Prevalence of Bordetella pertussis and Bordetella parapertussis infections in Tunisian hospitalized infants: results of a 4-year prospective study

Zouari, Asma; Smaoui, H.; Brun, Delphine; Njamkepo, Elisabeth; Sghaier, Soufien; Zouari, Emna; Félix, Renaud; Menif, Khaled; Jaballah, N. Ben; Guiso, Nicole; Kechrid, A.

doi:10.1016/j.diagmicrobio.2012.01.002

Cited by 44 publications

(40 citation statements)

References 73 publications

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“…Our findings are in line with a previous study conducted between 2003 and 2004 on patients living in Algiers [23] and with reports from other countries of a resurgence of pertussis despite high vaccination coverage [22][23][24][25][26][27][28][29][30]. Several explanations have been suggested, including the occurrence of pertussis outbreaks, or the two-to five-year cycles of increasing and decreasing incidence.…”

Section: Incidence Of Pertussis Infectionsupporting

confidence: 82%

“…However, a retrospective study of 11,319 PCR assays obtained in 1992-2003 using an IS481 target in Finnish and Dutch patients with suspected pertussis did not detect B. holmesii despite finding 1,856 PCR-positive isolates [21]. The results of a similar four-year prospective study using an IS481 target and conducted from 2007 to 2011 in 599 Tunisian infants did not detect B. holmesii in a total of 126 confirmed cases [22]. Five patients with negative serology were found positive for IS481 by real-time PCR.…”

Section: Laboratory Findingssupporting

confidence: 49%

“…A large majority (89%) were <6 months of age; 61% of those patients were <3 months of age and were thus too young to be fully vaccinated [22,23,29,36]. These findings lead us to question the homogeneity of vaccine coverage rate in our country.…”

Section: Pertussis Confirmed Case Patientsmentioning

confidence: 71%

“…In this study, mothers were most frequent pertussis-confirmed contact of confirmed pertussis patients. They were thus the most likely source for transmitting the infection [22,46,47]. However, it should be noted that investigation of close contacts was systematic in mothers even if they were not symptomatic.…”

Section: Pertussis-confirmed Case Contactsmentioning

confidence: 99%

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Pertussis in north-central and northwestern regions of Algeria

Benamrouche

Maamar

Lazri

et al. 2016

J Infect Dev Ctries

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Introduction: Pertussis outbreaks continue to occur in many countries despite high vaccination coverage. Under-diagnosed cases in adolescents and adults may result in increased transmission to infants, who are at risk of severe pertussis. Additional measures to protect both groups should be considered. Methodology: Nasopharyngeal samples and sera were collected from patients and household contacts with clinically suspected pertussis. Diagnoses were confirmed by culture, real-time polymerase chain reaction (PCR), and serology. Bordetella pertussis isolates were characterized by antimicrobial sensitivity and fimbrial serotyping. Results: Of 392 participants, 134/248 patients (54%) and 66/144 contacts (45.8%) had confirmed pertussis infections. B. parapertussis was not detected. All B. pertussis isolates were sensitive to the antibiotics tested, and all expressed the Fim3, not the Fim2, fimbrial serotype. Most patients (81.2%) were <6 months (51.8% of whom were <3 months) of age; 77.6% were unvaccinated, and most positive contacts were mothers 20-40 years of age. Conclusions: Despite high vaccination coverage, pertussis is circulating in Algeria. Most infections occur in unvaccinated infants <6 months of age, with mothers as the main source of infection. An adolescent/adult booster should be considered. Adoption of sensitive and specific laboratory tests would improve pertussis diagnosis and surveillance.

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Section: Incidence Of Pertussis Infectionsupporting

confidence: 82%

Section: Laboratory Findingssupporting

confidence: 49%

Section: Pertussis Confirmed Case Patientsmentioning

confidence: 71%

Section: Pertussis-confirmed Case Contactsmentioning

confidence: 99%

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Pertussis in north-central and northwestern regions of Algeria

Benamrouche

Maamar

Lazri

et al. 2016

J Infect Dev Ctries

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“…As culture failure does not exclude a diagnosis of pertussis and using this procedure alone to diagnose whooping cough is likely to lead to underdiagnosis of this infection. 18 Although, 21 cases proved by culture had received antibiotic prior to taking culture their antibiotic might not be effective. This study indicates that 47.6% of confirmed cases were unvaccinated and 28.6% were partially vaccinated according to their age.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of clinically suspected pertussis in children attending Rapareen Teaching Hospital in Erbil Governorate

Chlalabi

Alkhateeb

Dzayee

2015

ZJMS

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Virus Coinfection is a Predictor of Radiologically Confirmed Pneumonia in Children with Bordetella pertussis Infection

Jiang

Chen

et al. 2020

Infect Dis Ther

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Introduction This study aimed to prospectively investigate the burden of pertussis in southeast Chinese children hospitalized with lower respiratory tract infection (LRTI) during a pertussis outbreak and to compare the outcomes of Bordetella pertussis infection with or without virus coinfections. Methods Children < 24 months of age hospitalized with LRTI were prospectively enrolled from January 2017 to December 2019. Demographic and clinical information were recorded, and respiratory tract samples were tested for the presence of B. pertussis and ten common viruses by polymerase chain reaction (PCR). Results Bordetella pertussis PCR was positive in 6.1% (202/4287) of the patients. Only 146 (72.3%) B. pertussis infections met the Centers for Disease Control and Prevention case definition for pertussis. Among the 202 subjects with B. pertussis infections, 81 (40.1%) were coinfected with at least 1 respiratory virus, with human rhinovirus being the most commonly detected virus (25.7%). No differences in clinical severity were observed between children with single B. pertussis infection and those with virus coinfection [odds ratio (OR) 0.75; 95% confidence interval (CI) 0.39–1.44]. However, children with virus coinfection were significantly more likely to present with radiologically confirmed pneumonia than those with a single B. pertussis infection (OR 2.62; CI 1.39–4.91). Conclusions Bordetella pertussis infection contributed to a high proportion of LRTI hospitalizations among southeast Chinese children. There were no significant differences in clinical severity between children with virus coinfection and single B. pertussis infection, although children coinfected with virus coinfection presented with pneumonia more frequently than those with single B. pertussis infection. Electronic supplementary material The online version of this article (10.1007/s40121-020-00376-5) contains supplementary material, which is available to authorized users.

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Prevalence of Bordetella pertussis and Bordetella parapertussis infections in Tunisian hospitalized infants: results of a 4-year prospective study

Cited by 44 publications

References 73 publications

Pertussis in north-central and northwestern regions of Algeria

Pertussis in north-central and northwestern regions of Algeria

Evaluation of clinically suspected pertussis in children attending Rapareen Teaching Hospital in Erbil Governorate

Virus Coinfection is a Predictor of Radiologically Confirmed Pneumonia in Children with Bordetella pertussis Infection

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