Prevalence of BK polyomavirus infection and association with renal dysfunction in pediatric heart transplant recipients

Ducharme‐Smith, Allison; Katz, Ben Z.; Bobrowski, Amy E.; Backer, Carl L.; Rychlik, Karen; Pahl, Elfriede

doi:10.1016/j.healun.2014.09.043

Cited by 11 publications

(15 citation statements)

References 25 publications

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“…BKVN is a well‐known complication of kidney transplantations and can lead to renal allograft failure in this population . While initially thought to be uncommon in patients who have not had a kidney transplant, mounting evidence shows that BKV infection affects the native kidneys of other solid organ transplant recipients as well, in particular heart transplant recipients . Our recent retrospective study found that BKV infection affected up to 34% of pediatric heart transplant recipients, and the rate of progression to BKVN was 1% .…”

Section: Introductionmentioning

confidence: 84%

“…While initially thought to be uncommon in patients who have not had a kidney transplant, mounting evidence shows that BKV infection affects the native kidneys of other solid organ transplant recipients as well, in particular heart transplant recipients . Our recent retrospective study found that BKV infection affected up to 34% of pediatric heart transplant recipients, and the rate of progression to BKVN was 1% . However, the incidence of BKV infection and its association with kidney dysfunction in pediatric heart transplant recipients remains uncertain.…”

Section: Introductionmentioning

confidence: 89%

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BK polyomavirus infection in pediatric heart transplant recipients: a prospective study

Ducharme‐Smith

Katz

Bobrowski

et al. 2016

Pediatric Transplantation

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BKV infection and nephropathy complicate pediatric HTx, but the incidence and time course of the disease are unknown. We assessed the incidence of BKV infection and its association with kidney dysfunction in pediatric HTx recipients. A single center prospective study compared pediatric (<18 years) HTx recipients, with and without BKV infection, who received an allograft between September 2013 and December 2014. Screening of urine for BKV was performed prior to transplant, and at week 1, and at months 3, 6, 9, 12, and 15 months post-transplantation. Serum for BKV DNA was assayed if BK viruria was present. Statistics included Fisher's exact test and Student's t test. Twelve patients were enrolled. Two patients were removed per parent request. Two (20%) had BK viruria and one (10%) had BK viremia. No patients developed BKVN. BK viruria was present within 2 months following transplantation. There were no identifiable risk factors for BKV infection and no statistically significant difference in renal function between the groups; however, there was a trend toward worsening renal function in those with BKV infection. BKV infection can occur early following heart transplantation. Screening for BK viruria should be considered in HTx recipients.

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Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 89%

BK polyomavirus infection in pediatric heart transplant recipients: a prospective study

Ducharme‐Smith

Katz

Bobrowski

et al. 2016

Pediatric Transplantation

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“…Особенно тяжелые проблемы ВК вирусы вызывают у пациентов на фоне лекарственного подавления иммунитета, когда происходит реактивация вирус ной инфекции с виремией и вирурией и развитием иногда фатальных осложнений. Особую актуаль ность представляет своевременная лабораторная диагностика ПВИ, направленная на оперативное выявление возбудителя и определение индивиду альной количественной оценки вирусной нагрузки с целью выработки адекватных подходов к лечению [12][13][14].…”

Section: Discussionunclassified

“…развитие криза отторжения, лимфопролифератив ных заболеваний у пациентов с трансплантирован ной почкой [8][9][10][11][12][13][14][15]. H. Shimohata и соавт.…”

Section: оценка вклада герпесвирусной инфекции в развитие и прогрессиunclassified

Оцінка Вкладу Герпесвірусної Інфекції В Розвиток І Прогресування Хронічних Гломерулярних Хвороб У Дітей

Kazyra¹,

Rubanik²,

Sukala³

et al. 2021

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Êë³í³÷íà ïåä³àòð³ÿ / Clinical Pediatrics ® Введение Этиология хронических болезней клубочково го аппарата почки на сегодняшний день до конца не известна. Описано участие ряда факторов, в том числе вирусных инфекций [1-5]. Внимание к роли вирусов гепатита В и С в развитии гломерулонеф рита знаменовало начало изучения вирусассоци ированных нефропатий [2]. По данным литературы прослежена связь между инфекцией, вызванной вирусами семейства герпесвирусов (вирус простого герпеса (ВПГ), Эпштейна-Барр (ВЭБ), цитоме галовирус (ЦМВ)) и развитием как самого заболе вания, так и провокацией обострений [4-7]. Среди приведенных-нефротический синдром, систем ные заболевания соединительной ткани (системная красная волчанка (СКВ)), ревматоидный артрит, системные васкулиты (IgAваскулит Шенлейна-Геноха (ШГ), гранулематоз Вегенера и др.), а также

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“…Ducharme-Smith et al[ 95 ] found BK viruria in approximately one third and BK viremia in only 7% of pediatric heart transplant recipients. One of the viremic patients developed BKN.…”

Section: Urinary Manifestations Of Bkv Infection In Patients With Bonmentioning

confidence: 99%

BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

Vigil

Konstantinov

Barry

et al. 2016

WJT

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Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy (BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research.

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Prevalence of BK polyomavirus infection and association with renal dysfunction in pediatric heart transplant recipients

Cited by 11 publications

References 25 publications

BK polyomavirus infection in pediatric heart transplant recipients: a prospective study

BK polyomavirus infection in pediatric heart transplant recipients: a prospective study

Оцінка Вкладу Герпесвірусної Інфекції В Розвиток І Прогресування Хронічних Гломерулярних Хвороб У Дітей

BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

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