Prevalence of Celiac Disease in Down Syndrome in the United States

Zachor, Ditza A.; Mroczek‐Musulman, Elizabeth; Brown, Pamela Allen

doi:10.1097/00005176-200009000-00014

Cited by 64 publications

(48 citation statements)

References 20 publications

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“…29 In regard to mental retardation, both epilepsy with occipital brain calcifications and Down syndrome were previously reported in CD. 12,30,31 In contrast to these findings, the association between CD and autism is poor and probably does not exist. 32 Cerebellar ataxia has been well recognized in patients with CD, primarily in adults.…”

Section: Discussionmentioning

confidence: 71%

Range of Neurologic Disorders in Patients With Celiac Disease

et al. 2004

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ABSTRACT. Objective. During the past 2 decades, celiac disease (CD) has been recognized as a multisystem autoimmune disorder. A growing body of distinct neurologic conditions such as cerebellar ataxia, epilepsy, myoclonic ataxia, chronic neuropathies, and dementia have been reported, mainly in middle-aged adults. There still are insufficient data on the association of CD with various neurologic disorders in children, adolescents, and young adults, including more common and "soft" neurologic conditions, such as headache, learning disorders, attention-deficit/hyperactivity disorder (ADHD), and tic disorders. The aim of the present study is to look for a broader spectrum of neurologic disorders in CD patients, most of them children or young adults.Methods. Patients with CD were asked to fill in a questionnaire regarding the presence of neurologic disorders or symptoms. Their medical charts were reviewed, and those who were reported as having neurologic manifestations underwent neurologic examination and brain imaging or electroencephalogram if required. Their neurologic data were compared with that of a control group matched for age and gender.Results. Patients with CD were more prone to develop neurologic disorders (51.4%) in comparison with control subjects (19.9%). These disorders include hypotonia, developmental delay, learning disorders and ADHD, headache, and cerebellar ataxia. Epileptic disorders were only marginally more common in CD. In contrast, no difference was found in the prevalence of tic disorders in both groups. Therapeutic benefit, with gluten-free diet, was demonstrated only in patients with transient infantile hypotonia and migraine headache.Conclusion. This study suggests that the variability of neurologic disorders that occur in CD is broader than previously reported and includes "softer" and more common neurologic disorders, such as chronic headache, developmental delay, hypotonia, and learning disorders or ADHD. Future longitudinal prospective studies might better define the full range of these neurologic disorders and their clinical response to a gluten-free diet. Pediatrics 2004;113:1672-1676; celiac disease, neurologic disorders, migraine, attention-deficit/hyperactivity disorder, hypotonia.ABBREVIATIONS. CD, celiac disease; ADHD, attention-deficit/ hyperactivity disorder.A lthough in the past celiac disease (CD) was primarily considered to be a gluten enteropathy, during the past 2 decades, its clinical concept has been expanded, and it is now considered a multisystem autoimmune disorder, 1 with most of the patients being asymptomatic, oligosymptomatic, or present with extraintestinal manifestations. 2 Among these extraintestinal manifestations, there is a growing body of publications that report neurologic conditions that are associated with CD. 3-12 Although earlier studies reported neurologic complications in patients with classical gluten enteropathy, some recent studies report neurologic disorders in asymptomatic CD patients. 13,14 Most of the patients who have CD and were reported ...

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Section: Discussionmentioning

confidence: 71%

Range of Neurologic Disorders in Patients With Celiac Disease

et al. 2004

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“…In Turner syndrome the prevalence is 4.1 to 8.1% [15]. For Williams syndrome is 8.2% [16], and it is about 12% in individuals with Down syndrome [17]. Celiac disease may be associated with other autoimmune conditions such as Type I Diabetes Mellitus, in which more than 8% of individuals present this disease [18,19] also being associated with eosinophilic esophagitis [20].…”

Section: Clinical Featuresmentioning

confidence: 99%

Systemic and Oral Aspects in Celiac Disease for Dentistry

Torres¹,

Marçal²,

Ponte³

et al. 2016

J. Dent. Sci. Ther

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“…The published studies about the incidence of celiac disease in Down's syndrome patients utilized different criteria of patient selection (Table II), and thus the study groups are heterogeneous and the results are A Au ut th ho or r, , d da at te e, , c co ou un nt tr ry y S Se el le ec ct ti io on n c cr ri it te er ri ia a o of f p pa at ti ie en nt ts s w wi it th h D Do ow wn n' 's s s sy yn nd dr ro om me e [22,30,31,35,36,38,[42][43][44]; there are few studies on the incidence of celiac disease in Down's syndrome patients conducted on the scale of a large region or country [32,39,40]. The only available multi-center study assessing the incidence of celiac disease, conducted on a group of Down's syndrome patients in a number that complies with the requirements of an epidemiological study, was performed by an Italian group.…”

Section: Ema -Anti-endomysial Antibodies Aga -Anti-gliadin Antibodiementioning

confidence: 99%

Are Down’s syndrome patients a risk group for celiac disease?

Nowak-Oczkowska¹,

Szaflarska-Popławska²,

Soroczyńska-Wrzyszcz³

2013

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K Ke ey y w wo or rd ds s: : celiac disease, Down's syndrome, incidence, screening. S Sł ło ow wa a k kl lu uc cz zo ow we e: : choroba trzewna, zespół Downa, częstość występowania, badania przesiewowe.A Ad dd dr re es ss s f fo or r c co or rr re es sp po on nd de en nc ce e: : Department and Clinic of Pediatrics, Allergology, and Gastroenterology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 9 Marii Skłodowskiej-Curie, 85-094 Bydgoszcz, Poland, phone: +48 52 585 48 50, fax: +48 52 585 40 86, e-mail: klped@cm.umk.pl Review paper/Artykuł poglądowy AbstractCeliac disease is a genetically determined enteropathy caused by permanent gluten intolerance. The factors considered as responsible for celiac disease are genetic and environmental factors, as well as auto-immunological processes which lead to chronic inflammation. There are reports in the literature that indicate co-occurrence of celiac disease with many diseases, and one of the reported risk groups of celiac disease is patients with the most frequent chromosome abnormalityDown's syndrome. Many societies and authors recommend screening of this group. StreszczenieCeliakia jest genetycznie uwarunkowaną enteropatią spowodowaną trwałą nietolerancją glutenu. Wśród czynników odpowiedzialnych za ujawnienie choroby trzewnej wymienia się czynniki genetyczne, środowiskowe oraz procesy autoimmunologiczne prowadzące do przewlekłych stanów zapalnych. W piśmiennictwie opisuje się współistnienie choroby trzewnej z wieloma jednostkami chorobowymi, a za jedną z grup ryzyka rozwoju celiakii uznaje się najczęstszą aberrację chromosomalną, jaką jest zespół Downa. Wiele towarzystw i autorów rekomenduje przeprowadzanie badań przesiewowych w tej grupie pacjentów.

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Prevalence of Celiac Disease in Down Syndrome in the United States

Cited by 64 publications

References 20 publications

Range of Neurologic Disorders in Patients With Celiac Disease

Range of Neurologic Disorders in Patients With Celiac Disease

Systemic and Oral Aspects in Celiac Disease for Dentistry

Are Down’s syndrome patients a risk group for celiac disease?

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