Prevalence of Calcification of the Mitral Valve Annulus in Patients Undergoing Surgical Repair of Mitral Valve Prolapse

Fusini, Laura; Ali, Sarah; Tamborini, Gloria; Muratori, Manuela; Gripari, Paola; Maffessanti, Francesco; Celeste, Fabrizio; Guglielmo, Marco; Claudia, C.; Alamanni, Francesco; Zanobini, Marco; Pepi, Mauro

doi:10.1016/j.amjcard.2014.03.013

Cited by 52 publications

(37 citation statements)

References 26 publications

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“…From patients taken to the operating room, 93 % of patients with MAC associated with BD receive mitral valve repair while the other 7 % acquire mitral valve replacement. While mitral valve replacement is more common with FED, patients with MAC had similar rates of replacement regardless if from FED or BD [24].…”

Section: Mitral Valve Replacementmentioning

confidence: 68%

“…Among patients with BD, 70 % of patients without mitral annulus calcification (MAC) are male; 47 % of patients with MAC were male. This suggests that female patients with BD tend to present with MAC [24].…”

Section: Clinical Presentationmentioning

confidence: 92%

“…Hypertension is more associated with mitral valve calcification in FED rather than BD (P = 0.004). Although 66 % of patients with FED did not have coronary artery involvement, 31 % did have two coronary arteries involved [24].…”

Section: Fibroelastic Deficiency Versus Barlow's Diseasementioning

confidence: 98%

“…Diabetes mellitus, dyslipidemia, and smoking had no statistical significance in terms of presence of mitral annulus calcification in patients with BD. Eighty-three percent of patients with mitral valve calcification associated with BD had no coronary artery involvement [24].…”

Section: Pathologic Findingsmentioning

confidence: 99%

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Current Discoveries and Interventions for Barlow’s Disease

Siordia

2016

Curr Cardiol Rep

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Section: Mitral Valve Replacementmentioning

confidence: 68%

Section: Clinical Presentationmentioning

confidence: 92%

Section: Fibroelastic Deficiency Versus Barlow's Diseasementioning

confidence: 98%

Section: Pathologic Findingsmentioning

confidence: 99%

See 2 more Smart Citations

Current Discoveries and Interventions for Barlow’s Disease

Siordia

2016

Curr Cardiol Rep

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“…The adjecent leaflet and myocardial tissue could be affected by the calcification process as well 1,2 . Therefore, the calcified po-sterior annulus is not a rare finding in the Barlow patients 3 and makes already complex reconstructive surgery more demanding. This is a case report of a patient who underwent a succesful mitral repair surgery in spite of excessive posterior leaflet and annular calcifications.…”

Section: Introductionmentioning

confidence: 99%

Reconstructive surgery of an extremely calcified mitral valve in Barlow disease patient: A case report

et al. 2019

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Introduction. Mitral valve calcifications are frequent finding in Barlow disease. This is making mitral repair surgery even more demanding in already complex valve pathology. Case report. A fifty-five-year-old Barlow disease patient underwent a mitral repair surgery due to posterior leaflet prolapse at P2 level and extensive posterior leaflet and annular calcifications as well. The prolapsed scallop was resected, while P1 and P3 scallops were detached from the annulus. After complete posterior annulus decalcification, so formed the large atrio-ventricular defect was reconstructed with the autologous pericardial patch and double suture line technique. The P1 and P3 segments were reattached there by the sliding technique and sutured with no strain. Annuloplasty was performed with a saddle rigid ring No 36. The patient was discharged nine days after the surgery with just a trace of mitral regurgitation. Conclusion. Annular decalcification and reconstruction in the patients with calcified Barlow mitral disease is neccessary for safe and durable mitral valve surgical repair.

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Impact of mitral intervention on outcomes of patients with mitral valve dysfunction and annulus calcification

Kato

Pellikka

Scott

et al. 2022

Cathet Cardio Intervent

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Objectives To compare all‐cause mortality in patients with mitral annulus calcification (MAC) and severe mitral valve dysfunction (MVD) who received standard mitral intervention versus no intervention. Background Patients with MAC often have high surgical risk due to advanced age, comorbidities, and technical challenges related to calcium. The impact of a mitral intervention on outcomes of patients with MAC and severe MVD is not well known. Methods Retrospective review of patients with MAC by transthoracic echocardiography (TTE) in 2015 at a single institution. Patients with severe mitral stenosis (MS) or regurgitation (MR) were analyzed and stratified into two groups: surgical or transcatheter intervention performed <1 year after the index TTE, and no or later intervention. The primary endpoint was all‐cause mortality. Results Of 5502 patients with MAC, 357 had severe MVD (MS = 27%, MR = 73%). Of those, 108 underwent mitral intervention (surgery = 87; transcatheter = 21). They were younger (73 ± 11 vs. 76 ± 11 years, p < 0.01) and less frequently had cardiovascular diseases compared with no‐intervention. Frequency in women was similar (45% vs. 50%, p = 0.44). During median follow‐up of 3.2 years, the intervention group had higher estimated survival than those without intervention (80% vs. 72% at 1 year and 55% vs. 35% at 4 year, p < 0.01). Adjusted for age, eGFR, LVEF < 50%, and pulmonary hypertension, mitral intervention was an independent predictor of lower mortality (hazard ratio = 0.66, 95% confidence interval 0.43–0.99, p = 0.046). Conclusion Patients with MAC and severe MVD who underwent mitral intervention <1 year from index TTE had lower mortality than those without intervention. Mitral intervention was independently associated with lower mortality.

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Prevalence of Calcification of the Mitral Valve Annulus in Patients Undergoing Surgical Repair of Mitral Valve Prolapse

Cited by 52 publications

References 26 publications

Current Discoveries and Interventions for Barlow’s Disease

Current Discoveries and Interventions for Barlow’s Disease

Reconstructive surgery of an extremely calcified mitral valve in Barlow disease patient: A case report

Impact of mitral intervention on outcomes of patients with mitral valve dysfunction and annulus calcification

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