Prevalence of Cardiac Abnormalities in Children with Chronic Kidney Disease: A Cross-sectional Study from a Developing Country

Ehsan, Afshan; Aziz, Madiha; Lanewala, Ali; Mehmood, Aftab; Hashmi, Seema

doi:10.4103/1319-2442.318553

Cited by 3 publications

(4 citation statements)

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“…DISCUSSION Twenty to forty percent of patients with heart failure have anemia, making it one of the leading causes of morbidity and mortality worldwide and a significant socioeconomic concern in the healthcare system. Concurrent renal failure is one potential confounder that could explain the increased prevalence of anemia in heart failure patients [7]. Hepcidin has been recognized as the molecule responsible for anemia of inflammation over the previous 8 years.…”

Section: Resultsmentioning

confidence: 99%

Assessment of the Serum Hepcidin as a Biomarker of Iron Status in Pediatric Congestive Heart Failure

Shedeed,

Khalifa,

Mohammed

et al. 2023

Zagazig University Medical Journal

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Background: Hepcidin plays a vital role in controlling iron homeostasis. Functional iron deficiency, as well as anemia, are common in heart failure, and it is hypothesized that hepcidin plays a significant role in both conditions. This study aimed to assess the relationship between hepcidin and anemia with the correlation of cardiac functions among congestive heart failure (CHF) pediatric cases. Methods: Our case-control study was performed in the Pediatrics department at Zagazig University Hospital. It included 42 participants divided into Group I: 21 cases of congestive heart failure, and Group II: 21 healthy controls. Serum hepcidin level was assessed a mong all participants. Results: A statistically significant decrease was found in hepcidin levels among studied CHF cases (p<0.001). High statistically significant positive correlations were found between hepcidin level and hemoglobin, red blood cell (RBCs) count,serum iron and ejection fraction (EF) of the studied cases (p<0.001, 0.008, <0.001, <0.001 respectively). There was a higher statistically significant decrease in hepcidin level assessed among severe CHF cases (ROSS grade 4) than cases of grade II and III (p<0.001). The sensitivity of hepcidin level in the prediction of CHF was 95.2% at a level less than 30.8 with the ability to exclude 90.5% of healthy cases and 92.9% test accuracy. The sensitivity of hepcidin level in the prediction of severe CHF was 85.7% at a level less than 27.6 with the ability to exclude 78.6% of mild cases and 83.3% test accuracy. Conclusions: In children with congestive heart failure, serum hepcidin level is a promising biomarker for anemia, and it can predict the severity of heart failure.

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Section: Resultsmentioning

confidence: 99%

Assessment of the Serum Hepcidin as a Biomarker of Iron Status in Pediatric Congestive Heart Failure

Shedeed,

Khalifa,

Mohammed

et al. 2023

Zagazig University Medical Journal

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“…LVH was determined as LVMI. LVMI was calculated using the anatomically validated formula: LVM was calculated at end diastole by using the American Society of Echocardiography convention [4]: LV mass = 0.8 (1.04 ([LVIDD+PWTD+IVSTD] 3-[LVIDD])) +0.6g, Where LVIDD is the left ventricular internal diameter in diastole, PWTD is the posterior wall thickness in diastole, and IVSTD is the interventricular septal thickness in diastole. LVMI was measured as follow: LVMI = LVM/body surface area.…”

Section: Methodsmentioning

confidence: 99%

“…It includes left ventricular (LV) remodeling, concentric LV hypertrophy (LVH), and eccentric LVH. [4]. The third pathological form is arteriosclerosis -a large vessel disease.…”

Section: Introductionmentioning

confidence: 99%

Role of Serum Hepcidin Level in Predicting Anemia and Cardiovascular Morbidity in Children with Chronic Kidney Disease.

Sarhan

Hameed

Ebraheim

et al. 2022

GEGET

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Introduction:The risk of mortality for pediatric patients with severe chronic kidney disease (CKD) is 30fold higher than that for healthy patients of the same age. The main cause of death is cardiovascular disease (CVD), accounting for 25-50 % of deaths in children and young adults with childhood onset CKD. Aim of the study:To study serum hepcidin level and its role in anemia and cardiovascular dysfunction in children with CKD, either on hemodialysis (HD) or on conservative therapy. Methods: Serum samples were obtained from 20 healthy individuals and from 30 patients with CKD on regular dialysis (group I) and 20 patients with chronic kidney diseases on conservative therapy (group II).The levels of hemoglobin , serum ferritin, s. iron , TIBC, serum hepcidin, and echo parameters in form of fractional shortening (FS),l eft ventricular mass index (LVMI) and trans mitral to mitral annular early diastolic velocity ratio (E/Ea') ratio were determined and the correlation between them was studied. Results: There is a significant increase in the serum hepcidin levels in group I and group II than the control group. There was significant correlation between hepcidin and serum ferritin, s. iron, transferrin saturation, FS, LVMI, E/Ea' while there was a negative correlation between serum hepcidin and both hemoglobin and TIBC. Conclusion: Hepcidin level is a good biomarker for anemia and cardiac dysfunction in patients with chronic kidney disease.

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“…CKD reduces vitamin D activation in the kidneys, resulting in hypocalcemia, hyperphosphatemia, and prompting increased parathyroid hormone (PTH) production, causing SHP ( 20 ). A cross-sectional study of 106 pre-dialysis pediatric patients by Ehsan et al found an elevated percentage of increased PTH levels in patients with cardiac abnormalities, noting that increased PTH levels may contribute to LVH progression in pediatric CKD patients ( 21 ). Another analysis of 70 pediatric patients with late stages of CKD saw increased levels of PTH as CKD progressed and labeled hyperparathyroidism [intact PTH (iPTH) >88 pg/mL] as a non-traditional risk factor for adverse cardiac outcomes ( 22 ).…”

Section: Secondary Hyperparathyroidism (Shp) and Its Association With...mentioning

confidence: 99%

Hypertension monitoring on cardiac health outcomes

Subhash,

Satariano,

Doshi

et al. 2024

Transl Pediatr

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Prevalence of Cardiac Abnormalities in Children with Chronic Kidney Disease: A Cross-sectional Study from a Developing Country

Cited by 3 publications

References 0 publications

Assessment of the Serum Hepcidin as a Biomarker of Iron Status in Pediatric Congestive Heart Failure

Assessment of the Serum Hepcidin as a Biomarker of Iron Status in Pediatric Congestive Heart Failure

Role of Serum Hepcidin Level in Predicting Anemia and Cardiovascular Morbidity in Children with Chronic Kidney Disease.

Hypertension monitoring on cardiac health outcomes

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