Prevalence of Barrett's esophagus in Korea

Kim, Jin Yong; Kim, Young Sun; Jung, Moon Ki; Park, Jong Jae; Kang, Dong Hoon; Kim, Jae Seon; Song, Chi; Lee, Sang Woo; Bak, Young Tae

doi:10.1111/j.1440-1746.2005.03749.x

Cited by 53 publications

(74 citation statements)

References 25 publications

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“…The first multicenter prospective study for LSBE was conducted on 1,553 patients at five referral hospitals in Seoul, and the prevalence of BE was 0.3% [22]. After 2 years, the prevalence of SSBE was assessed prospectively in four referral hospitals of Seoul and the metropolitan areas on 992 patients; CLE was found in 108 patients (10.9%), the overall prevalence of SIM was 3.6%, and only three patients had LSBE [23]. In a single-center study of 70,103 patients given upper endoscopies, 696 (1%) patients had CLE, and BE was present in 151 patients (0.22%) [24].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study

et al. 2009

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Purpose In contrast to the Western population, the prevalence of Barrett's esophagus (BE) is rare in the Korean population. However, the recent increase in prevalence of gastroesophageal reflux disease (GERD) may affect the prevalence of BE. The aim of this study was to survey the prevalence of BE and evaluate its risk factors. Methods Patients between 18 and 75 years of age who visited 11 Korean tertiary referral centers between April and July 2006 for routine upper endoscopic examination were surveyed using a symptom questionnaire. Biopsies were performed on the columnar lined epithelium (CLE) of the distal esophagus, and diagnosis was confirmed with detection of specialized intestinal metaplasia. Results The study comprised 2,048 patients (mean age 51.4 years, 965 males). The frequency of heartburn or acid regurgitation was 8.7% and 13.1%, respectively. Reflux esophagitis was diagnosed in 10.1% of patients (207 patients); however, most patients had mild reflux. CLE was found in 82 patients; however, only one patient had longsegment CLE. The prevalence of BE was 1% (21 patients). The risk factors for BE were age (P = 0.006), presence of heartburn [odds ratio (OR) 4.33, 95% confidence interval (CI) 1.66-11.34, P = 0.007], acid regurgitation (OR 3.37, 95% CI 1.35-8.42, P = 0.01), sliding hernia (OR 6.21, 95% CI 1.78-21.72, P = 0.001), and reflux esophagitis Sci (2010) 55:1932-1939 DOI 10.1007 (OR 10.28, 95% CI 4.31-24.50, P \ 0.0001) on univariate analysis. On multivariate analysis, presence of typical reflux symptoms (P = 0.02) and reflux esophagitis (P \ 0.001) were significant. Conclusions Prevalence of Barrett's esophagus remains low in Koreans; however, risk of developing BE has increased in patients with GERD symptoms and reflux esophagitis.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study

et al. 2009

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“…32 The prevalence of BE was lower in women than in men (Table). 7,19,[40][41][42][43][44][45][46][47][48][49][50][51] A systematic review after analyzing the PubMed database between 1997 and 2011 has shown that the prevalence of BE was lower in women than in men (28 out of 10 337, range 0.03-4.6% vs 70 out of 12 463, range 0.08-8.2%).…”

Section: Prevalence Of Barrett's Esophagusmentioning

confidence: 99%

Sex and Gender Differences in Gastroesophageal Reflux Disease

Kim

2016

J Neurogastroenterol Motil

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125

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It is important to understand sex and gender-related differences in gastroesophageal reflux disease (GERD) because gender-related biologic factors might lead to better prevention and therapy. Non-erosive reflux disease (NERD) affects more women than men. GERD symptoms are more frequent in patients with NERD than in those with reflux esophagitis. However, men suffer pathologic diseases such as reflux esophagitis, Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC) more frequently than women. The prevalence of reflux esophagitis is significantly increased with age in women, especially after their 50s. The mean age of EAC incidence in women is higher than in men, suggesting a role of estrogen in delaying the onset of BE and EAC. In a chronic rat reflux esophagitis model, nitric oxide was found to be an aggravating factor of esophageal injury in a male-predominant way. In addition, the expression of esophageal occludin, a tight junction protein that plays an important role in the esophageal defense mechanism, was up-regulated in women. This explains the male predominance of reflux esophagitis and delayed incidence of BE or EAC in women. Moreover, the symptoms such as heartburn, regurgitation, and extra-esophageal symptoms have been more frequently reported by women than by men, suggesting that sex and gender play a role in symptom perception. Differential sensitivity with augmented symptoms in women might have diagnostic and therapeutic influence. Furthermore, recent studies have suggested that hormone replacement therapy has a protective effect against esophageal cancer. However, an anti-inflammatory role of estrogen remains compelling, which means further study is necessary in this area.

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“…Although total gastrectomy and Roux-en Y procedure is a common procedure in Korea because of high incidence of gastric carcinoma, development of BE in these patients is not reported yet. This may be due to lower prevalence of BE in Korea than Western countries, 16 and low awareness of BE by endoscopists during follow up. Therefore, careful follow-up and endoscopic examination is required, since recurrent carcinoma after total gastrectomy has a chance to be adenocarcinoma associated with BE.…”

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confidence: 88%

Development of Barrett's Esophagus Soon after Total Gastrectomy

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Kim²,

Kim³

et al. 2008

Gut Liver

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The role of duodenal reflux and the time required for the development of Barrett's esophagus has remained controversial. We report a case of Barrett's esophagus that developed 6 months after total gastrectomy. A 76-year-old man diagnosed with gastric adenocarcinoma underwent a total gastrectomy and a Rouxen-Y esophagojejunostomy. The gastroesophageal junction in the resected specimen was both grossly and microscopically normal at the time of the operation. A routine follow-up endoscopic examination performed 6 months later revealed a tongue-like projection of redcolored columnar tissue. No reflux symptoms (heartburn or acid regurgitation) had been present during the intervening 6 months. A biopsy specimen from the esophagus showed intestinal-type metaplasia of the columnar epithelium. This case supports the development of Barrett's esophagus solely from duodenal reflux and after a relatively short time in this clinical setting. (Gut and Liver 2008;2:51-53)

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Prevalence of Barrett's esophagus in Korea

Abstract: Although the prevalence of BE in Korea appears to be lower than the reported rates from Western countries, it may not be as low as was previously thought.

Cited by 53 publications

References 25 publications

Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study

Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study

Sex and Gender Differences in Gastroesophageal Reflux Disease

Development of Barrett's Esophagus Soon after Total Gastrectomy

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