Prevalence of celiac disease among first degree relatives of Brazilian celiac patients

Almeida, Patrícia Lopes de; Gandolfi, Lenora; Modelli, Inês Cristina; Martins, Renato; Almeida, Rodrigo Coutinho de; Pratesi, Riccardo

doi:10.1590/s0004-28032008000100013

Cited by 31 publications

(41 citation statements)

References 32 publications

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“…The concurrently occurrence of CD and pernicious anemia and/or atrophic gastritis is rare (20) . However, in this study, (1) Group > 60 years phase II x 0-18 years and 19-60 years phase II: P = 0.083 Chi-square with Yates' correction FIGURE 2. Positivity to autoantibodies in relatives of phases I and II in relation to age (1) Parents phase II x siblings phase II: P = 0.0356 (2) Parents phase II x offsprings phase II: P = 0.002 Fisher FIGURE 1.…”

Section: Discussioncontrasting

confidence: 54%

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Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years

Nass

Kotze

Nisihara

et al. 2012

Arq. Gastroenterol.

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-Context -Autoimmune diseases are 3 to 10 times more frequently in patients with celiac disease and their relatives than in the general population. Objective -To investigate a broad spectrum of autoantibodies in celiac disease relatives from Southern Brazil, in a serological follow-up of 6-10 years, aiming to associate with other autoimmune diseases, degree of parentage, demographic and clinical data. Methods -Serum samples of 233 relatives were analyzed in two different phases: n = 186 in phase I (1997)(1998)(1999)(2000) and n = 138 (being 91 = follow-up group and 47 = newly tested) in phase II (2006II ( -2007. As controls, 100 unrelated individuals were evaluated. Autoantibodies to smooth muscle, mitochondrial, liver-kidney microssome, parietal cell and thyroid microssome were tested by indirect immunofluorescence. Results -A significant increase of autoantibodies, in both phases, was observed in the relatives when compared to the non-relatives (P = 0.0064), specifically to anti-thyroid microssome and anti-parietal cell. In both phases, the female/male proportion of autoantibodies was of 4:1 to 3:1 (P≤0.041). The frequency of autoantibodies amongst 1st and 2nd degree relatives was 11.8% and 9.68% in phase I and 4% and 6.67% in phase II. Conclusion -Celiac disease relatives presented other autoantibodies and serological screening is a useful instrument for identifying autoimmune diseases along the years.

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Section: Discussioncontrasting

confidence: 54%

“…This enteropathy shows a well-known familiar predisposition and a prevalence of 16% among first-degree relatives (1,6) . The risk is even greater in families with affected siblings carrying the human leukocyte antigen (HLA)-DQ2.…”

Section: Introductionmentioning

confidence: 99%

Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years

Nass

Kotze

Nisihara

et al. 2012

Arq. Gastroenterol.

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“…In the recent studies the prevalence among first-degree relatives varied between 2.6% to 9.5%, a range that can be consequence of methodological differences used in these studies and the genetic background of the distinct population valued (1,2,5,14,15) . Interesting to notice that our results were similar to those from a recent study conducted in another Portuguese region (Porto) by Andreia Oliveira et al (12) that revealed a prevalence of 2.6% among 268 first degree relatives.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies regarding screening of first degree relatives have shown prevalence of CD in the range of 2.8%-10% (1,3,5,12,15) . Madeira is an island of Portugal with 267,785 inhabitants, 53,988 under the age of 18 years.…”

Section: Introductionmentioning

confidence: 99%

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Celiac Disease in Children From Madeira Island and Its Prevalence in First Degree Relatives

Oliveira

Cabral

Ferreira

et al. 2014

Arq. Gastroenterol.

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ContextIt is well recognized that celiac disease is an immune-mediated systemic disorder highly prevalent among relatives of celiac patients.ObjectivesThe aim of this study is to determine the prevalence of celiac disease in a group of first degree relatives of celiac children, and to access the frequency of human leukocyte antigen HLA-DQ2 and DQ8 in celiac disease patients and their affected relatives.MethodsA survey was conducted of 39 children with celiac disease with follow-up in the Pediatric outpatient’s clinic of Dr. Nélio Mendonça Hospital, in Madeira Island, Portugal. Were invited 110 first degree relatives to undergo serological screen for celiac disease with IgA antibody to human recombinant tissue transglutaminase (IgA-TGG) quantification. In all seropositive relatives, small intestinal biopsy and HLA typing was recommended.ResultsHLA- typing was performed in 38 celiac patients, 28/74% DQ2 positive, 1/2% DQ8 positive and 9/24% incomplete DQ2. Positive IgA-TGG was found in five out of the 95 relatives, and CD was diagnosed in three of them. Three relatives had the presence of HLA-DQ2, two were DQ2 incomplete (DQB1*02).ConclusionsThe prevalence of celiac disease among first degree celiac patients´ relatives was 3.1%, 4.5 times higher than the general Portuguese population (0,7%) witch reinforces the need of extensive diagnostic screening in this specific group. HLA-DQ2 typing may be a tool in the diagnostic approach.

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Towards an individual screening strategy for first-degree relatives of celiac patients

et al. 2018

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Celiac disease (CD) is known to be more prevalent in first-degree relatives of patients. In this retrospective cohort study of 609 relatives between 1994 and 2016, we investigated the effect of sex, HLA type, and age at time of index celiac diagnosis. Pearson's chi-square test and Kaplan-Meier survival analysis were used as statistical analyses. CD screening was carried out for 427 relatives (70%), resulting in a prevalence of 15%. HLA typing in 335 relatives showed HLA-DQ2/DQ8 positivity in 87.5%. In 63% of children and all parents, celiac disease was diagnosed at first screening. It was diagnosed significantly more often in females, HLA-DQ2 homozygosity, and children (all p < 0.05). In children aged 0-1 year at time of index diagnosis, celiac disease was diagnosed after consecutive screening in 58%, after 3.9 ± 2.5 (max 10) years (p < 0.001).Conclusion: Future screening policies for relatives of celiac patients should include retesting, especially in HLA-positive relatives younger than 10 years of age. In addition, one-time celiac-specific antibody testing alone could be sufficient to rule out the disease in adolescent siblings and parents of newly diagnosed celiac patients. What is Known: • Celiac disease is more prevalent in first-degree relatives of celiac patients (risk 3-12%). • HLA-DQ2 homozygous sisters/daughters are at highest risk (25%). What is New: • If younger than 10 years of age, repeated testing is necessary in HLA-DQ2/DQ8-positive first-degree relatives when celiac disease is diagnosed in a family. • One-time celiac-specific antibody testing alone could be sufficient to rule out the disease in adolescent siblings and parents of newly diagnosed celiac patients.

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Prevalence of celiac disease among first degree relatives of Brazilian celiac patients

Cited by 31 publications

References 32 publications

Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years

Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years

Celiac Disease in Children From Madeira Island and Its Prevalence in First Degree Relatives

Towards an individual screening strategy for first-degree relatives of celiac patients

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