Prevalence of chronic obstructive pulmonary disease and associated risk factors in Uganda (FRESH AIR Uganda): a prospective cross-sectional observational study

Gemert, Frederik van; Kirenga, Bruce; Chavannes, Niels H.; Kamya, Moses R.; Luzige, Simon; Musinguzi, Patrick; Turyagaruka, John; Jones, Rupert; Tsiligianni, Ioanna; Williams, Siân; Jong, Corina de; Molen, Thys van der

doi:10.1016/s2214-109x(14)70337-7

Cited by 181 publications

(216 citation statements)

References 28 publications

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“…An increased amount of inhaled black carbon leads to an increased susceptibility for infections and decreased immunity 44 . Similarly, the use of biomass fuels within a house increases the risks of recurrent respiratory tract infections, poor lung growth, and the development of asthma and recently has been shown to have led to the development of chronic obstructive pulmonary disease in individuals as young as 35 years 45– 47 . The use of natural gas as a source of cooking fuel increases the levels of nitrogen dioxide in the household air and this has been associated with an increased prevalence of viral infections of the upper respiratory tract, more so in children 48 .…”

Section: Effects Of Household Air Pollutionmentioning

confidence: 99%

Household air pollution and its effects on health

Apte¹,

Salvi²

2016

F1000Res

138

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Household air pollution is a leading cause of disability-adjusted life years in Southeast Asia and the third leading cause of disability-adjusted life years globally. There are at least sixty sources of household air pollution, and these vary from country to country. Indoor tobacco smoking, construction material used in building houses, fuel used for cooking, heating and lighting, use of incense and various forms of mosquito repellents, use of pesticides and chemicals used for cleaning at home, and use of artificial fragrances are some of the various sources that contribute to household air pollution. Household air pollution affects all stages of life with multi-systemic health effects, and its effects are evident right from pre-conception to old age. In utero exposure to household air pollutants has been shown to have health effects which resonate over the entire lifetime. Exposures to indoor air pollutants in early childhood also tend to have repercussions throughout life. The respiratory system bears the maximum brunt, but effects on the cardiovascular system, endocrine system, and nervous system are largely underplayed. Household air pollutants have also been implicated in the development of various types of cancers. Identifying household air pollutants and their health implications helps us prepare for various health-related issues. However, the real challenge is adopting changes to reduce the health effects of household air pollution and designing innovative interventions to minimize the risk of further exposure. This review is an attempt to understand the various sources of household air pollution, the effects on health, and strategies to deal with this emergent risk factor of global mortality and morbidity.

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Section: Effects Of Household Air Pollutionmentioning

confidence: 99%

Household air pollution and its effects on health

Apte¹,

Salvi²

2016

F1000Res

138

View full text Add to dashboard Cite

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“…In many cases, asthma coexists with atopy and allergic rhinitis2 though many patients with atopy or allergic rhinitis never develop asthma. COPD, on the other hand, is driven by long-term exposure to cigarette smoke or biomass fuel, though increasingly the role of prior tuberculosis infection is being recognized as an important cofactor for COPD in tuberculosis endemic areas such as Korea and South Africa9101112. Aside from cigarette smoke and a prior history of tuberculosis, the other major risk factor for COPD is aging.…”

Section: Introductionmentioning

confidence: 99%

Asthma-COPD Overlap Syndrome: What We Know and What We Don't

Sin

2017

Tuberc Respir Dis

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Approximately one in four patients with chronic obstructive pulmonary disease (COPD) have asthmatic features consisting of wheezing, airway hyper-responsiveness or atopy. The Global initiative for Asthma/Globalinitiative for chronic Obstructive Lung Disease committee recently labelled these patients as having asthma-COPD overlap syndrome or ACOS. ACOS also encompasses patients with asthma, ≥40 years of age, who have been cigarette smokers (more than 5–10 pack years) or have had significant biomass exposure, and demonstrate persistent airflow limitation defined as a post-bronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity of <70%. Data over the past 30 years indicate that patients with ACOS have greater burden of symptoms including dyspnea and cough and show higher risk of COPD exacerbations and hospitalizations than those with pure COPD or pure asthma. Patients with ACOS also have increased risk of rapid FEV1 decline and COPD mortality. Paradoxically, experimental evidence to support therapeutic decisions in ACOS patients is lacking because traditionally, patients with ACOS have been systematically excluded from therapeutic COPD and asthma trials to maintain homogeneity of the study population. In this study, we summarize the current understanding of ACOS, focusing on definitions, epidemiology and patient prognosis.

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“…(Hosgood et al 2011; Reid et al 2012; Seow et al 2014; Bruce et al 2015; Josyula et al 2015). Annually, COPD and lung cancer cause approximately 650,000 premature deaths among women (Van Gemert et al 2015). Long-term exposure to PM 2.5 is strongly associated with mortality from cardiovascular disease compared to non-malignant respiratory disease (Hoek et al 2013).…”

Section: Introduction and Purposementioning

confidence: 99%

Biomass Cooking Fuels and Health Outcomes for Women in Malawi

2016

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In sub-Saharan Africa, biomass fuels account for approximately 90% of household energy consumption. Limited evidence exists on the association between different biomass fuels and health outcomes. We report results from a cross-sectional sample of 655 households in Malawi. We calculated odds ratios between hypothesized determinants of household air pollution (HAP) exposure (fuel, stove type, and cooking location) and five categories of health outcomes (cardiopulmonary, respiratory, neurologic, eye health, and burns). Reliance on high- or low-quality firewood or crop residue (vs. charcoal) was associated with significantly higher odds of shortness of breath, difficulty breathing, chest pains, night phlegm, forgetfulness, dizziness, and dry irritated eyes. Use of high-quality firewood was associated with significantly lower odds of persistent phlegm. Cooks in rural areas (vs. urban areas) had significantly higher odds of experiencing shortness of breath, persistent cough, and phlegm, but significantly lower odds of phlegm, forgetfulness, and burns. With deforestation and population pressures increasing reliance on low-quality biomass fuels, prevalence of HAP-related cardiopulmonary and neurologic symptoms will likely increase among cooks. Short- to medium-term strategies are needed to secure access to high-quality biomass fuels given limited potential for scalable transitions to modern energy.

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Prevalence of chronic obstructive pulmonary disease and associated risk factors in Uganda (FRESH AIR Uganda): a prospective cross-sectional observational study

Abstract: International Primary Care Respiratory Group.

Cited by 181 publications

References 28 publications

Household air pollution and its effects on health

Household air pollution and its effects on health

Asthma-COPD Overlap Syndrome: What We Know and What We Don't

Biomass Cooking Fuels and Health Outcomes for Women in Malawi

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