Prevalence of celiac disease in Iranian children with idiopathic short stature

Hashemi, Seyed Jalal; Hajiani, Eskandar; Shahbazin, Hbb; Masjedizadeh, Rahim; Ghasemi, Navab

doi:10.3748/wjg.14.7376

Cited by 21 publications

(26 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of CD was higher (35-59%) in the studies 11,[14][15][16][17][18] where either the endocrinal workup had been done and/or the sample was very small. In rest of the studies 10,13,[19][20][21][22][23][24] where the endocrinal causes had not been ruled out in the selected children and/or the sample size was relatively larger, the prevalence reported was lower (1.7-8.3%).…”

Section: Discussionmentioning

confidence: 85%

Screening children with severe short stature for celiac disease using tissue transglutaminase

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 85%

Screening children with severe short stature for celiac disease using tissue transglutaminase

et al. 2010

View full text Add to dashboard Cite

show abstract

“…19,20 Although in most of the cases early intervention with gluten free diet enable some catching up growth 21 , the real pathogenesis behind the short height related to CD is still not very clear. 22 …”

Section: Discussionmentioning

confidence: 99%

Adult Celiac Disease: Patients Are Shorter Compared with Their Peers in the General Population

Esmaeilzadeh¹,

Ganji²,

Goshayeshi³

et al. 2016

Middle East J Dig Dis

View full text Add to dashboard Cite

BACKGROUNDDelay in diagnosis of celiac disease (CD) occurs frequently, although its consequences are mostly not known. One of the presented symptoms in pediatric patients with CD is the short stature. However, far too little attention has been paid to physical features including height of adult patients with CD. This study was undertaken to evaluate whether patients suffering from CD are shorter in comparison with the general population without CD. As well, we evaluated probable correlations between demographic and physical features, main complains, serum anti tTG level, and intestinal pathology damage between short (lower quartile) versus tall stature (upper quartile) patients with CD.METHODSThis was a retrospective cross-sectional study on 219 adult patients diagnosed as having CD in the Celiac Disease Center, between June 2008 and June 2014 in Mashhad, Iran. The exclusion criteria were ages less than 18 and more than 60 years. Height was compared with a group of 657 age- and sex matched control cases from the healthy population. The probable influencing factors on height such as intestinal pathology, serum level of anti-tissue transglutaminase(anti-tTG), serum vitamin D, and hemoglobin level at the time of diagnosis were assessed and were compared in short (lower quartile) versus tall stature (upper quartile) patients with CD.RESULTS Both male (n=65) and female (n=154) patients with CD were shorter than their counterpart in the general population (males: 168.5±8.6 to 171.3±7.2cm, p <0.01 and females: 154.8±10.58 to 157.8±7.2 cm, p <0.01). Spearman linear correlation showed height in patient with CD was correlated with serum hemoglobin (p <0.001, r=0.285) and bone mineral density (p<0.001) and not with serum vitamin D levels (p =0.024, r=0.237), but was not correlated with anti-tTG serum levels (p=0.97). CD patients with upper and lower quartile of height in men and women had no significant difference in the anti-tTG level and degree of duodenal pathology(Marsh grade). Anemia as main complaint was more prevalent in shorter versus taller men.CONCLUSIONAdults with CD are shorter compared with healthy adults. There is a direct correlation between height and anemia and bone mineral density. This finding highlights the importance of early detection and treatment of CD.

show abstract

“…For instance; incidence of CD has been reported as high as 0.01%-0.5% and 1.2% of the total population in Sweden and England, respectively. Rates are higher in Arabian countries, with 0.5%-1.0% of the total population having CD [6,7,8].…”

Section: Iranian Studies On Celiac Diseasementioning

confidence: 99%

“…Sensitivity, specificity and PPV for IgA TTG antibodies were 88.6%, 94.2% and 88.6%, respectively. They concluded that the prevalence of celiac disease is high in patients with ISS and it is important to test all children with ISS for celiac disease by measuring serologic markers and performing an intestinal biopsy [8].…”

Section: Iranian Studies On Celiac Diseasementioning

confidence: 99%

“…In very young children (under two years old) blood tests can be unreliable and may need to be repeated at later times. Biopsy may give false negative results if an insufficient number of biopsies were taken or biopsies were not taken at the correct locations or optimally handled by the laboratory receiving the tissue [7,8]. Also, patients already on a gluten-free diet may have negative test results because of partial treatment and in that case, endoscopy and biopsies would need to be repeated after restarting a gluten containing diet, usually for at least four weeks [1,2,9].…”

Section: Celiac Disease Screeningmentioning

confidence: 99%

See 1 more Smart Citation

Celiac Disease Overview in Children by Focused on Iranian Studies

Tajik¹

2016

IJCD

View full text Add to dashboard Cite

In the past decade increased clinical awareness and improved tests has advanced owing to diagnosis of celiac disease in different parts the world. Celiac disease is now classified as common disorder which can present at any age with a wide-ranging of symptoms. The atypical presentations of celiac disease has increased over the past 2 decades and predominant in both adults and children. By now a gluten-free diet is the only method of celiac disease treatment. In this review article I have over viewed the celiac disease spectrum and present the different studies on celiac disease in children in Iran.

show abstract

Prevalence of celiac disease in Iranian children with idiopathic short stature

Abstract: We conclude that the prevalence of celiac disease is high in patients with ISS and it is important to test all children with ISS for celiac disease by measuring serologic markers and performing an intestinal biopsy.

Cited by 21 publications

References 28 publications

Screening children with severe short stature for celiac disease using tissue transglutaminase

Screening children with severe short stature for celiac disease using tissue transglutaminase

Adult Celiac Disease: Patients Are Shorter Compared with Their Peers in the General Population

Celiac Disease Overview in Children by Focused on Iranian Studies

Contact Info

Product

Resources

About