Prevalence of Balkan Endemic Nephropathy Has Not Changed Since 1971 in the Kolubara Region in Serbia

Bukvić, Danica; Marić, Ivko; Arsenović, Aleksandra; Janković, Slavenka; Djukanović, Ljubica

doi:10.1159/000101447

Cited by 27 publications

(26 citation statements)

References 25 publications

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“…11 Screening studies carried out in villages affected by BEN in Serbia found prevalence rate of BEN between 1.7% and 8.9%. 12,13 Although data on kidney and urinary tract disease prevalence in the examined enclave could not be compared with these data, they indicated that these two communities might be placed among those with a high prevalence of kidney disease. In support of this is a positive family history for kidney disease as reported by 27% of all the Notes: eGFR calculated by MDRD; alpha1MG-urine, alpha1-microglobulin, NAG, N-acetyl-b-D-glucosaminidase; AP, urine alkaline phosphatase.…”

Section: Discussionmentioning

confidence: 97%

High prevalence of kidney disease in two rural communities in Kosovo and Metohia

Stašević¹,

Gorgieva²,

Vasić³

et al. 2010

Renal Failure

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A systematic survey was carried out in an enclave in Kosovo and Metohia, with the aim of assessing the prevalence of kidney diseases. The survey involved 423 (180 males) adult inhabitants from two small settlements, Velika Ho0a and Orahovac, and included an interview, medical documentation, physical, ultrasound, and laboratory examinations. Persons with any detected disorder indicating kidney disease were invited for additional examination of kidney function. Using urine dipstick test, proteinuria was detected in 19.1% and hemoglobinuria in 4.5% of the examined subjects. Glomerular filtration rate (Modification of Diet in Renal Disease (MDRD) formula) below 60 mL/min/1.73 m 2 was found in 5.2% of subjects. Kidney ultrasound examination detected reduced length of right and left kidneys in 38 and 24 persons, respectively. Cysts were also a frequent finding, but polycystic kidney, hydronephrosis, and kidney stones were found in about 2% each.

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Section: Discussionmentioning

confidence: 97%

High prevalence of kidney disease in two rural communities in Kosovo and Metohia

Stašević¹,

Gorgieva²,

Vasić³

et al. 2010

Renal Failure

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“…The cross-sectional studies involved inhabitants above 18 years of age and were conducted following procedure described in detail elsewhere. 3,4 The above mentioned criteria proposed by Danilovic were used for diagnosis of BEN prevalence cases. Prevalence of BEN was expressed as a percentage of the total number of eligible inhabitants in each village and as a percentage of the number of persons who responded to the invitation and were examined.…”

Section: Methodsmentioning

confidence: 99%

“…2 Later on, field studies were repeated only in the most affected villages. 3,4 These studies, as well as a recent analysis of age-standardized incidence rates of BEN in the municipality of Lazarevac over 33 years, 5 showed that BEN still exists in the municipality. However, different trends of BEN over time were found, not only in different endemic regions but also between some villages in the same endemic region.…”

Section: Introductionmentioning

confidence: 96%

Trends in Incidence and Prevalence of Balkan Endemic Nephropathy in the Three Most Affected Villages in Serbia Over a 36-Year Period

Janković

Bukvić²,

Marinković

et al. 2013

Renal Failure

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The study was undertaken with the aim to evaluate trends in incidence and prevalence of Balkan endemic nephropathy (BEN) in the villages Šopić, Petka, and Vreoci, Lazarevac municipality, Serbia. Data concerning BEN notifications in the population-based registry of the Special Hospital for Endemic Nephropathy, Lazarevac were used to evaluate BEN incidence rates in the three villages over the period 1973À2008. Population estimates were based on national census data. All age-adjusted incidence rates were standardized to the European standard population and trends were assessed by Poisson regression model and joinpoint analysis. The prevalence of BEN was obtained in cross-sectional studies carried out in the villages Šopić (1971 and 1992), Vreoci (1971and 2002), and Petka (1971 and 2008. The overall agestandardized incidence rates of BEN in the three villages changed over time. The significant 8.6% annual decrease in the first 16 years of the observed period was followed by a slight increase of 4.6% annually in the last two decades. The agestandardized incidence rates changed over time, being the greatest in the years when the field investigations were made. There was an insignificant change in BEN prevalence in Šopić and Vreoci and a significant decrease in prevalence in Petka. During a 36-year period, 367 new cases of BEN were registered in the three endemic villages and the overall agestandardized incidence rate varied over time. As BEN is a slow-progressing and asymptomatic chronic kidney disease, early detection of BEN can only be achieved by field examination.

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“…2,8 Existing literature and prior studies have demonstrated that increased β 2 -microglobulin and reduced kidney length were associated with both BEN patients and their healthy offspring. [9][10][11][12][13][14][15] Moreover, increased C-reactive protein (CRP) and narrow kidney cortex width were related to a parental history of BEN (PHB) before the disease manifestation. A reduced CCr was connected to both BEN patients and offspring, and it was inversely correlated with kidney sizes in BEN patients.…”

Section: Introductionmentioning

confidence: 99%

“…A reduced CCr was connected to both BEN patients and offspring, and it was inversely correlated with kidney sizes in BEN patients. 9,13,15 Even when an affected family has been verified, it is still uncertain how the disease develops in offspring. We hypothesized that kidney length and cortex width, CCr, CRP, or β 2 -microglobulin may be intervening factors between PHB and BEN development.…”

Section: Introductionmentioning

confidence: 99%

The role of a parental history of Balkan endemic nephropathy in the occurrence of BEN: a prospective study

Hanjangsit¹,

Karmaus²,

Dimitrov³

et al. 2012

IJNRD

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Balkan endemic nephropathy (BEN) is a chronic kidney disease that affects persons living in the Balkans. Despite the unique geographical specificity of this disease, its etiology has remained unclear. Even if a positive family history of BEN has been identified, it is still uncertain how the disease develops in offspring. In this paper, we examine clinical mechanisms related to the onset of BEN in individuals who have a parental history of BEN to identify early detection of the disease and formulate interventions. We conducted a 5-year prospective study, using markers in years one and three to predict new cases of BEN in year five. New cases of BEN were defined based on three criteria: parental history of BEN, reduced kidney size, and reduced kidney function. Incident cases were divided into (1) probable, (2) definite, and (3) combined labeled total incidence. We evaluated parental history in relation to BEN and tested the potentially intervening effects of kidney length, kidney cortex width, β 2 -microglobulin, C-reactive protein, and creatinine clearance, using path analyses. The findings of the path analyses suggested that parental history of BEN had both direct and indirect effects. The direct effect was significant for all three modes of parental history (biparental, maternal, and paternal; odds ratios 71.5, 52.3, and 50.1, respectively). The indirect effects of maternal BEN acted via kidney length and creatinine clearance. Biparental BEN was mediated by (1) kidney length and creatinine clearance, and (2) creatinine clearance alone. Paternal BEN had three indirect effects: (1) through kidney length and creatinine clearance, (2) via kidney cortex width and creatinine clearance, and (3) via kidney cortex width only. In conclusion, a family history of BEN led to reduced kidney length and cortex width, and a decline in creatinine clearance, which in turn predicted the onset of BEN.

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Prevalence of Balkan Endemic Nephropathy Has Not Changed Since 1971 in the Kolubara Region in Serbia

Cited by 27 publications

References 25 publications

High prevalence of kidney disease in two rural communities in Kosovo and Metohia

High prevalence of kidney disease in two rural communities in Kosovo and Metohia

Trends in Incidence and Prevalence of Balkan Endemic Nephropathy in the Three Most Affected Villages in Serbia Over a 36-Year Period

The role of a parental history of Balkan endemic nephropathy in the occurrence of BEN: a prospective study

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