Prevalence of class 1 integron in Escherichia coli isolated from animal sources in Iran: a systematic review and meta-analysis

Abstract

Background: Among the genetic elements, integrons may contribute to the widespread incidence and spreading of antibiotic resistance among Escherichia coli isolates. Accordingly, this review aims to investigate the prevalence of class 1 integron in E. coli isolated from animal sources in Iran. Methods: This systematic literature search was performed from January 1, 2000 to the end of May 1, 2019. Then, publications that met our inclusion criteria were selected for data extraction and analysis. Also, the quality of included studies was independently assessed by two researchers based on the Joanna Briggs Institute. Metaanalysis was performed by the Comprehensive Meta-Analysis (CMA) software using the random effects model, Cochran's Q, and I 2 tests. Publication bias was estimated by funnel plot and Egger's linear regression test. Results: Based on inclusion criteria, five studies were included to meta-analysis. From those studies, the pooled prevalence of integrons was 33% (95% CI, 23.8-43.7%) ranging from 23.8 to 52.4%. There was a significant heterogeneity among the 5 studies (χ 2 = 11.73; p < 0.019; I 2 = 65.91%). Additionally, Begg's and Egger's tests were performed to quantitatively evaluate the publication biases. According to the results of Begg's test (z = 1.22, p = 0.22) and Egger's test (t = 3.03, p = 0.056), a significant publication bias was not observed. Conclusions: Our finding revealed the relatively high prevalence of class 1 integrons among E. coli isolates. Moreover, there was a significant heterogeneity among studies and subgroup analysis also showed that there was no difference about prevalence of class 1 integrons among different sample source.

Occurrence of Serratia marcescens Carrying blaIMP-26 and mcr-9 in Southern China: New Insights in the Evolution of Megaplasmid IMP-26

“…These elements are capable of capturing, mobilizing, and integrating antibiotic-resistant gene cassettes [ 58 ]. Through lateral DNA transfer, they gained access to a variety of commensal and pathogenic bacteria and subsequently accumulate diverse antibiotic resistance genes [ 59 , 60 ]. The bla IMP-26 transfer mediated by class 1 integron might lead to the increase in carbapenem-resistant isolates, which are a risk to healthcare systems.…”

Occurrence, Phenotypic and Molecular Characteristics of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Healthy Turkeys in Northern Egypt

“…Metallo-beta-lactamase (MBL) and class 1 integron are mostly encoded on the same gene cassettes that are circulating in bacterial populations [ 60 ]. Furthermore, newly extended spectrum beta lactamases (ESBL)-encoding genes such as bla CTX-M, bla GES, and bla VEB-1 are typically found on integron-like structures [ 61 ].…”

Characterization of Integrons and Quinolone Resistance in Clinical Escherichia coli Isolates in Mansoura City, Egypt

“…Integrons have been described as an acquired resistance mechanism by capturing, excising, and expressing gene cassettes through site-specific recombination, thus aiding in the spread of antibiotic resistance [ 32 ]. In this study, integrons were found in 44.77% of the tested isolates, which is similar to other studies [ 10 , 12 ].…”