Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study

Casella, Giovanni; D’Incà, R.; Oliva, L.; Daperno, Marco; Saladino, Valeria; Zoli, Giorgio; Annese, Vito; Fries, Walter; Cortellezzi, Claudio

doi:10.1016/j.dld.2009.08.005

Cited by 74 publications

(53 citation statements)

References 31 publications

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“…Bu birlikteliğin araştırıldığı bir çalışmada çölyak hastalarında İBH prevalansının kontrol grubuna göre 10 kat artmış olduğu ancak İBH hastalarındaki çölyak hastalığı prevalansının kontrol grubu ile benzer olduğu saptanmıştır [22]. Benzer bir çalışmada İBH olanlarda genel popülasyona oranla çölyak hastalığı gelişme riskinde artış olmadığı bildirilmiştir [23]. Çölyak hastaları ve birinci derece akrabalarındaki inflamatuvar barsak hastalığı sıklığını araştıran bir çalışmada, bu hastalarda normal popülasyona oranla daha sık Crohn hastalığı tespit edildiği bildirilmiştir [24].…”

Section: Discussionunclassified

Clinical and Laboratory Features and Extraintestinal Manifestations of Celiac Disease in Adults

Akın¹

2012

Ann Clin Anal Med

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ÖzetAmaç: Çölyak hastalığı, glutene karşı gelişen immün yanıt sonucu ortaya çıkan otoimmün bir hastalıktır. Erişkindeki başlangıç bulgu sıklıkla diyare olmakla birlikte anemi, osteoporoz, nonspesifik transaminaz yüksekliği ve gelişme geriliği gibi bazı ekstraintestinal bulgularla da ortaya çıkabilir. Bu yazıda, erişkin çölyak hastalarımızın başvuru semptomları, ekstraintestinal bulguları ve eşlik eden hastalıkları incelenmiştir. Gereç ve Yöntem: Ocak 2007 ile Eylül 2010 arasında Süleyman Demirel Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı'nda çölyak hastalığı tanısı ile takip edilen 22 hasta retrospektif olarak incelendi. Hastaların başvurusundaki semptomlar, ekstraintestinal bulgular ve eşlik eden hastalıklar değerlendirildi. Bulgular: Hastaların 13'ü (% 59) kadın, 9'u (% 41) erkekti. Tanıdaki ortalama yaş 38,5 yıldı. En sık başvuru yakınması ishal ve halsizlik-kuvvetsizlikti. Hastaların hepsinde doku transglutaminazı ve/veya antiendomisyum antikorları pozitifti ve tanı histopatolojik olarak doğrulanmıştı. 17 hastada (% 77) demir eksikliği, 8 hastada (% 36) vitamin B12 eksikliği ve 6 hastada folik asit (% 27) eksikliği vardı. 8 hastada (% 36) karaciğer enzim yüksekliği mevcuttu. 4 kadın ve 1 erkek hastada osteoporoz, 2 hastada sensorimotor polinöropati saptanmıştı. 2 hastada büyüme-gelişme geriliği mevcuttu. 2 hastada otoimmün hipotiroidi, 1 hastada Tip 1 diyabetes mellitus saptanmıştı. Bir hastada eş zamanlı Crohn hastalığı tanısı konulmuştu. Sonuç: Erişkinlerde çölyak hastalığı ekstraintestinal bulgular ile de ortaya çıkabilir. Özellikle nedeni açıklanamayan demir eksikliği anemisinde ve hafif-orta derecede transaminaz yüksekliklerinde çölyak hastalığı da akla getirilmelidir. Kronik diyaresi olan her hastada çölyak hastalığı da olabileceği düşünülmeli ve erken tanı ve uygun tedavi ile özellikle malabsorbsiyonun neden olduğu anemi, osteoporoz ve gelişme geriliği gibi komplikasyonlar önlenmelidir. Anahtar KelimelerÇölyak Hastalığı; Klinik Özellikler; Ekstraintestinal Bulgular Abstract Aim: Celiac disease an autoimmune disorder resulting from an immune response to the gluten in genetically predisposed patients. Although, diarrhea is the most common finding at presentation in adults, disease may present with extraintestinal manifestations such as anemia, osteoporosis, elevated transaminase levels and growth retardation. In this article, symptoms, extraintestinal manifestations and coexistence with other autoimmune disorders of adult patients with celiac disease were evaluated. Material and Method: 22 patients whose followed with the diagnosis of celiac disease in Suleyman Demirel University Department of Gastroenterology, between January 2007 and Semptember 2010, were evaluated retrospectively. Symptoms, extraintestinal manifestations and coexistence with other autoimmune disorders of patients at presentation were investigated. Results: 13 (59%) of all cases were female and 9 (41%) were male. Mean age at presentation was 38,5 years. Most common complaints were diarrhea and weakness . Tissue transglutam...

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Section: Discussionunclassified

Clinical and Laboratory Features and Extraintestinal Manifestations of Celiac Disease in Adults

Akın¹

2012

Ann Clin Anal Med

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“…Cassella et al (21) in their Italian study found the risk for ce liac disease to be lower in individuals with inflammatory bowel disease than in the general po p ulation. None of our patients with celiac disease had concomitant inflammatory bowel disease, however, 10% of our subjects in whom celiac disease was excluded had ulcerative colitis and 10% had Crohn's disease.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of IGA Anti-Tissue Transglutaminase Antibody Testing in Celiac Disease

Eremić¹,

Đerić²,

Hadnađev³

2012

Journal of Medical Biochemistry

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Diagnostic Accuracy of IGA Anti-Tissue Transglutaminase Antibody Testing in Celiac DiseaseContemporary guidelines for the first-line diagnosis of celiac disease recommend determination of IgA anti-tissue transglutaminase antibodies or IgA antiendomysial antibodies, as well as total serum IgA antibodies. The aim of our study was to assess the validity and clinical significance of serological testing for IgA anti-tissue transglutaminase antibodies in the diagnosis of celiac disease, and to investigate the presence of malabsorption symptoms in celiac patients. IgA anti-tissue transglutaminase antibody testing was performed in 50 subjects with clinically suspected celiac disease (21 men and 29 women). All subjects underwent endoscopy with small intestine biopsy. Celiac disease was confirmed by histopathological findings in four subjects, whereas the IgA anti-tissue transglutaminase test was positive in three subjects. The IgA anti-tissue transglutaminase test showed sensitivity of 75% and specificity of 100%. There were significant differences between men with biopsy-confirmed and excluded celiac disease in the erythrocyte parameters MCV (96.5±7.7 vs. 78.6 ±11.3; p<0.05), MCH (36.9±4.6 vs. 25.9±4.9; p<0.01), and MCHC (382.5±16.3 vs. 326.9±19.1; p<0.005), as well as in the levels of total protein (47.5 ±16.3 vs. 68.3 ± 7.6; p<0.01) and albumins (24.6±9.5 vs. 42.1 ± 6.9; p<0.01). In addition, HDL-cholesterol levels were significantly lower in men with biopsy-confirmed celiac disease (0.42.±0.12 vs. 0.90±0.30; p<0.05). Our results show a high correlation between IgA anti-tissue transglutaminase testing and endoscopy with biopsy as the gold diagnostic standard.

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“…found the prevalence of celiac disease in IBD was comparable with that in controls. Assumed cause of this difference is that the increased intestinal permeability in CeD may lead to increased antigen presentation and therefore generation of autoantibodies or increased bacterial translocation, which has been involved in IBD as a pathogenic mechanism [9,10] . Genetic studies have identified four shared risk chromosomal loci: PTPN2, IL18RAP, TAGAP, and PUS10 in both diseases [11] .…”

Section: Discussionmentioning

confidence: 99%

Celiac disease association with other autoimmune disorders: Three case reports

Kocsis

Csaplár²,

Jocsak

et al. 2014

CRIM

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Background: A 15 year period retrospective study at our celiac centre (Semmelweis University 2nd Department of Internal Medicine) has found, that 91 out of 248 coeliac patients (20 male, 71 female) also suffered from at least one autoimmune disease associated with celiac disease. The objective of the following case reports is to demonstrate the protean faces of celiac disease and the association tendency with other autoimmune disorders.Case presentation: 34-years old male patients presented with peripheral neuropathy. Results of electrophysiological studies were normal. Immunpanel examination was detected elevated tissue Transglutaminase antibodies levels. Duodenal biopsy revealed villous atrophy. Patient was started on strict gluten free diet and one year later he had almost complete recovery. 46-years-old male diagnosed with Dermatitis herpetiformis Duhring and celiac disease 20-years ago. In the last few years in spite of the gluten-free diet, he newly presented intestinal symptoms and chronic iron deficiency anaemia. The control tissue Transglutaminase antibodies, and duodenal biopsies were negative. Colonoscopy found inflammation in terminal ileum; video capsule endoscopy detected multiple ulcerative lesions in whole small bowel. The results confirmed the diagnosis of Crohn's disease. A 22-years old female patient diagnosed with celiac disease during the puerperium. The patient had muscles weakness, swallowing dysfunction, diplopia and generalized fatigue too. Muscle biopsies were normal. The electromyography was specific to myasthenia gravis. Computed tomography found thymus persistent. After tymectomy she showed good clinical response to immunosuppressant and cholinesterase inhibitor therapy. Conclusion:Autoimmune disorders have often been associated with celiac disease.

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Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study

Cited by 74 publications

References 31 publications

Clinical and Laboratory Features and Extraintestinal Manifestations of Celiac Disease in Adults

Clinical and Laboratory Features and Extraintestinal Manifestations of Celiac Disease in Adults

Diagnostic Accuracy of IGA Anti-Tissue Transglutaminase Antibody Testing in Celiac Disease

Celiac disease association with other autoimmune disorders: Three case reports

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