Prevalence of Candida Infection in Patients with Type 2 Diabetes Mellitus in Sari, North of Iran

Kamali, Mohadeseh; Sarvtin, Mehdi Taheri; Parsanasab, Hassan

doi:10.13005/bpj/996

Cited by 5 publications

(3 citation statements)

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“…In the present study patients with diabetes had prevalence rate of 31.8%, which was noted to be higher than the study reported by Kamali et al, (17%). 4 In this study Covid along with diabetes have a high prevalence rate of 32.6% which was similar to the study of J. Katz. 20 Covid play as game changer role because it interfere with T cells causing decreased immunity leading to opportunistic candida infection.…”

Section: Discussionsupporting

confidence: 89%

“…3 Common predisposing factors for Candidiasis are diabetes, malignancy and prolonged use of antibiotics. 4 Candida also occurs as commensal flora in healthy individuals on mucosal oral cavity, Gastro intestinal tract, vagina etc. With changes in environmental and host conditions this commensal can act as endogenous opportunistic pathogen.…”

Section: Prevalence Of Candida Infection In Covid-19 Pandemic: a Study From A Tertiary Care Center In Central Indiamentioning

confidence: 99%

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Prevalence of Candida infection in Covid-19 pandemic: A study from a tertiary care center in Central India

et al. 2021

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Background: Corona virus disease 2019 (COVID-19) infections may be associated with a wide range of bacterial and fungal co-infections. Candida and mucor are the common fungus encountered during this pandemic. Candida is one of the commonly encountered opportunistic fungi that cause superficial mucosal infections usually, but can invade tissue and produce life threatening infections. Candida species recognized as one of the major agent of hospital Acquired (nosocomial) fungal infections. Keeping this in background the current study was conducted. Aims and Objective: To estimate the prevalence of candida infection in tertiary care hospital of Indore. Materials and Methods: The present study was done in the period of one and half year. During this period all received clinical specimens like urine, sputum; high vaginal swab and pus suspected for fungal infection from Covid as well as non-Covid patients were processed according to standard protocol. The specimen was subjected to preliminary tests like wet mount, Gram’s stain, culture on sabourads dextrose agar (SDA) and Hichrome agar, germ tube test, sugar assimilation test and culture on Cornmeal agar (dalmau technique) for candida species were done. For statistical analysis Chi-square test was performed and p ≤ 0.05 was considered statistically significant. Results: The prevalence of Candidiasis was 0.86%. Non-albicans candida (65.9%) isolates was more than Candida albicans (34.07%). Among non-albicans species, C. tropicalis was 27.4% followed by C. glabrata 16.29%, C. krusei 15.55%,C. parapsilosis 5.92% and C. lusitenia 0.74% were the major isolates. Males were affected more than the females. In both the genders maximum patients were from the age group of >60 years. Maximum number of Candida isolates was from blood followed by urine, pus, sputum, vaginal swab and aural swab. Most common risk factors for candidiasis noted in this study was diabetes mellitus in both Covid as well as non-Covid patients. Conclusion: Non albicans candida are gradually increasing in India. Speciation of candida play an important role in preliminary treatment because different species is intrinsically resistant to different antifungal drugs and have different antifungal susceptibility pattern.

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Section: Discussionsupporting

confidence: 89%

Section: Prevalence Of Candida Infection In Covid-19 Pandemic: a Study From A Tertiary Care Center In Central Indiamentioning

confidence: 99%

Prevalence of Candida infection in Covid-19 pandemic: A study from a tertiary care center in Central India

et al. 2021

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“…Although previous studies have reported the prevalence of Candida species in oral mucosa of diabetic patients in different geographic regions of Iran, genotyping pattern of isolates is not well-studied yet. [ 31 32 33 ] To address this question, in the current study, we isolated and identified the Candida species of oral cavity of both diabetic patients and healthy nondiabetic subjects, which have mainly focused on the determination of genotyping of C. albicans (25S rDNA region) through polymerase chain reaction (PCR) (CA-INT) as well as on the production of enzymatic activities of Candida species.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Molecular Identification, and Genotyping of Candida Species Recovered from Oral Cavity among Patients with Diabetes Mellitus from Tehran, Iran

Mohammadi

Zarei

Roudbary

et al. 2022

Advanced Biomedical Research

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Background: Oral candidiasis (OC) has been noticed as a common mucous membrane infection in immunocompromised patients such as that diabetes. This study, focused on the genotyping of Candida albicans and enzymatic activities of Candida species recovered from oral mucosa among diabetes patients and healthy individuals. Materials and Methods: Specimens were obtained from oral mucosa of One-hundred and sixty patients with type 2 diabetic and 108 healthy individuals. All isolates were definitely identified by ribosomal DNA (rDNA) gene sequencinghHydrophobicity, hemolytic activities of Candida species and genotypes of C. albicans were determined through polymerase chain reaction (CA-INT). Results: , Eighty eight (55%) samples out of 160, were positive for Candida species in diabetic patients. Moreover, 79.5% (70/88) and 20.5% (18/88) isolates belonged to the C. albicans and non- albicans Candida species respectively. Three genotypes of C. albicans have recovered in diabetic patients: genotype A (71.42%), B (21.42%), and C (7.14%). In healthy individuals, 42.6% (46/102) Candida species recovered from oral cavity, with the highest prevalence of genotype A (76.6% of C. albicans ). Additionally, hydrophobicity and hemolytic activities from Candida species were significantly greater in diabetes patients than healthy nondiabetic subjects. Conclusion: Collectively, C. albicans was the most causative agent isolated from diabetes patients and non-diabetes healthy individuals. Genotype A, as the most remarkable genotype, should be mentioned in both groups. Higher potential hydrophobicity and hemolytic activities of Candida species in diabetic patients compared to healthy cases suggest these features triggering pathogenicity of OC in diabetes patients.

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Study of Candida species in various clinical specimens at UCMS-TH, Bhairahawa, Nepal

Ghimire¹,

Reddy

Raut³

2023

Preprint

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Introduction: The incidence of fungal infections has increased significantly in the recent times contributing to high rates of morbidity and mortality. Although being the normal flora of various parts of human body, Candida species are recognized as a major fungal pathogen causing both superficial and deep-seated infection in immunosuppressed patients. Increase in antimicrobial resistance recently has rendered treatment difficult due to restricted number of antifungal drugs. Methods: This is a descriptive cross-sectional study done for a period of 18 months at a tertiary care center. Ethical clearance was obtained from Institutional Review Committee with a referece number (UCMS/IRC/036/18). Two hundred isolates of Candida species were identified from various clinical samples by using phenotypic tests such as CHROM agar, sugar fermentation test, sugar assimilation test and germ tube test. Antifungal susceptibility test was performed for five drugs namely ketoconazole (10µg), fluconazole (10µg), itraconazole (10µg), nystatin (100µg) and amphotericin-B(20µg). All the statistical evaluation was done by using SPSS version 20.0 software (IBM Corp., Armonk, NY). Results: Among 200 isolates of Candida, the most frequently isolated species was C.albicanswhich was seen in 69% of total isolates followed by C.tropicalis, C.krusei, and C.dubliniensis. Maximum Candida isolates were from urine sample (41.5%) followed by sputum (22.5%). Amphotericin –B was found to be the most sensitive drug with a sensitivity of 97.1% whereas ketoconazole was the least sensitive drug with a sensitivity of 40.5% among the isolates. Conclusion: C.albicans were the major isolates in this study, however, there is an increased incidence of non- albicans Candida species. Antifungal susceptibility test revealed increased resistance to different antifungal drugs among Candida species. This may conclude that increase in resistant strains may lead to difficult management of Candida infection as there are very few antifungal agents available.

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Prevalence of Candida Infection in Patients with Type 2 Diabetes Mellitus in Sari, North of Iran

Cited by 5 publications

References 0 publications

Prevalence of Candida infection in Covid-19 pandemic: A study from a tertiary care center in Central India

Prevalence of Candida infection in Covid-19 pandemic: A study from a tertiary care center in Central India

Prevalence, Molecular Identification, and Genotyping of Candida Species Recovered from Oral Cavity among Patients with Diabetes Mellitus from Tehran, Iran

Study of Candida species in various clinical specimens at UCMS-TH, Bhairahawa, Nepal

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