Prevalence of Biofilm-forming Bacteria in Chronic Rhinosinusitis

Prince, Anthony; Steiger, Jacob D.; Khalid, Ayesha N.; Dogrhamji, Laurel; Reger, Christine; Claire, Steven Eau; Chiu, Alexander G.; Kennedy, David W.; Palmer, James N.; Cohen, Noam A.

doi:10.2500/ajr.2008.22.3180

Cited by 154 publications

(140 citation statements)

References 27 publications

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“…The prevalence of biofilms in CRS patients has been reported to range from 28.6 to 60 % [19,20]. Cryer first detected biofilms in CRS patients by SEM [21].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Jung

Eog

Kang

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Recent studies have indicated that biofilms are involved in the pathogenesis of recurrent and recalcitrant chronic rhinosinusitis (CRS). The present study was performed to evaluate the presence of biofilms and to evaluate the relationships between the presence of biofilms and clinical features of CRS. A total of 33 patients were included in this study. Maxillary sinus mucosa from 26 CRS patients and the ethmoid mucosa from 7 patients undergoing septoplasty were collected. Biofilms were evaluated by scanning electron microscopy. Preoperative symptom scores, preoperative and intraoperative nasoendoscopic findings, and postoperative healing period were compared between the groups. Biofilms were detected in 14 (42.4 %) of the 33 patients. Biofilms were present in 13 (50 %) of the 26 patients in the CRS group, but in only one (14.3 %) of the seven patients in the control group. There were no significant differences in preoperative symptom scores or preoperative nasal Lund-Kennedy endoscopic scores between the groups. However, the average LundMackay and intraoperative sinus Lund-Kennedy endoscopic scores were significantly higher in biofilm-positive than biofilm-negative patients (P \ 0.05). In the follow-up period, the healing time was significantly longer in biofilmpositive than biofilm-negative patients (P \ 0.05). This study suggested that the presence of bacterial biofilms may contribute to the pathogenesis of CRS and the clinical characteristics of CRS patients after endoscopic sinus surgery.

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“…The prevalence of biofilms in CRS patients has been reported to range from 28.6 to 60 % [19,20]. Cryer first detected biofilms in CRS patients by SEM [21].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Jung

Eog

Kang

et al. 2014

Indian J Otolaryngol Head Neck Surg

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“…These bacteria primarily exist within biofilms, which are present in 29-72% of CS patients. [38][39][40][41][42][43][44] In eosinophilic disease, these bacteria commonly include Staphylococcus spp. 8,45 These bacteria can drive the recurrent acute infections that plague CS patients, when they transform into their planktonic state and emerge from the biofilm.…”

Section: Sensitization To Colonizing Pathogens Bacteriamentioning

confidence: 99%

Chronic sinusitis pathophysiology: The role of allergy

Kennedy

Borish

2013

Am J Rhinol�Allergy

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“…The expression of these two genes has been observed to be significantly higher in patients with chronic rhinosinusitis (CRS) compared to those without an infection. Another study demonstrated the mRNA and protein expression of TLRs 2, 3, and 4 in the nasal mucosa of patients with intermittent allergic rhinitis [12]- [14]. Furthermore, an increase in the protein expression of all three of these receptors was observed in the nasal mucosa of individuals following an allergen challenge [15].…”

Section: Discussionmentioning

confidence: 99%

Toll-Like Receptor Gene Expression in Nasal Polyp

Yurttaş¹,

Apuhan²,

Şimşek³

et al. 2016

IJOHNS

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Objective: To investigate the expression of Toll-like receptors (TLRs) and the correlation between TLR expression and mucosal changes in chronic sinusitis-related nasal polyposis. Methods: Patients with nasal polyps were enrolled in this study as the study group. The control group consisted of individuals undergoing surgery due to nasal obstruction caused by concha hypertrophy who were not diagnosed with chronic sinusitis-related nasal polyposis (NP). There were 30 patients in the study group (individuals with NP) and 20 patients in the control group. Sterile tissue samples were taken from the patients and were kept at −80˚C. A piece of tissue sample was put into the eppendorf tube. Expression of TLR2 and TLR4 gene was investigated in the tissue samples. The samples were taken after the surgery; they were carried into the liquid nitrogen and were kept at −80˚C before study. Results: TLR2 and TLR4 expression was measured in both groups and then analyzed using Student's t-test. In the experimental group, the level of TLR2 expression was significantly higher than in the control group (P < 0.001); however, TLR4 expression was not significantly different between the two groups (P = 0.656). Conclusion: TLRs are thought to play a role in the etiopathogenesis of NP. In addition, the authors consider that a possible treatment for NP could be a TLR-specific treatment. Thus, in the future it will be essential to determine the extent to which TLRs function in NP formation and to apply this knowledge to design a specific therapeutic regimen for the enhanced treatment of NP.

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Prevalence of Biofilm-forming Bacteria in Chronic Rhinosinusitis

Abstract: We show a high percentage of CRS patients (28.6%) whose sinonasal mucopurulence has biofilm-forming capacity. Postsurgical patients had a high prevalence of biofilm-forming bacteria, a possible reflection of the severe nature of their disease. Additional studies are warranted.

Cited by 154 publications

References 27 publications

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Chronic sinusitis pathophysiology: The role of allergy

Toll-Like Receptor Gene Expression in Nasal Polyp

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