li, Yan; Shi, Jingwei; Cui, Heran; Gu, Yan; Li, Yong; Zhong, Weijing; Zhu, Xiaojuan; Liu, Yunkai; Yi, Cheng; Liu, Yawen; Qiao, Yichun

doi:10.1016/j.psychres.2019.112679

Cited by 120 publications

(71 citation statements)

References 36 publications

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“…Qiu et al [48] have published a systematic review and meta-analysis of studies on prevalence of ASD in South Asia ( [29] evaluated ASD prevalence in children aged 6 to 11 years from two mainstream schools in Beijing, yielding an estimate of 11.9/1000. In 2019, Sun et al [30] estimated ASD prevalence in three cities (Jilin, Shenzhen, and Jiamusi) at December 2013, using data from mainstream school only in all the cities and from the whole population in Jilin.…”

Section: Asiamentioning

confidence: 99%

Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014

2020

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The prevalence of Autism Spectrum Disorder (ASD) has increased dramatically in recent decades, supporting the claim of an autism epidemic. Systematic monitoring of ASD allows estimating prevalence and identifying potential sources of variation over time and geographical areas. At present, ASD prevalence estimates are available worldwide, coming either from surveillance systems using existing health and educational databases or from population studies specifically performed. In the present article, we present a review of the ASD prevalence estimates published since 2014. Data confirm a high variability in prevalence across the world, likely due to methodological differences in case detection, and the consistent increase of prevalence estimates within each geographical area.

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Section: Asiamentioning

confidence: 99%

Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014

2020

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“…While in the United Kingdom, the annual prevalence rate for children aged 8 years between 2004 and 2010 was 3.8/1000 for boys and 0.8/1000 for girls 3 . Recent studies have shown that the pooled ASD prevalence estimate in Asia is 0.36%, including data from nine countries (China, Korea, India, Bangladesh, Lebanon, Iran, Israel, Nepal and Sri Lanka) 4 . The prevalence of ASD in the Middle East region was documented to be 1.4 per 10,000 children in Oman 5 , 4.3 per 10,000 children in Bahrain 6 , 1/167 in Saudi Arabia 7 , and a recent study reported ASD prevalence to be 1.14 % in children aged 6-11 years in Qatar 8 .…”

Section: Introductionmentioning

confidence: 99%

Genetics of structural and functional brain changes in autism spectrum disorder

et al. 2020

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Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context of other neurological, psychiatric, developmental, and genetic disorders. Due to rapid developments in genomics and imaging technologies, imaging genetics studies of ASD have evolved in the last few years. Increased risk for ASD diagnosis is found to be related to many specific single-nucleotide polymorphisms, and the study of genetic mechanisms and noninvasive imaging has opened various approaches that can help diagnose ASD at the nascent level. Identifying risk genes related to structural and functional changes in the brain of ASD patients provide a better understanding of the disease's neuropsychiatry and can help identify targets for therapeutic intervention that could be useful for the clinical management of ASD patients.

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“…A project funded by the European Parliament and managed by the European Commission reported in December 2018 that the prevalence of ASD in Europe ranged from 4.4 to 19.7 per 1000 children aged 7–9 years old, with an averaged estimated prevalence of 12.2 per 1000 (or 1 in 89 children) ( ). A recent meta-analysis of literature published up to August 6, 2018, concluded that the pooled estimated of ASD prevalence in Asia was 3.6% (95% CI: 0.16–0.79%) [ 3 ]. Large-scale surveys estimate the median worldwide prevalence of ASD to be 1–2% [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?

Panesar

Kennedy

Stietz

et al. 2020

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Autism spectrum disorder (ASD) includes a group of multifactorial neurodevelopmental disorders defined clinically by core deficits in social reciprocity and communication, restrictive interests and repetitive behaviors. ASD affects one in 54 children in the United States, one in 89 children in Europe, and one in 277 children in Asia, with an estimated worldwide prevalence of 1–2%. While there is increasing consensus that ASD results from complex gene x environment interactions, the identity of specific environmental risk factors and the mechanisms by which environmental and genetic factors interact to determine individual risk remain critical gaps in our understanding of ASD etiology. Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that have been linked to altered neurodevelopment in humans. Preclinical studies demonstrate that PCBs modulate signaling pathways implicated in ASD and phenocopy the effects of ASD risk genes on critical morphometric determinants of neuronal connectivity, such as dendritic arborization. Here, we review human and experimental evidence identifying PCBs as potential risk factors for ASD and discuss the potential for PCBs to influence not only core symptoms of ASD, but also comorbidities commonly associated with ASD, via effects on the central and peripheral nervous systems, and/or peripheral target tissues, using bladder dysfunction as an example. We also discuss critical data gaps in the literature implicating PCBs as ASD risk factors. Unlike genetic factors, which are currently irreversible, environmental factors are modifiable risks. Therefore, data confirming PCBs as risk factors for ASD may suggest rational approaches for the primary prevention of ASD in genetically susceptible individuals.

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Prevalence of autism spectrum disorder in Asia: A systematic review and meta-analysis

Cited by 120 publications

References 36 publications

Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014

Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014

Genetics of structural and functional brain changes in autism spectrum disorder

Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?

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