Prevalence of Celiac Disease in Patients with Autoimmune Thyroid Disease: A Meta-Analysis

Roy, Abhik; Laszkowska, Monika; Sundström, Johan; Lebwohl, Benjamin; Green, Peter H. R.; Kämpe, Olle; Ludvigsson, Jonas F.

doi:10.1089/thy.2016.0108

Cited by 74 publications

(49 citation statements)

References 74 publications

(124 reference statements)

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“…The high prevalence of CD among patients with type 1 diabetes mellitus (up to 13.5%) is probably due to clinical and pathogenic overlap [68], and symptoms are often modest or absent. The results partially represented in Table 3 and found in meta-analyses [69, 70] of high CD prevalence in children with Down syndrome (more than 5%) and autoimmune thyroid disorders (about 6%) should motivate screening for CD in these cohorts. CD is also common in patients who have a first- and second-degree kinship with persons with CD, at 10 and 2.6%, respectively [71-73].…”

Section: Screening Strategies In Paediatric Populationsmentioning

confidence: 99%

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Savvateeva

Erdes

Antishin

et al. 2018

Int Arch Allergy Immunol

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Coeliac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in genetically predisposed individuals. Identification of CD in clinical practice is often difficult due to the manifestation of non-specific symptoms and signs, so a relatively significant proportion of CD cases remain undiagnosed. Timely detection of the disease is necessary to provide an appropriate approach to control of the disease treatment, in order to avoid potential complications. This is even more important in the case of children and adolescents, to ensure their proper growth and development. In this review, we discuss the data on the current strategies for CD detection among paediatric populations and the role of questionnaire-based discovery of CD cases in the area of interest. We assume that mass screening is a preferable strategy for finding CD cases within the paediatric population because this could uncover symptomatic, oligosymptomatic, and asymptomatic CD cases. However, under conditions of limited financial resources, screening for CD in risk groups, members of which can be identified using questionnaires, is essential. The pros and cons of CD screening in paediatric populations are presented. These depend on a number of situational criteria (cost-effectiveness, lack of awareness), but screening is designed to improve the detection of the disease and therefore improve the quality of life of patients.

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Section: Screening Strategies In Paediatric Populationsmentioning

confidence: 99%

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Savvateeva

Erdes

Antishin

et al. 2018

Int Arch Allergy Immunol

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“…Autoimmune thyroiditis is the most prevalent coexisting autoimmune disorder in patients with celiac disease [9]. A pooled analysis, including 6024 patients with autoimmune thyroiditis, found a markedly increased prevalence of biopsy-confirmed coeliac disease, allowing the authors to conclude that all patients with autoimmune thyroiditis should be screened for the presence of coeliac disease [10]. The association between autoimmune thyroid disease and coeliac disease may be explained by low selenium [11] or vitamin D [12] status secondary to their malabsorption, the interaction of tissue transglutaminase-2 IgA antibodies to thyroid follicles and thyroid extracellular matrix [13], or by a shared immunogenetic make-up [14].…”

Section: Article Thiemementioning

confidence: 99%

The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto’s Thyroiditis: A Pilot Study

Krysiak

Szkróbka

Okopień

2018

Exp Clin Endocrinol Diabetes

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“…Although the prevalence of CD in those diseases varied substantially among studies, a systematic review with meta-analysis showed that 6 % of patients with type 1 diabetes have biopsy-confirmed celiac disease [ 11 ]. In autoimmune thyroid disease, a pooled analysis with 6024 patients found a prevalence of biopsy-verified CD of 1.6 %, and the prevalence of CD was higher in children with autoimmune thyroid disease [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of celiac disease in patients with Down syndrome: a meta-analysis

Shan

Cao

et al. 2017

Oncotarget

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BackgroundThe association between Down syndrome and celiac disease has been reported by many studies. However, the prevalence of celiac disease (CD) in Down syndrome (DS) varies considerably across studies (from 0 % to 19 %). The aim of this study was to use meta-analysis to exam the prevalence of CD in patients with DS.MethodsA systematic search of English articles from Pubmed, Web of Science and CNKI without year limitation. Data were extracted by two independent observers and pooled using a random effects model by the Comprehensive Meta-Analysis Version 2 software.ResultsA pooled analysis, based on 31 studies included 4383 individuals, revealed prevalence of biopsy-confirmed CD of 5.8 % (95 % CI = 4.7-7.2 %) in patients with DS. Sub-group analysis showed a slightly higher prevalence of CD in children with DS (6.6 %; 17 studies), than in age mixed samples with both children and adults (5.1 %; 13 studies). In addition, most of the studies included in this meta-analysis were from Europe and America, with the prevalence of celiac disease of 6 % (21 studies) and 5.7 % (6 studies) in DS patients, respectively. Furthermore, meta-regression analysis suggested that proportion of antibody-positive individuals that underwent small intestine biopsy had moderating effect on the outcome of the meta-analysis.ConclusionsThese results demonstrated that patients (children) with Down syndrome had high prevalence of CD (more than one in twenty). The prevalence is high enough to motivate screening CD in DS children.

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Prevalence of Celiac Disease in Patients with Autoimmune Thyroid Disease: A Meta-Analysis

Abstract: About 1/62 patients with ATD have biopsy-verified CD. It is argued that patients with ATD should be screened for CD, given this increased prevalence.

Cited by 74 publications

References 74 publications

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto’s Thyroiditis: A Pilot Study

Prevalence of celiac disease in patients with Down syndrome: a meta-analysis

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