Prevalence of celiac disease among the Iranian population: A systematic review and meta-analysis of observational studies

Ahadi, Zeinab; Shafiee, Gita; R, Razmandeh; Keshtkar, Abasali; M, Najafi Sani; Azemati, Bahar; Sanaei, Maryam; Heshmat, Ramin

doi:10.5152/tjg.2015.150191

Cited by 16 publications

(10 citation statements)

References 22 publications

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“…According to the result of a recent systematic review, CD is a common disease with a prevalence of 0.7 to 1% [1]. Its prevalence in Iran is also similar to that of the American and European populations [2]. A strict, life-long gluten-free diet (GFD) is the only available treatment for CD [3].…”

Section: Introductionmentioning

confidence: 99%

The Persian Translation and validation of the celiac disease quality of life questionnaire (CDQOL)

Nikniaz

Jafarabadi

Ghaffarifar

et al. 2021

Health Qual Life Outcomes

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Background Considering the importance of having a celiac disease-specific measure of the quality of life (QOL) in Persian, the present study aimed to translate the celiac disease quality of life questionnaire (CDQOL) into Persian and evaluate its psychometric properties. Methods In this cross-sectional study, the Forward–Backward translation method was used. The content validation ratio (CVR) and the content validity index (CVI) were used for content validity assessment. The construct validity was assessed by exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) on 220 celiac patients who were selected randomly from the celiac disease (CD) registry database. The correlations between the result of the Persian version of CDQOL (PCDQOL), self-rated QOL, and short form-36 (SF36) were analyzed using the Pearson correlation test. The internal consistency and test–retest reliability were measured through Cronbach’s alpha and intraclass correlation coefficient (ICC). Results In the present study, 220 celiac patients with a mean age of 35.54 ± 10.29 years participated. The mean CVI, CVR, and impact score of PCDQOL were 0.98, 0.96, and 4.82 respectively. Using EFA, four factors have extracted that had a good fit in CFA (Chi-square/DF = 1.74, RMSEA: 0.08, and CFI: 0.90, and NFI: 0.90). The results showed that there was a moderate to high correlation between PCDQOL, SF36 (r: 0.587, p = 0.02), and self-rated QOL (r: 0.64, p < 0.001). The questionnaire had high internal consistency (Cronbach alpha: 0.93) and test–retest reliability (ICC: 0.96 [0.86–0.99]). Conclusion The PCDQOL questionnaire could be used by physicians and nutritionists to assess HRQOL in celiac patients in Iran.

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Section: Introductionmentioning

confidence: 99%

The Persian Translation and validation of the celiac disease quality of life questionnaire (CDQOL)

Nikniaz

Jafarabadi

Ghaffarifar

et al. 2021

Health Qual Life Outcomes

View full text Add to dashboard Cite

show abstract

“…CD is a major public health concern all over the world and affects approximately 1% of the population of South America, Africa, Europe, and Asia [ 2 ] . This rate varies from 0.5% to 1.0% for Iranian population [ 3 ] .…”

Section: Introductionmentioning

confidence: 99%

The Predictive Value of Serum Cytokines for Distinguishing Celiac Disease from Non-Celiac Gluten Sensitivity and Healthy Subjects

Masaebi

Looha

Rostami-Nejad

et al. 2020

ibj

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Background: It has been established that the level of some inflammatory cytokines increases in CD and NCGS in comparison with healthy subjects. Therefore, the primary interest in our research was proposing an accurate tool to diagnose patients with CD and NCGS from healthy individuals in an Iranian population. Methods: The serum samples were examined in 171 participants, including 110 CD patients, 46 healthy individuals, and 15 NCGS. The commercial ELISA kits were used to detect the level of the following cytokines: IL-1, IL-6, IL-8, IL-15, and IFN-γ. The ROC curve analysis was applied to determine the optimal thresholds for high sensitivity, specificity, positive and negative predictive values of cytokines, as the indicators of CD, NCGS, and healthy control groups. Results: In NCGS group, the values of AUC for IL-1, IL-8, and IFN-γ were 71%, 78%, and 70%, respectively. To differentiate the CD and NCGS groups from the control group, IL-15 had the highest sensitivity (82.70%), specificity (56.50%), positive predictive value (81.98%), and negative predictive value (57.78%), followed by IL-8 with the highest sensitivity of 74.50%, specificity of 73.30%, and positive and negative predictive values of 95.35% and 30.21%, respectively. Conclusion: The obtained results demonstrate that IL-15 and IL-8 could be proposed as potential markers in their optimal cutoff points for distinguishing CD from the NCGS and the healthy control. Based on our findings, the evaluation of cytokine levels can be recommended as a useful tool for the diagnosis of CD and NCGS in a clinical practice.

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“…Studies in Iran have reported that the prevalence rates of CD range from 0.5% to 0.9% in northern and southern Iran (12)(13)(14). This study was designed to investigate the frequency of CD in patients with JIA and RA in southwestern Iran.…”

Section: Introductionmentioning

confidence: 99%

Screening of patients with juvenile idiopathic arthritis and those with rheumatoid arthritis for celiac disease in southwestern Iran

Moghtaderi¹,

Farjadian²,

Aflaki³

et al. 2016

Turk J Gastroenterol

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Prevalence of celiac disease among the Iranian population: A systematic review and meta-analysis of observational studies

Cited by 16 publications

References 22 publications

The Persian Translation and validation of the celiac disease quality of life questionnaire (CDQOL)

The Persian Translation and validation of the celiac disease quality of life questionnaire (CDQOL)

The Predictive Value of Serum Cytokines for Distinguishing Celiac Disease from Non-Celiac Gluten Sensitivity and Healthy Subjects

Screening of patients with juvenile idiopathic arthritis and those with rheumatoid arthritis for celiac disease in southwestern Iran

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