Prevalence of bacterial vaginosis and its risk factors in HIV/AIDS patients with abnormal vaginal discharge

Nwadioha, S. I.; Egah, DZ; Banwat, E.B; Egesie, Julie O; Onwuezobe, Ifeanyi A

doi:10.1016/s1995-7645(11)60059-x

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…6 In women with trichomoniasis, there is a risk of co-infection with BV. 70 A study conducted by Abbai et al (2016) in South African women showed a significant association between baseline BV infections and incident T. vaginalis infections. 71 Cervical cancer is the most common cause of cancer-related deaths in young women from sub-Saharan Africa.…”

Section: Africamentioning

confidence: 99%

A review on Trichomonas vaginalis infections in women from Africa

Mabaso

Abbai

2021

Southern African Journal of Infectious Diseases

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Despite being a highly prevalent infection in the African continent, there is no review article published that solely focusses on Trichomonas vaginalis (T. vaginalis) infections in women from Africa. This review aims to fill this gap in the literature.Method: An electronic search of online databases was used to identify and extract relevant research articles related to the epidemiology, health complications and treatment associated with T. vaginalis in women from Africa.Results: Within the African continent, South Africa has reported the highest prevalence rate for this infection. A combination of sociodemographic, behavioural and biological factors has been shown to be associated with infection. Trichomonas vaginalis infection is associated with the acquisition of HIV, cervical cancer and PIDs in various female populations across the continent. Emerging patterns of resistance to metronidazole have been reported in women from South Africa. Currently, there is no effective vaccine against this pathogen despite efforts at vaccine development. Conclusion:Based on the high prevalence and health consequences associated with T. vaginalis, there is a need for improved screening programmes that will lead to early diagnosis, detection of asymptomatic infections and effective treatment regimens.

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Section: Africamentioning

confidence: 99%

A review on Trichomonas vaginalis infections in women from Africa

Mabaso

Abbai

2021

Southern African Journal of Infectious Diseases

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“…The literature review identified 108 articles that associated sexually transmitted infections with HIV‐infected women. Among these articles, 33 were chosen based on the abstract and 9 were excluded owing to the criteria given above, leaving 24 articles in the analysis . The results from these articles on the influence of HIV on the prevalence, course, and treatment of other sexually transmitted infections are synthetized in Table .…”

Section: Literature Summarymentioning

confidence: 99%

“…The prevalence of bacterial vaginosis is 36%–43% and is similar in women infected or uninfected with HIV . Vaginal infections are more frequent in women carrying the virus …”

Section: Literature Summarymentioning

confidence: 99%

Women infected with HIV and the impact of associated sexually transmitted infections

Reda

Gonçalves

Mazepa

et al. 2018

Intl J Gynecology & Obste

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“…Both HSV-2 and Chlamydia trachomatis infection increase the number of α4β7+ CD4+ T cells in the genital tissue [ 7 , 30 , 42 ]. Bacterial vaginosis, a common syndrome characterised by a shift in vaginal flora composition [ 43 ], has been identified as a specific risk factor for HIV acquisition, also influencing genital tract cytokine concentrations [ 40 , 44 , 45 ]. In this study, we found that BV diagnosis at the time of HIV infection was associated with T/F viruses that had high α4β7 dependence for replication, but found no such associations with STI’s.…”

Section: Discussionmentioning

confidence: 99%

South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication

et al. 2015

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BackgroundThe integrin α4β7 mediates the trafficking of immune cells to the gut associated lymphoid tissue (GALT) and is an attachment factor for the HIV gp120 envelope glycoprotein. We developed a viral replication inhibition assay to more clearly evaluate the role of α4β7 in HIV infection and the contribution of viral and host factors.ResultsReplication of 60 HIV-1 subtype C viruses collected over time from 11 individuals in the CAPRISA cohort were partially inhibited by antibodies targeting α4β7. However, dependence on α4β7 for replication varied substantially among viral isolates from different individuals as well as over time in some individuals. Among 8 transmitted/founder (T/F) viruses, α4β7 reactivity was highest for viruses having P/SDI/V tri-peptide binding motifs. Mutation of T/F viruses that had LDI/L motifs to P/SDI/V resulted in greater α4β7 reactivity, whereas mutating P/SDI/V to LDI/L motifs was associated with reduced α4β7 binding. P/SDI/V motifs were more common among South African HIV subtype C viruses (35%) compared to subtype C viruses from other regions of Africa (<8%) and to other subtypes, due in part to a founder effect. In addition, individuals with bacterial vaginosis (BV) and who had higher concentrations of IL-7, IL-8 and IL-1α in the genital tract had T/F viruses with higher α4β7 dependence for replication, suggesting that viruses with P/SDI/V motifs may be preferentially transmitted in the presence of BV in this population.ConclusionsCollectively, these data suggest a role for α4β7 in HIV infection that is influenced by both viral and host factors including the sequence of the α4β7 binding motif, the cytokine milieu and BV in the genital tract. The higher frequency of P/SDI/V sequences among South African HIV-1 subtype C viruses may have particular significance for the role of α4β7 in this geographical region.Electronic supplementary materialThe online version of this article (doi:10.1186/s12977-015-0183-3) contains supplementary material, which is available to authorized users.

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Prevalence of bacterial vaginosis and its risk factors in HIV/AIDS patients with abnormal vaginal discharge

Abstract: There was a significant statistical difference in prevalence of bacterial vaginosis between the HIV/AIDS group and non-HIV(control) group of patients in the study. Risk behaviors that promote the incidence of bacterial vaginosis should be especially paid attention.

Cited by 8 publications

References 7 publications

A review on Trichomonas vaginalis infections in women from Africa

A review on Trichomonas vaginalis infections in women from Africa

Women infected with HIV and the impact of associated sexually transmitted infections

South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication

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