Prevalence of Chronic Diabetic Complications in Newly Diagnosed versus Known Type 2 Diabetic Subjects in a Sample of Alexandria Population, Egypt

Khalil, Sarah; Megallaa, Magdy Helmy; Rohoma, Kamel Hemida; Guindy, Myriam AbouSeif; Zaki, Adel; Hassanein, Mohamed; Malaty, Amin; Ismael, Hanaa; Kharboush, Ibrahim; Kafash, Dalal Nasr-Eldein El; Sallam, Hassan; Desouky, Iman Abdelkareem

doi:10.2174/1573399814666180125100917

Cited by 31 publications

(60 citation statements)

References 43 publications

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“…It should be noted that undiagnosed T2DM is a major problem, and the exact duration of T2DM is often unknown [50]. In a considerable number of patients, vascular complications are detected at the same time as the diagnosis of T2DM [51,52]. The finding that the odds of vascular and microvascular complications were higher in patients on lifestyle modification + OAD + insulin as part of their T2DM therapeutic regimen is consistent with previous research [53].…”

Section: Discussionsupporting

confidence: 85%

Prevalence and associated factors of vascular complications among inpatients with type 2 diabetes: A retrospective database study at a tertiary care department, Ningbo, China

Chattopadhyay

et al. 2020

PLoS ONE

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To determine the prevalence of vascular complications among inpatients with type 2 diabetes mellitus (T2DM) and factors independently associated with vascular complications in a tertiary care department in Ningbo, China, the authors conducted a cross-sectional study using an existing computerised medical records database. A total of 3370 adult patients with T2DM were admitted to this tertiary care department for the first time between 2012 and 2017. Patients were categorised as those (1) with at least one vascular complication, (2) with at least one microvascular complication, and (3) with at least one macrovascular complication. Over 5 years, the prevalence of vascular, microvascular, and macrovascular complications among inpatients with T2DM was 73.2%, 57.5%, and 51.4%, respectively. The odds of vascular, microvascular, and macrovascular complications increased with age and were higher in patients with hypertension. The odds of vascular and microvascular complications were higher in single, divorced, or widowed patients, patients with T2DM for a long time, and patients on advanced T2DM therapeutic regimen. The odds of vascular and macrovascular complications were lower in women. The odds of microvascular complications decreased with education. The odds of macrovascular complications were higher in smokers. In conclusion, in the tertiary care department, more than half of inpatients with T2DM had vascular complications, and factors independently associated with vascular complications were identified. The study findings could be used in future interventional studies to prevent and manage vascular complications among these patients.

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Section: Discussionsupporting

confidence: 85%

Prevalence and associated factors of vascular complications among inpatients with type 2 diabetes: A retrospective database study at a tertiary care department, Ningbo, China

Chattopadhyay

et al. 2020

PLoS ONE

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“…3 Patients with newly diagnosed diabetes in Alexandria, Egypt, already had evidence of diabetes complications, for example, neuropathy (3%), and nephropathy, retinopathy and peripheral artery disease (10% for each); the prevalence of these complications was 29%-48% for patients with known diabetes. 101 Complications (nephropathy and peripheral neuropathy) were also prevalent in the UAE for people with type 2 diabetes (44% and 37%, respectively) and prediabetes (29% and 13%, respectively); 73% of type 2 diabetes patients had retinopathy here (not investigated in prediabetes). 7 Importantly, complications of diabetes are already evident is some people with prediabetes.…”

Section: Discussionmentioning

confidence: 90%

Prediabetes management in the Middle East, Africa and Russia: Current status and call for action

Khalil

Abdelaziz

Shammary

et al. 2019

Diabetes and Vascular Disease Research

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Most data on the burden of diabetes and prediabetes are from countries where local infrastructure can support reliable estimates of the burden of non-communicable diseases. Countries in the Middle East and Africa, together with Russia, have a total population of almost 2 billion, but have been relatively overlooked by authors in this field. We reviewed the prevalence and drivers of prediabetes and diabetes across this large region. A large, and variable, burden of dysglycaemia exists, especially in Middle Eastern and North African countries, associated with high levels of obesity and sedentariness, with a generally lower prevalence in most other parts of Africa. The design and size of studies are highly variable, and more research to quantify the scale of the problem is needed. Local barriers to care relating to issues concerned with gender, consanguinity, lack of understanding of diabetes, lack of understanding of obesity as a health issue, and limited resource at a national level for tracking and intervention for diabetes and other non-communicable diseases. Lifestyle interventions with proven local cost-effectiveness, enhanced access to pharmacologic intervention, and societal interventions to promote better diet and more activity will be an important element in strategies to combat these adverse trends.

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“…Totally, 1,278 studies were retrieved, of which, 1,261 studies were found from six international databases and the remaining 17 were through manual search. Databases includes; PubMed 161 [44,45], 2 research paper from Egypt [46,47],the remaining was from Ghana [15],Uganda [48],and Tanzania [49]. The highest prevalence of diabetic peripheral neuropathy (83.4%) and the lowest (7.5%) were reported from Nigeria.…”

Section: Search Resultsmentioning

confidence: 99%

Prevalence of diabetic peripheral neuropathy in Africa: A systematic review and meta-analysis

Shiferaw

Akalu

Work

et al. 2019

Preprint

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Introduction: Diabetes mellitus is a global health care problem and financially costly. Diabetic peripheral neuropathy is common and frequent cause of morbidity and disability. Despite its serious complications,limited evidence is available on the magnitude of diabetic peripheral neuropathy among patient with diabetes mellitus. Hence the objective of this systematic review and meta-analysis was to estimate the pooled prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Africa. Methods: PubMed Scopus Google Scholar Africa journal online WHO afro library and Cochrane review were systematically searched online to retrieve related articles. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline was followed. Heterogeneity across the included studies was evaluated by inconsistency index (I2). Publication bias was examined by funnel plot and Egger regression test. The random-effect model was fitted to estimate the pooled prevalence of diabetic peripheral neuropathy among diabetes mellitus patients. All statistical analysis was done using STATA version 14 software for windows. Results: Twenty-three studies which comprises of 269 691 participants were included in the meta-analysis. The overall pooled prevalence of diabetic peripheral neuropathy was 46% (95% CI:36.21-55.78%). Based on the subgroup analysis the highest magnitude of diabetic peripheral neuropathy was reported in West Africa 49.4% (95% CI: 32.74, 66.06). Conclusion: This study revealed that the overall prevalence of diabetic peripheral neuropathy is relatively high in Africa. Hence, diabetic peripheral neuropathy needs situation based intervention and preventive strategy depending on their country context. Furthermore further meta-analysis study is needed to identify associated factors for the occurrence of diabetic peripheral neuropathy. Key word: diabetic peripheral neuropathy diabetes mellitus Systematic review Meta-analysis Ethiopia.

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Prevalence of Chronic Diabetic Complications in Newly Diagnosed versus Known Type 2 Diabetic Subjects in a Sample of Alexandria Population, Egypt

Cited by 31 publications

References 43 publications

Prevalence and associated factors of vascular complications among inpatients with type 2 diabetes: A retrospective database study at a tertiary care department, Ningbo, China

Prevalence and associated factors of vascular complications among inpatients with type 2 diabetes: A retrospective database study at a tertiary care department, Ningbo, China

Prediabetes management in the Middle East, Africa and Russia: Current status and call for action

Prevalence of diabetic peripheral neuropathy in Africa: A systematic review and meta-analysis

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