Prevalence of Beta-Thalassemia Trait and Abnormal Hemoglobins in the Province of Adıyaman, Turkey

Genç, Ahmet; Korkmaz, Deniz Taştemir; Kucuk, Meral Urhan; Rencuzogullari, Eyup; Atakur, Selman; Bayram, Süleyman; Onderci, Muhittin; Koç, Tuba; Aslan, Sinan; Mutalip, Abdullah; Faruk, Muslum; Sevgiler, Yusuf; Tunçdemir, Aygül

doi:10.3109/08880018.2012.713085

Cited by 8 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This ratio is as high as 13% in some regions including Meditteranean, Agean and Trachian regions. 7 Several ethnic groups living in this area may have played a role in developing thalassemic cases due to marriage between close relatives. 2 Nutritional deficiencies like iron, and vitamin B12 are also frequent in people living in these areas.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Iron, Folic Acid and Vitamin B12 Deficiency in Patients with Thalassemia Minor

Asma¹,

Gereklioğlu²,

Erdoğan³

et al. 2013

TJFMPC

View full text Add to dashboard Cite

ÖZET Talasemi Minor'da Demir, Folik Asit ve B12 Eksikliği PrevalansıTalasemi taşıyıcılığına bağlı anemi bölgemizde sık karşılaşılan hematolojik bir problemdir ve demir eksikliği anemisi ile karışabilmektedir. Her ikisinin birlikte olduğu olgularda anemi daha da derinleşmesine rağmen konu ile ilgili kaynaklarda bilgiler yeteri kadar açık değildir. Bu çalışma, beta talasemi taşıyıcılığı tanısı alan hastaların besinsel durumunu (demir, folik asit ve vitamin B12) değerlendirmesi amacıyla yapılmıştır. Çalışmaya beta talasemi taşıyıcılığı tanısı almış alan 47'si erkek toplam 183 hasta alındı. Kadın hastaların %17.5 sinde ve erkeklerin % 1.6'sinde demir eksikliği olduğu tespit edildi. Vitamin B12 ve folik asit düşüklüğü sırasıyla %28.7, %10.3 olarak saptandı. Çalışmamız sonucunda takip edilen talasemi taşıyıcılığında eşlik eden demir eksikliği ve diğer besinsel anemilerin (vitamin b12 ve folik asit eksikliği) varlığının araştırılmasının yararlı olabileceği düşünülmektedir. ABSTRACT Prevalence of Iron, Folic Acid and Vitamin B12 Deficiency in Patients with Thalassemia MinorThalassemia trait -related anemia is a common hematologic problem in Mediterranean region. This type of anemia may be frequently confused with iron deficiency anemia. Anemia becomes more severe in case of coexistence of both anemia types and literature knowledge is sparse on that issue. This study was carried out with the aim of investigation of iron, folic acid and vitamin B12 levels in patients who were diagnosed with beta thalassemia trait. A total of 183 patients (47 male, 136 female) who were diagnosed with beta thalassemia minor were enrolled in the study. Iron deficiency was detected in 17.5% of women and in 1.6% of men. Decreased vitamin B12 and folic acid values were detected as 28.7% and 10.3%, respectively. It was concluded that serum iron, folic acid and vitamin B12 levels should also be measured in assessment of talassemia trait patients due to its high prevalence in study region. of iron, folic acid and vitamin B12 deficiency in patients with thalassemia minor. TJFMPC 2013;7(4):83-86.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of Iron, Folic Acid and Vitamin B12 Deficiency in Patients with Thalassemia Minor

Asma¹,

Gereklioğlu²,

Erdoğan³

et al. 2013

TJFMPC

View full text Add to dashboard Cite

show abstract

“…The corresponding figures in the southeastern Anatolia cities were 1.30 and 1.87% in Adiyaman and Gaziantep, respectively (Table 2) (8,11,(14)(15)(16). The highest frequency rate of b-thal incidence among the Southeastern Anatolian provinces (compared with Adiyaman and Gaziantep) was found in Sanliurfa.…”

Section: Discussionmentioning

confidence: 83%

Prevalence of β-Thalassemia Trait and Abnormal Hemoglobins in Sanliurfa Province in Southeast Turkey

et al. 2014

Self Cite

View full text Add to dashboard Cite

Thalassemia is one of the most common hereditary disorders in Turkey, especially in the Mediterranean region of the country. The purpose of this study was to determine the frequency of the β-thalassemia (β-thal) trait and abnormal hemoglobins (Hbs) in couples who applied for premarital screening in Sanliurfa Province, in the southeastern region of Turkey, a province with the first reported incidence of β-thal and abnormal Hbs. In the present study, in order to detect the prevalence of the β-thal trait and abnormal Hbs in Sanliurfa Province, Turkey, a total of 37,962 couples who applied for premarital screening were analyzed. From January 2011 through March 2014, red blood cell (RBC) counts and Hb fractionation were carried out by a cell counter and high performance liquid chromatography (HPLC), respectively. The prevalence of β-thal with high Hb A2 (>3.5%) values was found at rates of 2.44% (n = 1853) in Sanliurfa Province. Additionally, the abnormal Hb rate was 1.57% (1193/75,924), and Hb S (HBB: c.20T > A), Hb C (HBB: c.19G > A) and Hb D-Punjab (HBB: c.364G > C) were reported as 0.50, 0.38 and 0.69, respectively. This study is the first to establish the frequency of β-thal and abnormal Hbs in Sanliurfa Province, which has the highest birth frequency. We report that the frequency of the β-thal trait is at a high-risk level compared to other cities in Turkey. Due to the high risk of β-thal in Sanliurfa Province, a premarital screening program would be of great value in informing parents about offspring with β-thal.

show abstract

“…During the last five years, several variants, each belonging to one family, confirmed with DNA sequencing were reported ( Table 1 ) [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Two further new variants (Hb İzmir and Hb Edirne) was reported in Turkish population for the first time [ 18 , 21 ].…”

Section: To the Editormentioning

confidence: 99%

An Updated Review of Abnormal Hemoglobins in the Turkish Population

Akar¹

2014

Tjh

View full text Add to dashboard Cite

Prevalence of Beta-Thalassemia Trait and Abnormal Hemoglobins in the Province of Adıyaman, Turkey

Cited by 8 publications

References 9 publications

Prevalence of Iron, Folic Acid and Vitamin B12 Deficiency in Patients with Thalassemia Minor

Prevalence of Iron, Folic Acid and Vitamin B12 Deficiency in Patients with Thalassemia Minor

Prevalence of β-Thalassemia Trait and Abnormal Hemoglobins in Sanliurfa Province in Southeast Turkey

An Updated Review of Abnormal Hemoglobins in the Turkish Population

Contact Info

Product

Resources

About