Prevalence of Celiac Disease in Patients With Iron Deficiency Anemia—A Systematic Review With Meta-analysis

Mahadev, SriHari; Laszkowska, Monika; Sundström, Johan; Björkholm, Magnus; Lebwohl, Benjamin; Green, Peter H.R.; Ludvigsson, Jonas F.

doi:10.1053/j.gastro.2018.04.016

Cited by 101 publications

(89 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In one meta-analysis, one of 31 patients with IDA was reported to have CD. 19 IDA was observed in 26%, folate deficiency in 12%, B12 deficiency in 5% of 405 patients according to Harper et al's 18 study. IDA and folic acid deficiency associated primarily with the effect of CD on the proximal small bowel mucosa are common findings, and B12 deficiency absorbed from terminal ileum is also another cause.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of adult celiac disease from a tertiary reference center: a retrospective analysis

Binicier

Tosun

2020

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

SUMMARY OBJECTIVE It has been observed that celiac disease (CD) is not restricted to a single type characterized by diarrhea but also has atypical, asymptomatic (silent), and latent forms. The prevalence of this autoimmune disease, which affects approximately 1% of the world, is estimated to be around 3%, including atypical and asymptomatic cases. In our study, we aimed to evaluate adult celiac patients. METHODS Between December 2008-2015, patients diagnosed with CD over the age of 18 years old were included in the study. Patients’ symptoms at admission, frequency and type of anemia, transaminase levels, and celiac antibody positivity, and autoimmune diseases diagnosed at follow up were evaluated retrospectively. RESULTS Of 195 patients, 151 (77.4%) were female. The mean age of the patients was 35.73 ± 12.19 years (range, 18-71 years). A hundred patients (51.3%) had gastrointestinal symptoms. At the time of admission, 118 patients (60.5%) had anemia, and 52 (26.7%) had hypertransaminasemia. During the mean follow-up period of 58 months (36-120 months), 84 (43.1%) of the patients presented at least one autoimmune disease, and this rate was 96.6% in individuals diagnosed above the age of 50 years. CONCLUSION In adult CD, resistant anemia, dyspepsia, and hypertransaminasemia are very common findings at the time of diagnosis, and the association with other autoimmune diseases, especially Hashimoto’s thyroiditis, is high.

show abstract

Section: Discussionmentioning

confidence: 92%

Evaluation of adult celiac disease from a tertiary reference center: a retrospective analysis

Binicier

Tosun

2020

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…28 Iron deficiency anemia is the most common extraintestinal feature of CD. 29 In a patient with iron deficiency anemia without any gastrointestinal symptoms, the prevalence of CD ranges from 3% to 9%, whereas those with gastrointestinal symptoms may have prevalence rates as high as 10% to 15%. 30 Celiac disease may be most overlooked in the population of menstruating women, which is the demographic more likely to get CD.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…70 Moreover, the strength of evidence supporting the recommendation for testing is variable among the accepted indications for clinical testing. Currently, case finding is recommended for the following: first-degree family members of an index case or both firstand second-degree relatives of sibling pairs with CD, 71 autoimmune thyroid disease, 72 Down or Turner syndrome, 73 unexplained elevation of serum transaminases, type 1 diabetes mellitus, diarrhea-predominant irritable bowel syndrome, IgA deficiency, growth stunting in children, unexplained iron deficiency anemia, 29 unexplained ataxia or neuropathy, premature metabolic bone disease, and infertility. 24…”

Section: Screening For CDmentioning

confidence: 99%

Celiac Disease

Oxentenko

Rubio–Tapia

2019

Mayo Clinic Proceedings

View full text Add to dashboard Cite

“…Diagnosis rates are increasing, which seems to be due to a true rise in incidence that requires greater awareness and early detection. In response to unknown environmental factors, it is believed that ingestion of gluten promotes an immunologically mediated small intestinal enteropathy in genetically susceptible individuals [3]. The disease primarily affects the small intestine; however, the clinical manifestations are large, with both intestinal and extra-intestinal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Is a Gluten-Free Diet Enough to Maintain Correct Micronutrients Status in Young Patients with Celiac Disease?

et al. 2020

View full text Add to dashboard Cite

The current study assesses whether the use of a gluten-free diet (GFD) is sufficient for maintaining correct iron status in children with celiac disease (CD). The study included 101 children. The celiac group (n = 68) included children with CD, with long (> 6 months) (n = 47) or recent (< 6 months) (n = 21) adherence to a GFD. The control group (n = 43) included healthy children. Dietary assessment was performed by a food frequency questionnaire and a 3-day food record. Celiac children had lower iron intake than controls, especially at the beginning of GFD (p < 0.01). The group CD-GFD >6 months showed a higher intake of cobalamin, meat derivatives and fish compared to that of CD-GFD <6 months (all, p < 0.05). The control group showed a higher consumption of folate, iron, magnesium, selenium and meat derivatives than that of children CD-GFD >6 months (all, p < 0.05). Control children also showed a higher consumption of folate and iron compared to that of children CD-GFD <6 months (both, p < 0.05). The diet of celiac children was nutritionally less balanced than that of the control. Participation of dietitians is necessary in the management of CD to guide the GFD as well as assess the inclusion of iron supplementation and other micronutrients that may be deficient.

show abstract

Prevalence of Celiac Disease in Patients With Iron Deficiency Anemia—A Systematic Review With Meta-analysis

Abstract: In a systematic review and meta-analysis, we found that approximately 1 in 31 patients with IDA have histologic evidence of CD. This prevalence value justifies the practice of testing patients with IDA for CD.

Cited by 101 publications

References 93 publications

Evaluation of adult celiac disease from a tertiary reference center: a retrospective analysis

Evaluation of adult celiac disease from a tertiary reference center: a retrospective analysis

Celiac Disease

Is a Gluten-Free Diet Enough to Maintain Correct Micronutrients Status in Young Patients with Celiac Disease?

Contact Info

Product

Resources

About