Prevalence of carcinomain situin testicular biopsies of infertile Iranian men

Abstract

Almost all testicular germ cell tumours are proved to originate from carcinoma in situ cells. Infertility is one of the factors that increase the risk of carcinoma in situ. The reported prevalence for carcinoma in situ from different parts of the world is 0-3.7% in infertile men. This retrospective study was performed to determine the prevalence of carcinoma in situ in Iranian infertile men. We reviewed the testicular biopsies of 1153 infertile men at the pathology department of Avicenna Infertility Center. One hundred and fifty-one cases were suspicious of having carcinoma in situ. Immunohistochemical marker for placental alkaline phosphatase was employed to confirm the diagnosis of carcinoma in situ. Positive results were detected in 7 (0.6%) of 1153 cases (95% CI 0.24%-1.24%), 6 (0.94%) of which (95% CI 0.34%-2.04%) were under the age of 35 years (636 patients were in this age group). This study is the first study in Iran determining the prevalence of carcinoma in situ among the infertile Iranian men; the result is in the range of reports from other countries.

Fertility potential in adult men treated for uncorrected bilateral cryptorchidism: A systematic literature review and analysis of case reports

“…A study of 100 biopsies at the time of adult orchidopexy found no instances of malignancy 3 . Smaller series involving adult cryptorchid men report rates of GCNIS ranging from 2% to 23% 15,43,44 . Incidental GCNIS was seldom reported in our review and not addressed by our analysis, but in light of available literature, routine tissue sampling in men considering orchidopexy for improved fertility may afford a risk that outweighs the potential benefit.…”

Postnatal Germ Cell Development in the Cryptorchid Testis: The Key to Explain Why Early Surgery Decreases the Risk of Malignancy

“…All testes with later ITGCN were originally intraabdominally placed. 12 ITGCN was found in 0 to 8% in other studies on follow-up testicular biopsies from adult men having previous prepubertal orchiopexy because of cryptorchidism. 9,13,14 In contrast, ITGCN is found more rarely in series with prepubertal cryptorchid testes.…”

“…8,9 ITGCN is demonstrated in 2.0 to 3.2% of cryptorchid testis from young men who were not treated in childhood. 10,11 Recently, Soltanghoraee et al 12 found ITGCN in 1.7% of 182 men with testes biopsied because of infertility, and all with previous orchiopexy because of cryptorchidism. All testes with later ITGCN were originally intraabdominally placed.…”

Long-Term Follow-Up after Treatment of Cryptorchidism

“…Immunohistochemical staining was not used in that study, which may explain why they did not diagnose any ITGCN case at all. Soltanghoraee et al 35 reviewed testicular biopsies of 1,153 infertile men. One hundred and ninety patients had a history of unilateral or bilateral cryptorchidism, 127 had undergone orchidopexy (the age of orchidopexy was known only in 95 patients (between 4-48 years of age).…”