Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis

Leroi, Charline; Adam, Pierrick; Khamduang, Woottichai; Kawilapat, Suttipong; Ngo‐Giang‐Huong, Nicole; Ongwandee, Sumet; Jiamsiri, Suchada; Jourdain, Gonzague

doi:10.1016/j.ijid.2016.08.017

Cited by 51 publications

(47 citation statements)

References 38 publications

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“…In this review, though the overall pooled prevalence estimate (6%) showed a slight decrement compared to the previous estimation (7.4%) [91], it is still a burden that represents an additional challenge for the national health system which is already fighting with the different infectious and noninfectious disease. In comparison to other studies conducted elsewhere, the result was more or less comparable to a finding from Thailand 5.1% [92]. However, it was significantly exceeded the global estimation (3.61%) and a finding from Though the pooled prevalence (4%) of HBV among blood donors was significantly decreased compared to the previous estimate 8.4% [91], our study raised concerns on strict adherence of safe blood supply in Ethiopia as 1 in 25 (4%) blood donors might be infected with the virus.…”

Section: Discussionsupporting

confidence: 82%

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Yazie

Girma

2019

Preprint

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Background Hepatitis B virus is one of the major public health concerns globally. It is highly infectious and can be transmitted from one person to the other through vertically or horizontally via contaminated body fluid exposure. Despite the provision of an effective vaccine, it remains a major problem worldwide, particularly in developing countries. Methods Online electronic databases including PubMed, Google Scholar, Science Direct, African Index Medicus, African Journals Online, and WHO Afro Library were searched and published articles from 2010 to June 8, 2019, were considered. Two authors independently screened articles and extracted data. Funnel-Plots and Egger’s test statistics were used to determine the presence of small study effects and publication bias. The pooled prevalence of HBV was analyzed using a random effects model. The possible sources of heterogeneity was analyzed through subgroup analysis, sensitivity analysis, and meta-regression. Results The overall pooled prevalence of HBV was 6% and among subgroups pregnant women, healthcare workers, and HIV positive patients accounted for 5% for each group. Relatively low prevalence (4%) was obtained among blood donors. The Egger’s test statistics (p=0.747) indicated the absence of publication bias. In addition, from the sensitivity analysis, there was no influence on the overall effect while removing a single study at a time. The level of heterogeneity was reduced among pregnant women, HIV positive and studies with unknown sampling techniques. After conducting meta-regression, province, study group, screening method, and quality of papers were identified as sources of heterogeneity. Conclusions The overall pooled prevalence of HBV in Ethiopia was high. Strengthening and scaling up of the scope of the existing vaccination program and implementing novel approaches including screen-and-treat could be implemented to reduce the burden of the disease. Generally, the study can provide current prevalence estimate of HBV that could vital for intervention to tackle the disease.

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Section: Discussionsupporting

confidence: 82%

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Yazie

Girma

2019

Preprint

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“…Estos resultados, particularmente en el caso de los jóvenes, pueden tener relación con la incorporación de la vacuna contra la hepatitis B como parte del programa de inmunización en la década de los 90. La vacuna contra la hepatitis B se ha traducido en reducción importante en la prevalencia de HBsAg (19) ; sin embargo, el efecto no sería muy favorable en escenarios donde la cobertura de la vacuna contra HVB es deficiente (20) .…”

Section: Discussionunclassified

Marcadores de infección para hepatitis viral en donantes de sangre de un hospital nacional de Lima metropolitana

Morales

Fuentes-Rivera

Delgado-Silva

et al. 2017

Rev Peru Med Exp Salud Publica

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RESUMENEl objetivo del estudio fue determinar la frecuencia de marcadores de infección para hepatitis B, hepatitis C y conocer los factores asociados en los donantes de sangre. El estudio se realizó con datos del registro de donantes de un hospital público de Lima. De 28 263 sujetos analizados entre 2012 y 2015, el 0,6% (n=156) fue reactivo para HBsAg; 5,2% (n=1465) para anti-HBc, y 0,8% (n=232) para Anti-HVC. Los resultados positivos para HBsAg (p=0,319) y anti-HVC (p=0,037) fueron en mayor proporción en los donantes voluntarios. Los resultados positivos para HBsAg y anti-HBc fueron en mayor proporción en las personas de 50 a más años de edad. Los donantes voluntarios fueron en mayor proporción en los sujetos menores de 20 años (p<0,001). En conclusión, la reactividad a los marcadores de infección para hepatitis está asociado a la donación voluntaria y al grupo de edad de los donantes. Palabras clave: Hepatitis B; Hepatitis C; Donantes de sangre (Fuente: DeCS, BIREME). VIRAL HEPATITIS INFECTION MARKERS AMONG BLOOD DONOR IN A NATIONAL HOSPITAL OF METROPOLITAN LIMA ABSTRACTThe aim of the study was to determine the frequency of infection markers for hepatitis B and hepatitis C and to identify associated factors in blood donors. The study was carried out using data obtained from blood donor medical records collected in a public hospital in Lima. Of 28,263 individuals analyzed between 2012 and 2015, 0.6% (n=156) were reactive for HBsAg; 5.2% (n=1,465), for anti-HBc; and 0.8% (n=232), for anti-HVC. Positive results for HBsAg (p=0.319) and anti-HVC (p=0.037) were more common in voluntary donors. For HBsAg and anti-HBc, positive results were more common in individuals aged 50 years or older. The number of voluntary donors was higher among individuals younger than 20 years (p<0.001). The study indicates that reactivity to hepatitis infection markers is associated with voluntary donation and the age group of blood donors. Key words: Hepatitis B; Hepatitis C; Blood donors (Source: MeSH, NLM). INTRODUCCIÓNLa hepatitis viral, una pandemia silenciosa que genera una enorme carga para los sistemas de salud, es la octava causa de mortalidad en todo el mundo. Se estima que cada año ocasiona 1,4 millones de muertes por infección aguda, cáncer hepático y cirrosis relacionadas con la hepatitis, de los cuales el 55 % son atribuidos al virus de la hepatitis B (VHB) y el 35% al virus de la hepatitis C (VHC) (1) . A nivel mundial, se estima que 2000 millones de personas están afectadas por el VHB, de ellas, 240 millones padecen infección hepática crónica por el VHB y corren el riesgo de fallecer por cirrosis o carcinoma hepatocelular, enfermedades que, se calcula, provocan de 500 000 a 700 000 muertes por año en el mundo (2) .La prevalencia del VHB es variable según las regiones, se estima de 5 a 8% en África y de 2 a 4% en Sudamérica (2)

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“…These cases are most commonly caused by HBV infection (73.6%) [9]. The under-recognition of hepatitis B infection and poor adherence to surveillance program in those diagnosed with hepatitis B result in high prevalence rates [10,11].…”

Section: Chronic Hepatitis B Virus (Hbv) Infection Is Endemic Inmentioning

confidence: 99%

Family history of liver cancer may indicate chronic hepatitis B virus infection in an endemic area

Sukeepaisalncharoen¹,

Peansukwech²,

Sawanyawisuth³

et al. 2017

APJTD

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Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis

Abstract: The high burden of CHB in Asian countries is a major challenge for the incorporation of national programs to prevent CHB complications within health care systems.

Cited by 51 publications

References 38 publications

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Marcadores de infección para hepatitis viral en donantes de sangre de un hospital nacional de Lima metropolitana

Family history of liver cancer may indicate chronic hepatitis B virus infection in an endemic area

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