Prevalence of Chronic Kidney Disease and Associated Risk Factors, and Risk of End-Stage Renal Disease: Data from the PREVADIAB Study

Vinhas, José; Gardete-Correia, L.; Boavida, J. M.; Raposo, João Filipe; Mesquita, Ana Cristina; Fona, Maria Conceição; Carvalho, Raquel; Cardoso, Salvador Massano

doi:10.1159/000324218

Cited by 44 publications

(45 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another national study [15], carried out between 2006 and 2007, with different selection criteria and including an older population (mean age of 58.1 years), observed crude MetS prevalence rates of 28.4%, 65.5% and 69.4%, respectively, discretely higher than those in the present study. The PREVADIAB study conducted from 2008 to 2009 showed a crude prevalence of 41.5% by IDF criteria [14]. Nevertheless, the national prevalence of MetS is higher than in some European countries and the USA [8].…”

Section: Discussionmentioning

confidence: 99%

The prevalence of the metabolic syndrome in Portugal: the PORMETS study

et al. 2017

View full text Add to dashboard Cite

BackgroundThe PORMETS study was designed to estimate the prevalence of metabolic syndrome and its determinants in the overall and administrative regions of the Portuguese mainland.MethodsA cross-sectional study of a representative sample of non-institutionalized Portuguese adults selected from primary health care centres lists including 1695 men and 2309 women was conducted from February 2007 to July 2009. A structured questionnaire was administered, collecting information on personal medical history and socio-demographic and behavioural characteristics. Anthropometrics, blood pressure, and venous blood samples were obtained. Metabolic syndrome was defined according to three operational definitions. The prevalence ratios and their respective 95% confidence intervals were calculated using binomial generalized linear regression, with the log link function.ResultsThe prevalence rates of metabolic syndrome in this sample of Portuguese adults were 36.5%, 49.6%, and 43.1%, using the Adult Treatment Panel III, International Diabetes Federation and Joint Interim Statement definitions, respectively. The most prevalent feature of metabolic syndrome in this sample was high blood pressure (64.3%) and the lowest was high fasting glucose (24.9%). After adjustment for age and gender, significant differences were observed for the 18 districts of the Portugal mainland. Additionally, metabolic syndrome was significantly more frequent in non-urban areas than in urban ones (p = 0.001). The prevalence of metabolic syndrome was significantly higher in women (p˂0.001) and older participants (p˂0.001), as well as in those who reported being housewives (p = 0.010), retired (p = 0.046) or unemployed (p = 0.024).ConclusionsThis study showed that metabolic syndrome is highly prevalent in the Portuguese adult population. Regional differences in the prevalence of this syndrome were observed, and this condition was more common in non-urban areas and less favoured socio-economic categories.

show abstract

Section: Discussionmentioning

confidence: 99%

The prevalence of the metabolic syndrome in Portugal: the PORMETS study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The number of patients with chronic kidney disease (CKD) is rising to epidemic proportions [1]. In 2008, the median prevalence of CKD was 7% in persons aged 30 years or older.…”

Section: Introductionmentioning

confidence: 99%

Human Embryonic Mesenchymal Stem Cell-Derived Conditioned Medium Rescues Kidney Function in Rats with Established Chronic Kidney Disease

et al. 2012

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is a major health care problem, affecting more than 35% of the elderly population worldwide. New interventions to slow or prevent disease progression are urgently needed. Beneficial effects of mesenchymal stem cells (MSC) have been described, however it is unclear whether the MSCs themselves or their secretome is required. We hypothesized that MSC-derived conditioned medium (CM) reduces progression of CKD and studied functional and structural effects in a rat model of established CKD.CKD was induced by 5/6 nephrectomy (SNX) combined with L-NNA and 6% NaCl diet in Lewis rats. Six weeks after SNX, CKD rats received either 50 µg CM or 50 µg non-CM (NCM) twice daily intravenously for four consecutive days. Six weeks after treatment CM administration was functionally effective: glomerular filtration rate (inulin clearance) and effective renal plasma flow (PAH clearance) were significantly higher in CM vs. NCM-treatment. Systolic blood pressure was lower in CM compared to NCM. Proteinuria tended to be lower after CM. Tubular and glomerular damage were reduced and more glomerular endothelial cells were found after CM. DNA damage repair was increased after CM. MSC-CM derived exosomes, tested in the same experimental setting, showed no protective effect on the kidney. In a rat model of established CKD, we demonstrated that administration of MSC-CM has a long-lasting therapeutic rescue function shown by decreased progression of CKD and reduced hypertension and glomerular injury.

show abstract

“…1,4 Although additional risks for the progression of CKD such as physical inactivity, smoking and obesity are underestimated in Jordanian patients, they are well appreciated in other populations. 2,3 Obesity is highly associated with release of lipolysis products into the systematic circulation in addition to the inflammatory mediators such as cytokines. 2 These mechanism may interfere with the engagement of the individual in a healthy lifestyles.…”

Section: Introductionmentioning

confidence: 99%