Prevalence of celiac disease in a cohort of women with unexplained infertility

Jackson, J. Edward; Rosen, Mitchell P.; McLean, Tracey; Moro, J.; Croughan, Mary S.; Cedars, Marcelle I.

doi:10.1016/j.fertnstert.2007.04.053

Cited by 24 publications

(28 citation statements)

References 17 publications

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“…The prevalence of CD in infertile women is 2%-6%, which is approximately 1% in the general population (20). On the other hand, there are studies reporting an absence of an increased prevalence (21). In the present study, four in five patients had positive anti-gliadin antibodies that have a low sensitivity and specificity; findings of CD could not be found in their histopathological examination.…”

Section: N (Couples) 65contrasting

confidence: 60%

Is there any relationship between unrecognized Celiac disease and unexplained infertile couples?

Karaca¹,

Yilmaz²,

Aktün³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Celiac Disease (CD) is a chronic autoimmune disease characterized by small intestinal malabsorbtion and diarrhea, triggered by the ingestion of food products containing gluten. There are studies reporting that some nutritional deficiencies and some factors related to immunity may cause a decrease in fertility as well as some problems in sperm parameters. The prevalence of CD in unexplained infertility (UEI) couples is not as high as that mentioned in some reports. There is no accurate knowledge about the prevalence of CD in a UEI couple. Materials and Methods: A total of 68 couples with UEI who were admitted at Türk Diyanet Vakfı 29 Mayıs Hospital Center of in vitro fertilization (IVF) between January and June 2014 were included in this prospective pilot study. The diagnosis of UEI was made with basic infertility tests. A history of CD was questioned in the initial evaluation. Anti-gliadin, anti-endomysial, and tissue transglutaminase antibodies as well as total IgA were tested. Gastroscopy was performed in patients with positive serologic tests. Histopathological CD diagnosis was made according to Marsh criteria. Results: The mean age of the study population was 33.40±4.59 years. Out of the 65 couples who were included into the study group, one of the five couples was positive for the autoantibodies (7.69%). Out of these 65 couples, none of them had autoantibody positivity at the same time in both partners. Anti-gliadin antibodies were found to be positive for two females out of five couples and in three male partners of the same group. Out of these five couples, only one male partner had all the antibodies as positive (1.5%). In the histopathological examination of patients with positive autoantibodies, only the patient in whom all autoantibodies were positive had findings compatible with Marsh IIIa gluten enteropathy. Only one couple had a diagnosis of CD (1.5%). Conclusion: In many studies, CD was shown to affect the reproductive system of women. CD may also cause a decrease in fertility in men by affecting sperm motility and androgen levels. Our study is based on a limited sample size. Our data should be confirmed in a larger cohort of subjects. These results suggest that investigation of both couples with a diagnosis of UEI may be more beneficial in clarifying the etiology.

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Section: N (Couples) 65contrasting

confidence: 60%

Is there any relationship between unrecognized Celiac disease and unexplained infertile couples?

Karaca¹,

Yilmaz²,

Aktün³

et al. 2015

Turk J Gastroenterol

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“…Of these, 395 were excluded, and eighteen potentially relevant studies were evaluated. Six studies were excluded because they did not fulfilled elegibility criteria: three studies lacked a control group (5,13,17) , a large population-based study (9) was not designed to compare infertility prevalence in celiac subjects and used U.S. general population as a control group; another study (20) used an inadequate control group (previously known prevalence of silent CD in the northen Sardinian population) and another one (7) assessed the risk of infertility only in male subjects and used Crohn's disease patients as control group. Finally, as shown in Figure 1, twelve studies were included for analysis.…”

Section: Resultsmentioning

confidence: 99%

“…There has been evidence indicating a link between CD and reproductive disorders, such as recurrent abortions (3) . The relationship between CD and infertility has been previously assessed by several studies, with contradictory results (13,20) . Hence, we sought to perform a systematic review and meta-analysis of current evidence on this particular subject.…”

Section: Introductionmentioning

confidence: 99%

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RISK OF INFERTILITY IN PATIENTS WITH CELIAC DISEASE: a meta-analysis of observational studies

Lasa¹,

Zubiaurre²,

Soifer³

2014

Arq. Gastroenterol.

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ContextCeliac disease is an autoimmune disorder of the small intestine associated with several extra-intestinal features, such as reproductive disorders. The relationship between celiac disease and infertility has been previously assessed, with conflicting results.ObjectivesWe seek to determine the relationship between celiac disease and infertility.MethodsData was extracted from case-control or cohort design studies from 1966 to December 2013 using the MEDLINE-Pubmed, EMBASE, LILACS and Cochrane Library databases. We analyzed two kinds of trials: those assessing the risk of infertility in subjects with already diagnosed celiac disease, and those evaluating the prevalence of undiagnosed celiac disease in subjects with a diagnosis of infertility.ResultsThe search yielded 413 potentially relevant studies for revision, 12 of which were finally included for analysis. A significant association was found between women with a diagnosis of infertility and undiagnosed celiac disease [OR 3.09 (95% CI 1.74-5.49)]. When considering those studies assessing the occurrence of infertility in subjects with already-diagnosed celiac disease, no difference was found between celiac disease patients and control subjects [OR 0.99 (0.86-1.13)].ConclusionsUndiagnosed celiac disease is a risk factor for infertility. Women seeking medical advice for this particular condition should be screened for celiac disease. Adoption of a gluten-free diet could have a positive impact on fertility in this group of patients.

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“…In 1970, Morris et al reported three celiac patients with infertility, who were able to give birth after dietary gluten restriction [1], establishing the possible relationship between these two entities, and the potential beneficial role of gluten free diet (GFD). On the contrary, Jackson et al described a cohort of women suffering from infertility that were tested for CD by means of serology [7]. The authors compared the prevalence of positive findings to the background rate in the general US population: they found that their cohort had a lower prevalence.…”

Section: Female Infertility In Celiac Diseasementioning

confidence: 99%

Celiac Disease and the Risk of Infertility

Olivera¹,

Lasa²

2016

IJCD

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Celiac Disease is a chronic inflammatory disease, caused by an abnormal immune response triggered by intestinal exposure to dietary gluten, the protein fraction of wheat, rye and barley, in genetically susceptible individuals. Among atypical presentations of Celiac Disease, reproductive disorders and adverse pregnancy outcomes have been reported. Infertility is defined as the impossibility of conceiving after 12 months of unprotected intercourse. It can be related to both male and female factors, with the latter subdivided into ovarian, tubal, endometrial or unexplained causes. Celiac Disease has been related to infertility, but the evidence is inconclusive. In this review, we discuss the effect of Celiac Disease in both male and female fertility, as well as the possible mechanisms that may be involved.

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Prevalence of celiac disease in a cohort of women with unexplained infertility

Cited by 24 publications

References 17 publications

Is there any relationship between unrecognized Celiac disease and unexplained infertile couples?

Is there any relationship between unrecognized Celiac disease and unexplained infertile couples?

RISK OF INFERTILITY IN PATIENTS WITH CELIAC DISEASE: a meta-analysis of observational studies

Celiac Disease and the Risk of Infertility

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