Prevalence of behaviour disorders in low birthweight infants.

Pharoah, P. O. D.; Stevenson, C. J.; Cooke, Richard; Stevenson, Richard

doi:10.1136/adc.70.4.271

Cited by 134 publications

(90 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to autism, low birth weight has been associated with a variety of psychiatric, cognitive, and behavioral problems. [84][85][86][87][88][89][90][91][92][93] Season or month of birth was significantly related to the risk of autism in 6 of 12 studies. Although the seasonal trends varied across studies, March 10,23,60,64 and August 10 were both suggested as birth months associated with an elevated risk of autism.…”

Section: Resultsmentioning

confidence: 99%

Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-Analysis

2011

PEDIATRICS

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT:Autism etiology is unknown, although perinatal and neonatal exposures have been the focus of epidemiologic research for more than 40 years. Although studies show that obstetrical and neonatal complications may increase autism risk, the specific complications and magnitude of effect have been inconsistent. WHAT THIS STUDY ADDS: OBJECTIVE:To provide the first review and meta-analysis of the association between perinatal and neonatal factors and autism risk. METHODS:PubMed, Embase, and PsycInfo databases were searched for studies that examined the association between perinatal and neonatal factors and autism through March 2007. Forty studies were eligible for the meta-analysis. For each exposure, a summary effect estimate was calculated using a random-effects model. Heterogeneity in effect estimates across studies was examined, and, if found, a metaregression was conducted to identify measured methodological factors that could explain between-study variability. RESULTS:Over 60 perinatal and neonatal factors were examined. Factors associated with autism risk in the meta-analysis were abnormal presentation, umbilical-cord complications, fetal distress, birth injury or trauma, multiple birth, maternal hemorrhage, summer birth, low birth weight, small for gestational age, congenital malformation, low 5-minute Apgar score, feeding difficulties, meconium aspiration, neonatal anemia, ABO or Rh incompatibility, and hyperbilirubinemia. Factors not associated with autism risk included anesthesia, assisted vaginal delivery, postterm birth, high birth weight, and head circumference. CONCLUSIONS:There is insufficient evidence to implicate any 1 perinatal or neonatal factor in autism etiology, although there is some evidence to suggest that exposure to a broad class of conditions reflecting general compromises to perinatal and neonatal health may increase the risk. Methodological variations were likely sources of heterogeneity of risk factor effects across studies. Pediatrics 2011;128: 344-355

show abstract

Section: Resultsmentioning

confidence: 99%

Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-Analysis

2011

PEDIATRICS

View full text Add to dashboard Cite

show abstract

“…Conseqüentemente, tem aumentado o interesse sobre a investigação da qualidade de vida e a morbidade desses recém-nascidos 1,2 .…”

Section: Introductionunclassified

Desempenho motor em recém-nascidos pré-termo de alto risco

Nicolau

Costa

Hazime

et al. 2011

J. Hum. Growth Dev.

View full text Add to dashboard Cite

Nicolau CM. et al. Desempenho motor em recém-nascidos pré-termo de alto risco. Rev Bras Cresc e Desenv Hum 2011; 21(2): 327-334. RESUMOObjetivo: avaliar o desempenho motor em recém-nascidos pré-termo (RNPT) com risco para o desenvolvimento motor. Método: estudo prospectivo entre junho 2007 e dezembro 2008 com RN estáveis, respiração espontânea em ar ambiente e idade corrigida até 120 dias de vida. O estudo consistiu na avaliação do desempenho motor através do Test of Infant Motor Performance (TIMP), sendo aplicado por fisioterapeuta treinado, na alta hospitalar. A análise dos resultados foi realizada através de medidas descritivas e medidas de sensibilidade, especificidade e valores preditivos positivo e negativo. Resultados: Foram estudados 69 RNs com idade gestacional (IG) média 32,61 ± 2,69 semanas e peso médio 1207,00 ± 380,14 gramas, com predomínio do sexo masculino (62%) e dos adequados para a idade gestacional (66,6%). Da população estudada 56 RN apresentaram pontuação na média, 7 apresentaram pontuação abaixo da média e 6 apresentaram escores muito abaixo da média. Os RN com pontuação dentro da média apresentaram IG média 34,44 ± 0,59 sem, peso médio de nascimento 1355,50 ± 294,26 gramas e permaneceram em média 11,22 ± 7,07 dias em oxigênio inalatório. Os RN que obtiveram desempenho abaixo da média apresentaram IG média 32,00 ± 2,59 sem, peso médio de nascimento 1180,00 ± 334,16 gramas e permaneceram 8,20 ± 4,24 dias sob ventilação mecânica (VM); os RN com pontuação muito abaixo da média apresentaram IG média 28,76 ± 2,54 sem, peso de nascimento 830,00 ± 332,06 g e permaneceram em média 42,50 ± 18,93 dias em VM. Verificou-se 54,5% sensibilidade, 71,4% especificidade e valores preditivos positivo e negativo de 75% e 100%. Conclusão: Os RNPT que apresentaram pior desempenho motor foram os que permaneceram em suporte ventilatório prolongado.Palavras-chave: desenvolvimento motor; recém-nascido; prematuro. Rev Bras Crescimento Desenvolvimento Hum. 2011; 21(2): 327-334 PESQUISA ORIGINAL ORIGINAL RESEARCH

show abstract

“…2 Behavioral problems in these children mainly manifest in an increased risk for attention-deficit/hyperactivity disorder 3 and internalizing behavioral problems such as withdrawn behavior, 6 although some studies have also found oppositional behavior. 8,9 A large body of evidence has shown that academic underachievement and behavioral problems arise from a deficit in EF, [10][11][12][13] a set of neurocognitive functions such as inhibitory control, working memory, cognitive flexibility, and planning. 14 EF, therefore, has attracted considerable interest, and in very preterm and/or VLBW children executive dysfunction has been reported, suggested to arise from disruptions of cortical and subcortical circuits connecting frontal, striatal, and thalamic regions.…”

mentioning

confidence: 99%

Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children

et al. 2009

View full text Add to dashboard Cite

Birth Weight Children Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Lowhttp://www.pediatrics.org/cgi/content/full/124/2/717 located on the World Wide Web at:The online version of this article, along with updated information and services, is Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children abstract OBJECTIVE: Sequelae of academic underachievement, behavioral problems, and poor executive function (EF) have been extensively reported for very preterm (Յ33 weeks' gestation) and/or very low birth weight (VLBW) (Յ1500 g) children. Great variability in the published results, however, hinders the field in studying underlying dysfunctions and developing intervention strategies. We conducted a quantitative meta-analysis of studies published between 1998 and 2008 on academic achievement, behavioral functioning, and EF with the aim of providing aggregated measures of effect size for these outcome domains.METHODS: Suitable for inclusion were 14 studies on academic achievement, 9 studies on behavioral problems, and 12 studies on EF, which compared a total of 4125 very preterm and/or VLBW children with 3197 term-born controls. Combined effect sizes for the 3 outcome domains were calculated in terms of Cohen's d. Q-test statistics were performed to test homogeneity among the obtained effect sizes. Pearson's correlation coefficients were calculated to examine the impact of mean birth weight and mean gestational age, as well as the influence of mean age at assessment on the effect sizes for academic achievement, behavioral problems, and EF. RESULTS:Combined effect sizes show that very preterm and/or VLBW children score 0.60 SD lower on mathematics tests, 0.48 SD on reading tests, and 0.76 SD on spelling tests than term-born peers. Of all behavioral problems stacked, attention problems were most pronounced in very preterm and/or VLBW children, with teacher and parent ratings being 0.43 to 0.59 SD higher than for controls, respectively. Combined effect sizes for parent and teacher ratings of internalizing behavior problems were small (Ͻ0.28) and for externalizing behavior problems negligible (Ͻ0.09) and not significant. Combined effect sizes for EF revealed a decrement of 0.57 SD for verbal fluency, 0.36 SD for working memory, and 0.49 SD for cognitive flexibility in comparison to controls. Mean age at assessment was not correlated with the strength of the effect sizes. Mathematics and reading performance, parent ratings of internalizing problems, teacher ratings of externalizing behavior, and attention problems, showed strong and positive correlations with mean birth weight and mean gestational age (all r values Ͼ 0.51). CONCLUSIONS:Very preterm and/or VLBW children have moderate-toseveredeficitsinacademicachievement,attentionproblems,andinternalizing behavioral problems and poor EF, which are adverse outcomes that were strongly correlated to their immaturity at birth. During transition to young adulthood these children continue to lag behind term-born peers.

show abstract

Prevalence of behaviour disorders in low birthweight infants.

Abstract: Objective -To determine the prevalence of behaviour disorders in low birthweight infants. Design

Cited by 134 publications

References 16 publications

Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-Analysis

Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-Analysis

Desempenho motor em recém-nascidos pré-termo de alto risco

Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children

Contact Info

Product

Resources

About