Prevalence of chronic pulmonary aspergillosis and the antifungal drug resistance of Aspergillusspp. in pulmonary tuberculosis patients in Uzbekistan

Toychiev, Abdurakhim; Belotserkovets, Vera; Ignat'ev, N. A.; Madrakhimov, Shavkat; Shaislamova, Mukambar; Osipova, Svetlana

doi:10.1177/00494755221110678

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…In Manaus, a cross-sectional study of 213 smear-negative ‘PTB’ patients found 15 with a pulmonary mycosis based on culture, serology, and CT scanning, of whom 10 (4.7%) had CPA ( Matsuda et al., 2021 ). In Uzbekistan, 12 (20%) of 60 smear-negative TB patients had CPA ( Toychiev et al., 2022 ).…”

Section: Methodsmentioning

confidence: 99%

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New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB – a revised burden for India

Denning

Cole²,

Goel³

2023

IJID Regions

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Section: Methodsmentioning

confidence: 99%

“…Likewise, in Iran, nine of 94 (10%) of patients had CPA during or immediately after ATT therapy ( Hedayati et al., 2015 ). In Uzbekistan, 16 (11.4%) of 140 patients with smear-positive TB had CPA ( Toychiev et al., 2022 ). The lack of precise timing of CPA relative to initiation of ATT prevented the use of these studies in our estimates.…”

Section: Methodsmentioning

confidence: 99%

New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB – a revised burden for India

Denning

Cole²,

Goel³

2023

IJID Regions

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“…This study adds to the existing data on co-occurrence of pulmonary aspergillosis with active P.TB-both clinico-radiologically and microbiologically diagnosed. 8,9,[16][17][18][19][20] CPA) and still found the proportions comparable (7% at baseline and 14.6% at the end-of-TB-therapy of proven CPA) to that reported by Setianingrum et al (7.9% at baseline and 13.3% at the end-of-TBtherapy of combined proven and probable CPA). 8 However, the significance of diagnosis of such CPA in P.TB pa-…”

Section: Discussionmentioning

confidence: 65%

Chronic pulmonary aspergillosis incidence in newly detected pulmonary tuberculosis cases during follow‐up

Jha,

Kumar,

Meena

et al. 2024

Mycoses

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BackgroundChronic pulmonary aspergillosis (CPA) is known to complicate patients with post‐tubercular lung disease. However, some evidence suggests that CPA might co‐exist in patients with newly‐diagnosed pulmonary tuberculosis (P.TB) at diagnosis and also develop during therapy. The objective of this study was to confirm the presence of CPA in newly diagnosed P.TB at baseline and at the end‐of‐TB‐therapy.Materials and MethodsThis prospective longitudinal study included newly diagnosed P.TB patients, followed up at third month and end‐of‐TB‐therapy with symptom assessment, anti‐Aspergillus IgG antibody and imaging of chest for diagnosing CPA.ResultsWe recruited 255 patients at baseline out of which 158 (62%) completed their follow‐up. Anti‐Aspergillus IgG was positive in 11.1% at baseline and 27.8% at end‐of‐TB‐therapy. Overall, proven CPA was diagnosed in 7% at baseline and 14.5% at the end‐of‐TB‐therapy. Around 6% patients had evidence of aspergilloma in CT chest at the end‐of‐TB‐therapy.ConclusionsCPA can be present in newly diagnosed P.TB patients at diagnosis and also develop during anti‐tubercular treatment. Patients with persistent symptoms or developing new symptoms during treatment for P.TB should be evaluated for CPA. Whether patients with concomitant P.TB and CPA, while receiving antitubercular therapy, need additional antifungal therapy, needs to be evaluated in future studies.

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“…This study adds to the existing data on co-occurrence of pulmonary aspergillosis with active pulmonary tuberculosis – both clinico-radiologically and microbiologically diagnosed. 8, 15, 16, 17, 18, 19, 9 . Table 3 describes the available literature on the frequency of CPA at various time points in active P.TB patients.…”

Section: Discussionmentioning

confidence: 99%

Chronic pulmonary aspergillosis incidence in newly detected pulmonary tuberculosis cases during follow-up

Jha,

Kumar,

Meena

et al. 2024

Preprint

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Background: Chronic pulmonary aspergillosis (CPA) is known to complicate patients with post-tubercular lung disease. However, some evidence suggests that CPA might co-exist in patients with newly-diagnosed pulmonary tuberculosis (P.TB) at diagnosis and also develop during therapy. The objective of this study was to confirm the presence of CPA in newly diagnosed P.TB at baseline and at end-of -therapy. Materials & Methods: This prospective longitudinal study included newly diagnosed P.TB patients, followed up at third month and end-of-therapy with symptom assessment, anti-Aspergillus IgG antibody and imaging of chest for diagnosing CPA. Results: We recruited 255 patients at baseline out of which 158 (62%) completed their follow-up. Anti-Aspergillus IgG was positive in 11.1% at baseline and 27.8% at end-of-therapy. Overall, proven CPA was diagnosed in 7% at baseline and 14.5% at end-of-therapy. Around 6% patients had evidence of aspergilloma in CT chest at the end-of-therapy. Conclusions: CPA can be present in newly diagnosed P.TB patients at diagnosis and also develop during anti-tubercular treatment . Patients with persistent symptoms or developing new symptoms during treatment for P.TB should be evaluated for CPA.

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Prevalence of chronic pulmonary aspergillosis and the antifungal drug resistance of ***Aspergillus*spp. in pulmonary tuberculosis patients in Uzbekistan**

Cited by 5 publications

References 25 publications

New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB – a revised burden for India

New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB – a revised burden for India

Chronic pulmonary aspergillosis incidence in newly detected pulmonary tuberculosis cases during follow‐up

Chronic pulmonary aspergillosis incidence in newly detected pulmonary tuberculosis cases during follow-up

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