Prevalence of bovine viral diarrhea virus in dairy cattle herds in eastern China

Hou, Peili; Zhao, Guimin; Wang, Hongmei; He, Hongbin

doi:10.1007/s11250-018-1751-z

Cited by 34 publications

(25 citation statements)

References 44 publications

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“…In China, BVDV-1a and -1c have been commonly detected in different regions of China. Recently, BVDV-1c (7/9) and BVDV-1a (1/9) strains were detected from 36 herds of dairy cattle in 5 provinces in eastern China [ 29 ]. A recent analysis of 119 BVDV sequences obtained from 92 dairy farms showed that subgenotypes of BVDV-1a ( n = 37, 31.09%), BVDV-1c ( n = 34, 28.57%) and BVDV-1 m ( n = 25, 21.01%) were predominant in 19 provinces of China in 2017 [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular detection and genotyping of bovine viral diarrhea virus in Western China

Chang

Liú

et al. 2021

BMC Vet Res

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Background Bovine viral diarrhea virus (BVDV) is an important global viral pathogen of cattle and other ruminants. To survey the infection rate and genetic diversity of BVDV in western China, a total of 1234 serum samples from 17 herds of dairy cattle, beef cattle and yak in 4 provinces were collected in 2019. Results All the 1234 serum samples were screened individually for BVDV by RT-PCR. Our results demonstrated that the average positive rate of BVDV was 7.2% (89/1234) in animals and 82.4% (14/17) in herds. Thirteen BVDV strains were isolated from RT-PCR positive clinical samples and they were all NCP biotype. BVDV-1a and 1c subgenotypes were identified from 22 selected virus isolates in 14 BVDV-positive herds. These results confirmed that BVDV-1a and BVDV-1c were circulating in western China, similar to the BVDV epidemics in cattle in other regions of China. Conclusions This study provides data for monitoring and vaccination strategies of BVDV in western China.

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Section: Discussionmentioning

confidence: 99%

Molecular detection and genotyping of bovine viral diarrhea virus in Western China

Chang

Liú

et al. 2021

BMC Vet Res

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“…BVDV is one of the most important viruses affecting bovine species throughout the world (1)(2)(3)(4). It is a complex cocktail of two strains of the virus inducing various clinical syndromes of the affected animals (5).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on the Bovine Viral Diarrhea Virus Molecular Pathogenesis, Immune Response, and Vaccines Development

et al. 2021

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The bovine viral diarrhea virus (BVDV) consists of two species and various subspecies of closely related viruses of varying antigenicity, cytopathology, and virulence-induced pathogenesis. Despite the great ongoing efforts to control and prevent BVDV outbreaks and the emergence of new variants, outbreaks still reported throughout the world. In this review, we are focusing on the molecular biology of BVDV, its molecular pathogenesis, and the immune response of the host against the viral infection. Special attention was paid to discuss some immune evasion strategies adopted by the BVDV to hijack the host immune system to ensure the success of virus replication. Vaccination is one of the main strategies for prophylaxis and contributes to the control and eradication of many viral diseases including BVDV. We discussed the recent advances of various types of currently available classical and modern BVDV vaccines. However, with the emergence of new strains and variants of the virus, it is urgent to find some other novel targets for BVDV vaccines that may overcome the drawbacks of some of the currently used vaccines. Effective vaccination strategy mainly based on the preparation of vaccines from the homologous circulating strains. The BVDV-E2 protein plays important role in viral infection and pathogenesis. We mapped some important potential neutralizing epitopes among some BVDV genomes especially the E2 protein. These novel epitopes could be promising targets against the currently circulating strains of BVDV. More research is needed to further explore the actual roles of these epitopes as novel targets for the development of novel vaccines against BVDV. These potential vaccines may contribute to the global eradication campaign of the BVDV.

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“…Pestivirus A (BVDV-1), Pestivirus B (BVDV-2), and Pestivirus H (HoBi-like Pestivirus) are the major pestiviruses infecting bovine species (ICTV 2019). Furthermore, there are at least 23 subgenotypes of BVDV-1 (1a-1w) and four subgenotypes of BVDV-2 (2a-2d) (Deng et al 2020, Hou et al 2019. BVDV can exist in two different biotypes based on its effects on infected cell cultures: cytopathic (cp) and non-cytopathic (ncp) (Baker 1995).…”

Section: Introductionmentioning

confidence: 99%

Persistent bovine viral diarrhea virus subgenotype 1d infection in dairy heifer calves born within 38 days interval

Zucoloto¹,

Fritzen²,

Lorenzetti³

et al. 2021

Preprint

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Bovine viral diarrhea virus (BVDV) causes a significant economic impact on the beef and dairy industries worldwide. Fetal infection with a non-cytopathic strain may lead to the birth of persistently infected (PI) offspring, the main event in the epidemiological chain of BVDV infection. This report describes the birth of 10 PI dairy calves from Brazil and the infecting BVDV subgenotype. Serum and blood samples were collected from 10 cows and 10 calves; all 10 calves were previously deemed BVDV positive by the ear notch rapid test. Serum samples were used in the virus neutralization technique to detect anti-BVDV antibody. Blood samples were used to detect BVDV RNA using the reverse transcription polymerase chain reaction (RT-PCR) assay of the 5' UTR and Npro genes. All 10 cows were negative for BVDV RT-PCR, while all 10 calves were RT-PCR positive. Phylogenetic analyses were performed and the strain was classified as BVDV-1d. High titers of BVDV-specific antibodies in the serum of cows indicated recent circulation of BVDV in the dairy herd, whereas calves presented intermediate, low, or no anti-BVDV-1a antibody titers. The monitoring of circulating BVDV subgenotypes and the detection of PI animals is of great importance in disease control, and regular vaccination alone is insufficient to prevent BVDV infection.

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Prevalence of bovine viral diarrhea virus in dairy cattle herds in eastern China

Cited by 34 publications

References 44 publications

Molecular detection and genotyping of bovine viral diarrhea virus in Western China

Molecular detection and genotyping of bovine viral diarrhea virus in Western China

Recent Advances on the Bovine Viral Diarrhea Virus Molecular Pathogenesis, Immune Response, and Vaccines Development

Persistent bovine viral diarrhea virus subgenotype 1d infection in dairy heifer calves born within 38 days interval

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