Prevalence of clinical isolates of Escherichia coli and Klebsiella spp. producing multiple extended-spectrum β-lactamases

A Study on Prevalence and Antimicrobial Resistance Pattern of Urinary Klebsiella pneumoniae in a Tertiary Care Centre in South India

“…than non-ESBL producing Klebsiella spp (Schwaber et al, 2006;Kim et al, 2002). ESBL producing Klebsiella pneumoniae isolated were 17.5% almost the same results were obtained in the other studies (Romero et al, 2007;El Bouamri et al, 2015). This study shows that 91.2% of isolates were susceptible to Imipenem.…”

“…Second and third generations cephalosporins are widely used in the treatment of infections caused by Klebsiella spp (Romero et al, 2007). Our strains showed moderate antibacterial resistance to the third generation cephalosporins, in contrary to the study conducted by Singh et al, (2003).…”

High Rate of Intestinal Colonization with Extended-Spectrum-β-Lactamase-Producing Organisms in Household Contacts of Infected Community Patients

“…This distribution is in agreement with the epidemiological situation of ESBL-producing strains from the community at the time of enrollment in our study (2,27,31). It is of note that two IC patients and two household contacts were colonized with two different ESBLproducing strains.…”

Comparative Effects of Carbapenems on Bacterial Load and Host Immune Response in aKlebsiella pneumoniaeMurine Pneumonia Model

“…Klebsiella pneumoniae is an increasingly important CAP pathogen, particularly in individuals with impaired pulmonary defenses, and is also a key pathogen in nosocomial pneumonia (42). Pulmonary infections caused by K. pneumoniae are often characterized by a rapid clinical course that includes multilobar involvement, formation of abscesses, and dissemination of bacteria from the pulmonary air space into the bloodstream, leading to widespread systemic effects and death (27,31,43). Treatment of K. pneumoniae infections can be complicated by the presence of extended-spectrum ␤-lactamases (ESBLs), which confer resistance to many broad-spectrum penicillin and cephalosporin antibiotics.…”

“…Treatment of K. pneumoniae infections can be complicated by the presence of extended-spectrum ␤-lactamases (ESBLs), which confer resistance to many broad-spectrum penicillin and cephalosporin antibiotics. K. pneumoniae in nosocomial infections is becoming more prevalent, with the global incidence of ESBLs in Klebsiella clinical isolates ranging from 8% to 44% (15,33,36,43). In the United States, TEM-and SHV-type ESBLs predominate among Enterobacteriaceae, while in Canada and Europe, SHV and CTX ESBLs, respectively, are most frequently reported (8).…”