2019
DOI: 10.1001/jamaoncol.2019.1439
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Prevalence of Chronic Pain and High-Impact Chronic Pain in Cancer Survivors in the United States

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Cited by 97 publications
(62 citation statements)
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“…Moderate to severe pain (numerical rating scale score ≥ 5) was reported by 38.0% of all patients . This was confirmed in a very recent study of a representative sample of 4526 cancer survivors: 34.6% reported having chronic pain, and 16.1% reported having high‐impact cancer pain . When these data are translated to the whole US population, approximately 5.39 million persons have cancer‐associated pain, and 2.51 million cancer survivors have high‐impact cancer pain.…”
supporting
confidence: 58%
“…Moderate to severe pain (numerical rating scale score ≥ 5) was reported by 38.0% of all patients . This was confirmed in a very recent study of a representative sample of 4526 cancer survivors: 34.6% reported having chronic pain, and 16.1% reported having high‐impact cancer pain . When these data are translated to the whole US population, approximately 5.39 million persons have cancer‐associated pain, and 2.51 million cancer survivors have high‐impact cancer pain.…”
supporting
confidence: 58%
“…According to data reported in literature, pain is a symptom that affects 64% of patients with locally advanced or metastatic tumors, 59% in patients during their oncology treatment, and 33% of patients who have been cured from their pathologies, with over one third of these rating their pain as moderate or severe (van den Beuken-van Everdingen et al, 2007). This data, regarding prevalence of pain in patients surviving cancer, was recently confirmed in the North-American population and, in this latter study, the presence of pain was related to a lower education level, lack of healthcare insurance, and the fact that the former patient was unemployed, which, in the United States setting, is related to a less effective access to medical care (Jiang et al, 2019). In addition to this alarming prevalence, pain may bring important and severe consequences, which comprise a set of maladaptive responses in the physical, psychological, family, and social settings (Brennan et al, 2007), besides the evident impairment in the subject's quality of life (Cipta et al, 2015).…”
Section: Introductionmentioning
confidence: 57%
“… 63 , 64 Residual tissue damage caused by cancer and its treatments (chemotherapy, radiation, and surgery) elicits somatic musculoskeletal pain in patients by inciting inflammation and stimulating nociceptive receptors in the injured bone, muscle, ligaments, and joints. 2 , 4 , 6 Preclinical research investigating the mechanistic action of PRP suggests that it inhibits nociceptive response and reduces inflammation. 20 , 21 One in vivo study demonstrated that application of PRP for 5 hours led to lower blood flow velocity and less edema compared to control in ear pinna of rabbits with soft tissue injury.…”
Section: Discussionmentioning
confidence: 99%
“…19 It is estimated that 5.4 million cancer survivors are still living with poorly managed chronic pain despite increased pain control efforts. 2 This underscores the unmet needs of the oncologic community and the demand for integration of novel therapeutic approaches for pain management into comprehensive cancer care.…”
Section: Introductionmentioning
confidence: 99%