Prevalence of Chlamydia trachomatis, Ureaplasma spp., Mycoplasma genitalium and Mycoplasma hominis among outpatients in central Greece: absence of tetracycline resistance gene tet(M) over a 4-year period study

Ikonomidis, Alexandros; Venetis, C.; Georgantzis, D.; Giaslakiotis, V.; Kolovos, V.; Efstathiou, K.; Moschou, M.; Koutsiaris, E.; Panopoulou, Maria

doi:10.1016/j.nmni.2015.11.005

Cited by 21 publications

(20 citation statements)

References 17 publications

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“…In our study, no association with other STIs was found in MG infection using the Chi-square test analysis, consistent with previous findings from UK [33,42] and Greece [33,42], showing that MG might be an independent pathogen in the genital tract. The high level of MG and CT/NG co-infection suggests that screening and treating CT may not have too much impact on MG since azithromycin 1 g which is the first-line drug in treating CT appears to be a suboptimal choice in MG treatment.…”

Section: Discussionsupporting

confidence: 92%

Prevalence and Correlates of Mycoplasma genitalium Infections among Patients Attending a Sexually Transmitted Infection Clinic in Guangdong, China a Cross-sectional Study

Zhang

Zhao

et al. 2020

Preprint

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Background Mycoplasma genitalium (MG) is known to cause urogenital tract infections and is associated with reproductive morbidity. Although MG has been reported across many regions and population groups, it is not yet routinely tested for in China. Our study contributes to current research by reporting the prevalence and correlates of MG for patients attending a sexually transmitted infection (STI) clinic in Guangdong from Jan 2017-May 2018.Methods Urethral (489 men) and endo-cervical (189 women) samples, blood samples, and patient histories (via questionnaires) were collected. Doctors clinically diagnosed anogenital warts (GW) during the examination (n=678). Presence of MG was tested using an in-house polymerase chain reaction. We also tested all participants for herpes simplex virus-2 (HSV-2), Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT), syphilis and HIV. Univariate and multivariable logistic regressions were used to evaluate factors associated with MG.Results MG was detected among 7.2% (n=49) of patients (7.4% men, 6.9% women). Of 629 heterosexual patients, the MG was detected in 7.5% (47/629), and of 49 MSM, MG was detected in 4.1% (2/49). Among MG-infected patients, 10.2% were co-infected with CT, 6.1% with NG, 8.2% with HSV-2, 4.1% with syphilis and 22.4% with GW. Among 152 symptomatic patients, the prevalence of MG was 12.5% (n=19, of whom 17 were men). Being symptomatic was statistically significant for MG infection [OR=2.2(1.3~3.8)].Conclusion MG is a relatively common infection among individuals attending an STI clinic in Guangdong province. To make MG testing available and routinely screen symptomatic patients with urinary and /or cervical discharge in STI clinics in China is essential.

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Section: Discussionsupporting

confidence: 92%

Prevalence and Correlates of Mycoplasma genitalium Infections among Patients Attending a Sexually Transmitted Infection Clinic in Guangdong, China a Cross-sectional Study

Zhang

Zhao

et al. 2020

Preprint

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“…Consistent with previous ndings from the UK [28] and Greece [34], no association of MG infection with other STIs was found in our study via the chi-square test, indicating that MG might be an independent pathogen in the genital tract. The high level of MG and CT/NG co-infection suggests that screening and treating CT may not greatly impact MG infection, since azithromycin (1 g), the rst-line drug for treating CT infection, appears to be a suboptimal choice for MG treatment.…”

Section: Correlates Of Mg Infectionssupporting

confidence: 92%

Prevalence and Correlates of Mycoplasma genitalium Infections among Patients Attending a Sexually Transmitted Infection Clinic in Guangdong, China a Cross-sectional Study

Zhang

Zhao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Mycoplasma genitalium (MG) causes urogenital tract infections and is associated with reproductive morbidity. Although MG has been reported across many regions and population groups, it is not yet routinely tested for in China. Our study contributes to current research by reporting the prevalence and correlates of MG infection in patients attending a sexually transmitted infection (STI) clinic in Guangdong from Jan 2017-May 2018.Methods: Urethral (from 489 men) and endo-cervical (from 189 women) samples, blood samples, and patient histories (via questionnaires) were collected. Doctors clinically diagnosed anogenital warts (GW) during the examination (n=678). The presence of MG was evaluated using an in-house via polymerase chain reaction protocol. We also tested all participants for herpes simplex virus-2 (HSV-2), Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT), syphilis and HIV. Univariate and multivariate logistic regression were used to evaluate factors associated with MG.Results: MG was detected in 7.2% (49/678) of the patients (men, 7.4%; women, 6.9%). The MG positivity rate was 14.2% among symptomatic patients, and 5.6% for asymptomatic patients , respectively. Only 36.7% (18/49) Mg positive patients were symptomatic. Among the MG-infected patients, 10.2% were co-infected with CT, 6.1% with NG, 8.2% with HSV-2, 4.1% with syphilis and 22.4% with GW. Presentation with clinical symptoms was significantly associated with MG infection [OR=2.52 (2.03-3.13)]. In our analysis, MG was not associated with other STIs.Conclusions: MG is a relatively common infection among individuals attending an STI clinic in Guangdong Province. Routine testing of symptomatic patients may be necessary, and more epidemiological studies are needed to provide evidence for future testing guidelines,

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“…A recent study from central Greece has reported absence of MG infection among individuals referred and investigated specifically for infertility problems. 23 However, other studies from Europe, Australia, New Zealand, USA, Asia and Africa have revealed a greater prevalence among STD clinic attendees, whether symptomatic or asymptomatic, in the range of 8.1% to >50%. 24 In the present study, MG as mono-infection was detected in three symptomatic males, all with microscopic findings of urethritis.…”

Section: Discussionmentioning

confidence: 95%

Prevalence of Mycoplasma genitalium and other sexually-transmitted pathogens among high-risk individuals in Greece

Chra

Papaparaskevas

Papadogeorgaki

et al. 2018

Germs

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Prevalence of Chlamydia trachomatis, Ureaplasma spp., Mycoplasma genitalium and Mycoplasma hominis among outpatients in central Greece: absence of tetracycline resistance gene tet(M) over a 4-year period study

Cited by 21 publications

References 17 publications

Prevalence and Correlates of Mycoplasma genitalium Infections among Patients Attending a Sexually Transmitted Infection Clinic in Guangdong, China a Cross-sectional Study

Prevalence and Correlates of Mycoplasma genitalium Infections among Patients Attending a Sexually Transmitted Infection Clinic in Guangdong, China a Cross-sectional Study

Prevalence and Correlates of Mycoplasma genitalium Infections among Patients Attending a Sexually Transmitted Infection Clinic in Guangdong, China a Cross-sectional Study

Prevalence of Mycoplasma genitalium and other sexually-transmitted pathogens among high-risk individuals in Greece

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