Prevalence of Bilirubin Encephalopathy in Calabar, South-South, Nigeria (A 5-Year Review)

Ochigbo, S O; Venn, Ifeoma; Akaba, Kingsley

doi:10.6000/1929-4247.2015.04.04.7

Cited by 8 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present study observed a prevalence rate of 5.3% of conjunctivitis among hospitalized neonates. This is higher than 1.1% and 4.1% reported by Ochigbo et al from Nigeria and Goel et al from India respectively [3,18] , but lower than the 7.2%, 8.0% and 8.2% observed by other researchers from India, Togo and the United Kingdom respectively. [10,14,19] However, it has been pointed out that the incidence of neonatal conjunctivitis tends to vary widely from region to region.…”

Section: Discussioncontrasting

confidence: 55%

See 1 more Smart Citation

Conjunctival bacterial infection among hospitalized neonates

Ogunfowora¹,

Ajewole²,

Ajibode³

2020

Ann Health Res

View full text Add to dashboard Cite

Background: Conjunctivitis is a common infection among neonates and it is a known cause of preventable childhood blindness. There is geographical variation in the distribution of aetiological agents. Objective: To assess the prevalence of conjunctivitis among hospitalized neonates receiving care in a tertiary health care centre in South-west Nigeria, and describe its clinical and bacteriological correlates. Methods: The hospital records of neonates diagnosed with conjunctivitis at the Olabisi Onabanjo University Teaching Hospital, Sagamu between January 2015 and December 2019 were reviewed. Their bio-data, perinatal history, laboratory results and treatment received were extracted for analysis. Results: One hundred and twenty-two neonates had conjunctivitis out of a total number of 2,286 admissions, giving a prevalence rate of 5.3%. Male infants had almost double the risk of developing the disease compared to female infants (OR = 1.6; 95% CI: 1.09-2.35). Eighty-six (70.5%) babies were term, while 21 (17.2%) and 15 (12.3%) were preterm and small-for-gestational-age respectively. Most cases of neonatal conjunctivitis (82.0%) occurred in the first week of life while the mean ±SD age of onset was 5.3±4.5 days. Staphylococcus aureus and Klebsiella species were the commonest bacterial isolates affecting 57.1% and 23.0% neonates respectively. Moderately-high rates of resistance to erythromycin and gentamicin were observed among the bacterial isolates. Conclusion: Neonatal conjunctivitis is commonly due to Staphylococcus aureus and Klebsiella species in this setting. It is commoner among male infants. Most cases run a mild course with good response to topical antimicrobial therapy.

show abstract

Section: Discussioncontrasting

confidence: 55%

“…However, incidence rates of 1.1%among hospitalized neonates and 4.7/1000 live births have been reported. [3,4] Depending on the severity, the infection is potentially hazardous as it can lead to varying degrees of ocular and systemic…”

Section: Introductionmentioning

confidence: 99%

Conjunctival bacterial infection among hospitalized neonates

Ogunfowora¹,

Ajewole²,

Ajibode³

2020

Ann Health Res

View full text Add to dashboard Cite

show abstract

“…In this study, 10 babies (0.6%) developed acute bilirubin encephalopathy. In 1 study done in Calabar, South Nigeria, the prevalence of ABE was estimated at 0.7%, 28 and another study in China showed a prevalence of 0.5% ABE in preterm neonates. 29 Among the preterm babies who developed ABE, for the majority, the bilirubin level was above 20.1 mg/dL.…”

Section: Discussionmentioning

confidence: 97%

Hyperbilirubinemia in Preterm Infants Admitted to Neonatal Intensive Care Units in Ethiopia

Aynalem

Abayneh

Metaferia

et al. 2020

Global Pediatric Health

View full text Add to dashboard Cite

Background. Hyperbilirubinemia is prevalent and protracted in preterm infants. This study assessed the pattern of hyperbilirubinemia in preterm infants in Ethiopia. Methods. This study was part of multi-centered prospective, cross-sectional, observational study that determined causes of death among preterm infants. Jaundice was first identified based on clinical visual assessment. Venous blood was then sent for total and direct serum bilirubin level measurements. For this study, a total serum bilirubin level ≥5 mg/dL was taken as the cutoff point to diagnose hyperbilirubinemia. Based on the bilirubin level and clinical findings, the final diagnoses of hyperbilirubinemia and associated complications were made by the physician. Result. A total of 4919 preterm infants were enrolled into the overall study, and 3852 were admitted to one of the study’s newborn intensive care units. Of these, 1779 (46.2%) infants were diagnosed with hyperbilirubinemia. Ten of these (0.6%) developed acute bilirubin encephalopathy. The prevalence of hyperbilirubinemia was 66.7% among the infants who were less than 28 weeks of gestation who survived. Rh incompatibility ( P = .002), ABO incompatibility ( P = .0001), and sepsis ( P = .0001) were significantly associated with hyperbilirubinemia. Perinatal asphyxia ( P-value = 0.0001) was negatively associated with hyperbilirubinemia. Conclusion. The prevalence of hyperbilirubinemia in preterm babies admitted to neonatal care units in Ethiopia was high. The major risk factors associated with hyperbilirubinemia in preterm babies in this study were found to be ABO incompatibility, sepsis, and Rh isoimmunization.

show abstract

“…Pakistan and Nigeria documenting rates of 27.6% and 19.6%, respectively [6]. Contributing to these elevated bilirubin levels are factors such as infection, ABO incompatibility, and glucose-6-phosphate dehydrogenase (G6PD) de ciency [7].…”

Section: Studies Across Various Regions Have Reported Varying Inciden...mentioning

confidence: 99%

Retrospective Analysis of Neonatal Hyperbilirubinemia at Hiwot Fana Specialized Hospital, Ethiopia: Prevalence, Associated Factors, and Treatment Outcomes

Abdirahman¹,

Libe²,

Gebru³

2024

Preprint

View full text Add to dashboard Cite

Background Neonatal hyperbilirubinemia, also known as neonatal jaundice, is a condition characterized by yellowish discoloration of the skin and eyes caused by bilirubin buildup in the body. Understanding its prevalence, associated factors, and outcomes is crucial for effective management. Objectives This study aimed to assess the prevalence, associated factors, and treatment outcomes of neonatal hyperbilirubinemia at Hiwot Fana Specialized Hospital, Eastern Ethiopia. Methodology: A hospital-based cross-sectional study was conducted from December 1, 2020, to December 30, 2020, involving 328 neonates admitted to the Neonatal Intensive Care Unit. Data were collected using a checklist and analyzed using SPSS version 22. Result Neonatal hyperbilirubinemia prevalence was 44.2%, with 1.4% progressing to bilirubin encephalopathy. Sepsis (44.8%) and prematurity (22%) were major contributing factors. Most neonates were treated with phototherapy alone (82.3%), and 93.8% showed improvement. Conclusion The study underscores the importance of early detection and management of neonatal hyperbilirubinemia to prevent adverse outcomes. Recommendations include integrating jaundice prevention into antenatal care and ensuring timely bilirubin level checks in neonates.

show abstract

Prevalence of Bilirubin Encephalopathy in Calabar, South-South, Nigeria (A 5-Year Review)

Cited by 8 publications

References 13 publications

Conjunctival bacterial infection among hospitalized neonates

Conjunctival bacterial infection among hospitalized neonates

Hyperbilirubinemia in Preterm Infants Admitted to Neonatal Intensive Care Units in Ethiopia

Retrospective Analysis of Neonatal Hyperbilirubinemia at Hiwot Fana Specialized Hospital, Ethiopia: Prevalence, Associated Factors, and Treatment Outcomes

Contact Info

Product

Resources

About