Prevalence of Chronic Kidney Disease in Iranian General Population: A Meta‐Analysis and Systematic Review

Bouya, Salehoddin; Balouchi, Abbas; Rafiemanesh, Hosein; Hesaraki, Mehran

doi:10.1111/1744-9987.12716

Cited by 66 publications

(54 citation statements)

References 33 publications

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“…CKD is a progressive condition that can lead to significant mortality and morbidity and is commonly asymptomatic in the early stages. Thus, the overall prevalence of the disease is likely to be higher than expected (5).…”

Section: Introductionmentioning

confidence: 92%

“…The overall prevalence of CKD in the Iranian general population is 15.1%, which is much higher than the average Copyright © 2020, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited global prevalence of CKD (5). CKD is a progressive condition that can lead to significant mortality and morbidity and is commonly asymptomatic in the early stages.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models

Mozafari

Mansournia

Sayehmiri

et al. 2020

Iran Red Crescent Med J

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Background: Lipid disorders are a well-documented risk factor for chronic kidney disease (CKD), but the impact of lipid abnormalities in the progression of the disease remains mixed. Objectives: The current study aimed to extend the existing knowledge about the effect of lipid disorders in disease progression from moderate to severe stage using Flexible parametric survival models. Methods: This retrospective cohort study included 308 moderate CKD patients who received the nephrologist follow-up visits at the nephrology clinic, Ilam (Iran), from 2012 to 2019. The survival time was determined based on the time medically diagnosed with moderate stages (GFR = 59 - 55 mL/min per 1.73 m2) to the time of progression to the severe stage (GFR = 29 - 25 mL/min per 1.73 m2) hazard using flexible parametric survival models. Results: In univariate analysis, high levels of TG, LDL, and cholesterol were important risk factors which affect the CKD progression. The hazard of patients with TG > 200 mg/dL was 1.69 times higher than patients with desirable TG levels (P = 0.09). Moreover, for patients with LDL > 160 mg/dL, the hazard was 2.12 times higher than patients with desirable LDL levels (P = 0.01). The hazard of patients with total cholesterol levels > 240 mg/dL was 2.10 times higher than patients with desirable cholesterol levels (P = 0.003). The adjusted model was shown to better fit the PH model. Cholesterol levels > 240 mg/dL remains a significant risk factor for CKD progression (P = 0.03). Conclusions: Effective treatment programs should pay closer attention to screening and treatment of hyperlipidemia in patients diagnosed with moderate CKD.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models

Mozafari

Mansournia

Sayehmiri

et al. 2020

Iran Red Crescent Med J

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“…It is an important cause of morbidity and mortality, and is rapidly becoming a major burden on the global health-care system. 1 The prevalence of CKD is estimated at about 15.14% in Iranian general population 2 There is a substantial interest in identifying the causes and risk factors of CKD to reduce its global burden.…”

Section: Introductionmentioning

confidence: 99%

<p>Prevalence and Risk Factors of Hyperuricemia in Patients with Chronic Kidney Disease and Non-Alcoholic Fatty Liver</p>

Golmohammadi¹,

Tavasoli²,

Asadi³

2020

CEG

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Background/Aims The number of patients with nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) is on the rise. Epidemiological studies have shown the role of hyperuricemia in the development of NAFLD and CKD through oxidative stress and inflammatory mediators. Therefore, this study was conducted to investigate the prevalence and risk factors of hyperuricemia in patients with CKD and NAFLD in Iran. Patients and Methods This study was conducted in 450 CKD patients. NAFLD was diagnosed by ultrasonography. According to the serum uric acid level, all CKD + NAFLD + patients were divided into non-hyperuricemia and hyperuricemia groups. The patients’ demographic and clinical data such as age, sex, abdominal obesity, metabolic syndrome, diabetes, hypertension, CRP, hepatic steatosis, blood pressure, serum uric acid (UA), lipid and creatinine were collected for analysis. Results A total of 279 cases (62%) were diagnosed with NAFLD. The prevalence rate of NFALD in CKD patients was significantly lower in normal UA level than hyperuricemia (42.7% vs 57.3%) (P=0.039). The prevalence of hyperuricemia was about 57.3% in patients with CKD and NAFLD. Accordingly, 279 CKD patients with NAFLD were enrolled and divided into hyperuricemia (n =160) and non-hyperuricemia groups (n =119). Patients with hyperuricemia showed higher creatinine and lipid levels, and a lower GFR compared to patients with normal uric acid levels (P< 0.05). However, no significant difference was observed in age, sex, abdominal obesity, metabolic syndrome, hypertension, type 2 diabetes, CRP, and steatosis between hyperuricemia and non-hyperuricemia groups (P>0.05). Three factors, including type 2 diabetes, hyperlipidemia, and a low GFR, serve as independent risk factors for hyperuricemia (P<0.05). Conclusion The results showed a high prevalence of hyperuricemia in patients with CKD and NAFLD. A more comprehensive strategic management is necessary to address the potential harmful effects of hyperuricemia on the health of CKD + NAFLD + cases.

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“…The incidence and prevalence of CKD are increasing rapidly worldwide, particularly in developing countries (2). The prevalence of CKD in Iran was estimated at 15.14% (3). In all developed and many developing countries, diabetes and hypertension appear to be major causes of CKD (1).…”

Section: Introductionmentioning

confidence: 99%

Dietary Patterns and Risk of Chronic Kidney Disease Among Tehranian Adults with High Blood Pressure

Naderinejad

Ejtahed

Asghari

et al. 2020

Int J Endocrinol Metab

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Background:Although high blood pressure is an important risk factor for chronic kidney disease (CKD), it remains unclear whether diet can still influence the risk of CKD in adults with high blood pressure. Objectives: This study aimed at investigating the association between major dietary patterns and the incidence of CKD in adults with high blood pressure. Methods:In this cross-sectional study, we recruited 1,521 subjects aged ≥ 27 years with high blood pressure and with preserved estimated glomerular filtration rate at baseline, who participated in the fourth examination survey of the Tehran Lipid and Glucose Study. The principal component analysis was performed to derive dietary patterns. High blood pressure was defined as systolic blood pressure ≥ 120, diastolic blood pressure ≥ 80, or the current use of antihypertensive drugs. Multiple logistic regression analysis was applied to investigate the association between the dietary pattern scores and CKD risk. Results: After 3.6 years of follow-up, the incidence of CKD was 16.8%. Three dietary patterns were produced by using factor analysis, including the Western, the healthy, and the traditional Iranian dietary patterns. The healthy and the traditional Iranian dietary patterns were not related to the risk of CKD, but scoring on the Western dietary pattern was associated with enhanced odds of CKD, after being adjusted for relevant confounders (odds ratio: 2.12; 95% confidence interval: 1.19 -3.76). Conclusions: Results of this study provided evidence that a high score on the Western dietary pattern was associated with an increased risk of CKD in adults with high blood pressure.

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Prevalence of Chronic Kidney Disease in Iranian General Population: A Meta‐Analysis and Systematic Review

Cited by 66 publications

References 33 publications

Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models

Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models

<p>Prevalence and Risk Factors of Hyperuricemia in Patients with Chronic Kidney Disease and Non-Alcoholic Fatty Liver</p>

Dietary Patterns and Risk of Chronic Kidney Disease Among Tehranian Adults with High Blood Pressure

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