Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants

Osborne, Nicholas J.; Koplin, Jennifer J.; Martin, Pamela E.; Gurrin, Lyle C.; Lowe, Adrian J.; Matheson, Melanie C.; Ponsonby, Anne–Louise; Wake, Melissa; Tang, Mimi L.K.; Dharmage, Shyamali C.; Allen, Katrina J.

doi:10.1016/j.jaci.2011.01.039

Cited by 893 publications

(703 citation statements)

References 21 publications

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“…IgE-mediated food allergies appear to be increasing 1 at a rate more rapid than changes to genome sequence would allow in isolation. 2 Such conditions are thought to arise through complex, but still poorly understood, gene-environment interactions during critical periods of immune development.…”

Section: Introductionmentioning

confidence: 99%

Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy

et al. 2014

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“…However, there is no evidence that delaying intro of solids including allergenic food after 4-6 months is protective. 28 In contrast, Australia, which appears to have one of the highest rates of food allergy in the world 29 is plagued by a plethora of infant feeding guidelines including Australian government guidelines which are essentially WHO compliant but recommend avoiding nuts till 3 years and maternal nut avoidance during pregnancy in the context of a strong family history of nut allergy, a raft of State-based guidelines which are all variations on a theme and the peak allergy specialty body guidelines which until recently were modelled on AAP guidelines although not as extreme with egg introduction recommended at after age 12 months rather than 2 years. 30 …”

Section: Weaning and Allergiesmentioning

confidence: 99%

Weaning and complementary feeding in preterm infants: management, timing and health outcome

Barachetti¹,

Villa²,

Barbarini³

2017

Pediatr Med Chir

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The introduction of solid food is necessary for any infant in order to provide adequate nutrition because when they grow up milk is insufficient for their nutritional needs. Infants born preterm have increased nutritional requirements. The high nutrient demands as well as the organ immaturity of preterm infants combine to render it difficult to achieve dietary intakes that will allow preterm infants to match their in utero growth rates. Current guidelines for the introduction of solid food to term infants cannot be directly translated to preterm infants. For preterm infants such guidelines are lacking. Based on the limited available evidence, it could be concluded that a corrected age of 3 months (13 weeks) may be an appropriate age to start introducing solid food for most preterm infants. About celiac disease (CD), gluten may be introduced into the infant’s diet anytime between 4 and 12 completed months of age. In children at high risk for CD, earlier introduction of gluten (4 vs 6 months or 6 vs 12 months) is associated with earlier development of CD autoimmunity (defined as positive serology) and CD, but the cumulative incidence of each in later childhood is similar. Relatively to weaning and allergies, the European Society of Pediatric Allergy and Clinical Immunology and the European Society for Paediatric Gastroenterology Hepatology and Nutrition have produced joint guidelines. They recommend exclusive breastfeeding for 4–6 months or use of hypoallergenic formulas if exclusive breastfeeding is not possible. In addition, The American Academy of Pediatrics recommendations now state that there is no evidence to recommend maternal dietary restrictions during pregnancy or breastfeeding. However, there is no evidence that delaying introduction of solids including allergenic foods after 4–6 months is protective.

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“…2). Sesame is a major cause of food allergy in some countries (Dalal et al 2002;Osborne et al 2011) and may be increasingly common in the US (Zuidmeer et al 2008). Stutius et al (2010) found that only 9 out of 69 patients with peanut allergies were also sensitive to sesame (Table 5).…”

Section: Pistachios and Cashewsmentioning

confidence: 99%

An Evolutionary Perspective on Human Cross-sensitivity to Tree Nut and Seed Allergens

Fisher¹,

Nawrocki²

2015

aliso

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Tree nut allergies are some of the most common and serious allergies in the United States. Patients who are sensitive to nuts or to seeds commonly called nuts are advised to avoid consuming a variety of different species, even though these may be distantly related in terms of their evolutionary history. This is because studies in the literature report that patients often display sensitivity to multiple nut species (crosssensitivity) if they have an existing nut allergy. These reports suggest that cross-sensitivity in patients with nut allergies may be caused by an IgE antibody reacting with epitopes present in the seed proteins of different species (cross-reactivity), for example, if IgE isolated from the serum of a patient were able to bind to both almond and peanut allergens. We hypothesize that allergenic proteins in seeds may have similar amino acid sequences that cause the observed cross-sensitivity. Here, we test the hypothesis that similarity in the protein sequences of allergenic nuts drives cross-sensitivity and cross-reactivity by reconstructing the gene trees of three allergenic seed-storage proteins (vicilin, legumin, and 2S albumin) from species sampled across vascular plants. We generate estimates of their phylogenetic relationships and compare these to the allergen cross-sensitivity and cross-reactivity data that is reported in the literature. In general, evolutionary relationships of the three proteins are congruent with the current understanding of plant species relationships. However, we find little evidence that distantly related nut species reported to be crossreactive share similar vicilin, legumin, or 2S albumin amino acid sequences. Our data thus suggests that features of the proteins other than their amino acid sequences may be driving the cross-reactivity observed during in vitro tests and skin tests. Our results support current treatment guidelines to limit nut and seed consumption if allergies are present in a patient. More studies are necessary to better understand the characteristics of allergenic proteins and patterns of cross-sensitivity in patients who suffer from nut allergies.

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Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants

Cited by 893 publications

References 21 publications

Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy

Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy

Weaning and complementary feeding in preterm infants: management, timing and health outcome

An Evolutionary Perspective on Human Cross-sensitivity to Tree Nut and Seed Allergens

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