Prevalence of autoimmune thyroiditis and non-immune thyroid disease in multiple sclerosis

Niederwieser, Gerald; Buchinger, W.; Bonelli, Raphael M.; Berghold, Andrea; Reisecker, F; Költringer, P; Archelos, Juan J.

doi:10.1007/s00415-003-1053-9

Cited by 74 publications

(40 citation statements)

References 27 publications

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“…Hypothyroidism caused by Hashimoto thyroiditis displays a tendency to be more severe and more common in MS patients (5).…”

Section: Resultsmentioning

confidence: 99%

Multiple sclerosis and thyroid gland diseases

Drenska

2016

SSM

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Multiple sclerosis (MS) often presents with accompanying diseases. Thyroid gland pathology is not a rare finding in MS patients. Among a hospital cohort of 335 MS patients, 16 females with five thyroid gland diseases were diagnosed during a 14-year period. There were six cases of diffuse goiter, four of postoperative hypothyroidism, three of thyroid adenoma, two of autoimmune thyroiditis, and one of hyperthyroidism. The age characteristics of the patients varied for the specific diseases. We emphasize the need for regular monitoring of the thyroid function in MS patients.

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“…Hypothyroidism caused by Hashimoto thyroiditis displays a tendency to be more severe and more common in MS patients (5).…”

Section: Resultsmentioning

confidence: 99%

Multiple sclerosis and thyroid gland diseases

Drenska

2016

SSM

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“…38 antiTPO sentezinden sorumlu olabileceği öne sü-rülmektedir. MS hastalarında tiroid antikoru yük-sekliği görülme oranı ise %4-22 arasında değiş-mektedir.…”

Section: Discussionunclassified

Antigliadin Antibodies and Multiple Sclerosis

Türkoğlu¹,

Çömez²,

Gençer³

et al. 2010

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Multipl skleroz (MS) ve çölyak hastalığı immun aracılı hastalıklardır. Gluten duyarlılığı, genetik yatkınlığı olan kişilerde buğday gliadini başta olmak üzere belli tahıl proteinlerinin alınmasıyla tetiklenen immunolojik bir reaksiyondur. Antigliadin antikorları da bu reaksiyonun göstergesidir. Periferik nöropati, serebellar ataksi ve artmış epilepsi riski gluten hassasiyetinin nörolojik komplikasyonlarıdır. Bu sebeple antigliadin antikorlarını MS hastalarında ölçmeye karar verdik. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalış-mada Haydarpaşa Numune Eğitim ve Araştırma Hastanesi II. Nöroloji kliniği MS polikliniğinden takip edilen, 50 MS hastası ile bilinen bir sistemik hastalığı olmayan 52 gönüllü karşılaştırıldı. Antigliadin antikoru (AGA) IgG ve IgA bütün hastalarda çalışıldı. Antiendomisyal antikor (AEA) ise çölyak ayırıcı tanısı için AGA pozitif hastalarda bakıldı. B Bu ul lg gu ul la ar r: : Antigliadin antikoru (AGA) IgG'nin, %30, AGA IgA'nın %12 hastada pozitif olduğu; AEA'nın bakılan tüm hastalarda negatif olduğu saptandı. Kontrol grubunda ise AGA IgG ve IgA %25 ve %7.6 oranında pozitifti. MS ve kontrol grubunda AGA IgG ve IgA sonuçları arasında bir fark görülmedi. IgG ve IgA AGA pozitif olan bütün hastalarda AEA ve histopatolojik çalışma negatifti. Farklı cinsiyet, yaş, klinik seyir ve fonksiyonel tutulumu olan MS hastalarının ortalama AGA IgG ve IgA düzeylerinde anlamlı bir fark yoktu. S So on nu uç ç: : Sistemik otoimmün hastalığa ve immun disfonksiyona yol açmayan, klinik olarak anlam ifade etmeyen otoantikorlar, immünolojik kaskadı bozabilirler. Fakat immün disregülasyona sekonder olarak MS hastalarında diğer otoantikorlarla birlikte antigliadin antikorları da yüksek oranda bulunabilir. Ama bu bulgu anlamlı değildir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Multipl skleroz; otoimmünite; antikor afinitesi; otoantikor; antikor oluşumu A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Multiple sclerosis (MS) and celiac disease are both considered as immune-mediated disorders. The term gluten sensitivity refers to a state of increased immunological responsiveness to ingested gluten in genetically susceptible individuals, as indicated by circulating antibodies to gliadin. Several neurological complications have been described associated with gluten sensitivity ranging from peripheral neuropathy and cerebellar ataxia to an increased risk of epilepsy. So, we decided to measure these antibodies in serum of MS patients. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Fifty MS patients were randomly recruited from MS clinics of Haydarpaşa Numune Training and Research Hospital IInd Neurology Clinic and compared with a control group of 52 healthy volunteers. Antigliadin antibody (AGA) IgG and IgA levels were studied in all patients. Antiendomisial antibody (AEA) in serum was studied in patients who have positive antigliadin antibody for differential diagnosis of celiac disease. R Re es su ul lt ts s: : AGA IgG and AGA IgA were posi...

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“…In particular it was demonstrated that males with MS have the same prevalence of thyroid disorders as women, with or without MS [8]. At baseline alterations of thyroid hormones and/or thyroid stimulating hormon (TSH) were observed in 5.3% of patients [7].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Parameters Alterations in Multiple Sclerosis: A Longitudinal Study and Review of the Literature

Orefice

Ferraro²,

Barbato³

et al. 2012

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Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and is characterized by inflammation, demyelination and desctruction of oligodendrocytes and axons. The immunology of MS is complex, involving autoreactive Th1 and Th17 lymphocytes, cells of the innate immune system including dedritic, natural killer (NK) and microglia cells, as well as vascular endothelial cells. Multiple Sclerosis (MS) is based by a series of biochemical changes affecting to different extent neuronal functions; great attention has been focused on: liver enzymes, thyroid function tests, autoantibodies, lipid profile and uric acid levels. Following the introduction of therapy with drugs that modify the course of disease, more attention has been paid to the change of biochemical parameters, in particular to evaluate possible adverse effects. Aim of this study was to perform a review of the literature on biochemical alterations in treated and untreated MS patients and to assess laboratory parameters alterations in a cohort of MS patients, before and during treatment. On a total of 624 patients followed at our center, we selected those who practiced for the first time a therapy with IFN beta 1a at various doses, IFN beta 1b and Glatiramer acetate, that were 595 (95%), with baseline biochemical evaluation available in 488 (82%) (307 females, mean age 36.6 years). We considered the evolution of various biochemical parameters during treatment. The following outcome variables were evaluated: laboratory changes, in particular liver function, thyroid function, lipids and blood cell count. Percentages were compared using the chisquare test. ANOVA was performed to evaluate changes of laboratory tests over time between therapy groups. Our finding confirm the presence of biochemical alterations at baseline, in particular regarding liver enzymes, thyroid hormones and lipids. Treatment effects were more evident on liver enzymes elevation, anti thyroid antibodies production and blood cholesterol decrease. These effects were mainly transient and self remitting without suspension of therapy. Biochemical alterations, mainly related to autoimmune pathology and lipid metabolism change were encountered. Treatments increased transient biochemical alterations particulary in patients with baseline changes, suggesting a stricter monitoring of blood exams in this category of patients.

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Prevalence of autoimmune thyroiditis and non-immune thyroid disease in multiple sclerosis

Cited by 74 publications

References 27 publications

Multiple sclerosis and thyroid gland diseases

Multiple sclerosis and thyroid gland diseases

Antigliadin Antibodies and Multiple Sclerosis

Biochemical Parameters Alterations in Multiple Sclerosis: A Longitudinal Study and Review of the Literature

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