Prevalence of Cholelithiasis in Patients with Type 2 Diabetes and Obesity in a Basic Family Health Centre in Irec&amp;#234;, Northeastern Brazil

Guimarães, Sarah Virgínia Dantas; Gomes, Heldernilson Lopes Eugênio; Oliveira, Claudio Galindo de; Chiacchio, M.; Souza, Fabricio Miranda; Oliveira, Daniel Souza; Cerqueira, Renata Lima de; Dantas, Jurandir José Cerqueira; Rocha, Denise Rosso Tenório Wanderley; Arbex, Alberto Krayyem

doi:10.4236/ojemd.2016.61006

Cited by 2 publications

(3 citation statements)

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“…Studies in Brazil showed the prevalence of cholelithiasis 37.0% out of 70 patients with type 2 DM. Prevalence of gallstone disease is higher in diabetic individuals, with a prevalence of 21.0% in the diabetic group compared to 9.0% in the non-diabetic group [10]. Meanwhile study conducted in India found that 17.7% of patients with DM had gallstone detected by ultrasound [11].…”

Section: Introductionmentioning

confidence: 99%

“…Firstly, increased synthesis of total cholesterol in the body, promoting cholesterol stone formation. Secondly, diabetic patients also often have larger gallbladders with reduced motility, leading to increased cholesterol crystal formation [10,11]. Studies in Brazil showed the prevalence of cholelithiasis 37.0% out of 70 patients with type 2 DM.…”

Section: Introductionmentioning

confidence: 99%

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Obesity, dyslipidemia, and diabetes mellitus as risk factors in cholelithiasis

Hendarto,

Akbar,

Muzakki

et al. 2023

ELECTRON J GEN MED

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Objectives: Cholelithiasis or gallstones has many risk factors, such as age, sex, obesity, dyslipidemia, and diabetes mellitus (DM). Studies in developing country shown that obesity, dyslipidemia, and DM occurred in 55.0%, 76.0%, and 17.7% of adults with cholelithiasis, respectively. The aim of this study is to know the proportion of cholelithiasis risk factors. Materials & methods: This retrospective study using descriptive cross sectional design performed in one of the largest referral hospital in Jakarta Indonesia. Demographic data, and laboratory examination were collected from medical record. Patients presented with cholelithiasis from the abdominal ultrasonography was enrolled into study. Results: 93 subjects were selected through consecutive sampling, where in 65.8% were female and 77.5% age>40 years. The majority was obese (47.3%) and the obesity grade I was most prevalent. Dyslipidemia was found in 19.3% subjects with proportion of high total cholesterol was 54.5%, high LDL 90.9%, high triglycerides 27.3%, and low HDL 18.2%. DM was found in 15.0% subjects. Random blood glucose had higher proportion, accounting 57.2% with mean 140.67± 89.69 mg/dl. Female and age>40 years had more proportion in cholelithiasis patients. Conclusions: Proportion of cholelithiasis with obesity 47.3%, dyslipidemia 19.3%, and diabetes 15.0%. However, the proportion of obesity, dyslipidemia and diabetes in this study was lower than other studies in Asia or developing countries. Patients with obesity grade I, high LDL and RBG>40 mg/dl should be aware to have cholelithiasis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obesity, dyslipidemia, and diabetes mellitus as risk factors in cholelithiasis

Hendarto,

Akbar,

Muzakki

et al. 2023

ELECTRON J GEN MED

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“…Gallstone disease (GD) constitutes a significant health problem in developed societies, affecting 10% to 15% of the adult population [ 1 ]. It is estimated that 7% to 10% of the world’s population has either symptomatic or asymptomatic cholelithiasis [ 2 ]. The prevalence of diabetes mellitus in Pakistan is estimated to be around 11.77% [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Non-insulin-dependent Diabetes Mellitus Among Patients with Cholelithiasis: A Single-centered, Cross-sectional Study

Ali

Ahamad

Talpur

et al. 2018

Cureus

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IntroductionGallstone disease (GD) is one of the major causes of morbidity and mortality in the west and most of the countries worldwide. Cholelithiasis and diseases of the biliary tract are becoming more prevalent with the socioeconomic burden in developing countries like Pakistan. GD is a chronic, recurrent hepatobiliary disease, the basis of which is the impaired metabolism of cholesterol, bilirubin, and bile acids, which is characterized by the formation of gallstones in the hepatic bile duct, common bile duct, or gallbladder. Epidemiologic studies have shown that individuals with diabetes have a higher risk of cholelithiasis but only a few studies have been done in Pakistan to establish the association so far. Hence, the aim of the present study is to establish the association between diabetes and gallstone disease.MethodsA cross-sectional study was conducted at Liaquat University Civil Hospital, Hyderabad, Pakistan, between February 2017 and August 2017. Patients between the ages of 10 and 70 from either sex, who were diagnosed with cholelithiasis were included in this study whereas those patients who underwent cholecystectomy previously were excluded. Diabetic cases were identified based on fasting glucose levels (FGL) and the serum levels of HbA1c. An interview-based questionnaire was employed to collect the patient's demographic profile and risk factors by the students. Informed consent was taken from all the study subjects and the confidentiality of the data was ensured.ResultsFrom the sample size of patients evaluated (a total of 204), based on investigative studies performed, 74 cholelithiatic patients (36.6%) were found to concurrently have diabetes as well. Among the 74 patients with both cholelithiasis and diabetes type-2 (NIDDM), 56 were female and 18 were males. The rest of the patients with cholelithiasis were found to be non-diabetic (78 were males and 52 female). The majority of the GD patients (51 (25 males and 26 females)) in the study sample was in the 50-60 age group. The mean age of the patients was 43 ± 12.1. In this study, we measured the fasting glucose levels (FGL). According to World Health Organization (WHO) and American Diabetes Association (ADA) criteria, we categorized 85 of the GD patients to be non-diabetic with serum fasting glucose levels between 70 and 100 gm/dL, and 45 patients were categorized to be in the pre-diabetic group with FGL levels between 100 and 126. Out of the 204 samples with GD, we found that 74 patients have diabetes, with serum FGL >126mg/dL. We measured HbA1c from each individual in the study sample. It was found that 79 patients had HbA1c levels <5.5, they are categorised as non-diabetic according to WHO and ADA criteria, 51 patients had values between 5.5 and 6.5 (pre-diabetic), and 35 GD patients had HbA1c values between 6.5 and 7.5 (categorized as diabetics with good control) and 39 patients with HbA1c above 7.5 (diabetes with poor control).ConclusionIn this study, we concluded that there is a higher prevalence of NIDDM in GD patients and there is an a...

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Prevalence of Cholelithiasis in Patients with Type 2 Diabetes and Obesity in a Basic Family Health Centre in Irecê, Northeastern Brazil

Cited by 2 publications

References 18 publications

Obesity, dyslipidemia, and diabetes mellitus as risk factors in cholelithiasis

Obesity, dyslipidemia, and diabetes mellitus as risk factors in cholelithiasis

Prevalence of Non-insulin-dependent Diabetes Mellitus Among Patients with Cholelithiasis: A Single-centered, Cross-sectional Study

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