Prevalence of co-infection between respiratory syncytial virus and influenza in children

Meskill, Sarah D.; Revell, Paula A.; Chandramohan, Lakshmi; Cruz, Andrea T.

doi:10.1016/j.ajem.2016.12.001

Cited by 29 publications

(25 citation statements)

References 8 publications

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“…This phenomenon is not unique to Israel, as a similar delay in RSV emergence was reported in various locations in Europe and was also observed with regard to other respiratory viruses, such as seasonal influenza and hMPV (19). In vitro studies support this indication, as it was reported that RSV and influenza share an ecologic niche (20), in which growth of RSV is blocked by competitive infection with influenza (21).…”

Section: Discussionsupporting

confidence: 75%

Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

Drori

Jacob‐Hirsch

Pando

et al. 2020

Preprint

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Influenza viruses and respiratory syncytial virus (RSV) are respiratory viruses that primarily circulate worldwide during the autumn and winter seasons. Seasonal surveillance shows that RSV infection generally precedes influenza. However, in the last four winter seasons (2016-2020) an overlap of the morbidity peaks of both viruses was observed in Israel, and was paralleled by significantly lower RSV infection rates. To investigate whether the influenza virus inhibits RSV we performed coinfection of Human cervical carcinoma (HEp2) cells or mice with influenza and RSV and we observed that the influenza inhibited RSV growth, both in vitro and in vivo. Mass spectrometry analysis of mouse lungs infected with influenza identified a two-wave pattern of protein expression upregulation, which included members of the interferon-induced protein with tetratricopeptide (IFITs) family. Interestingly, in the second peak of upregulation, influenza viruses were no longer detectable in mouse lungs. We also observed that knockdown and overexpression of IFITs in HEp2 cells affected RSV multiplicity. In conclusion, influenza infection inhibits RSV infectivity via upregulation of IFIT proteins in a two-wave modality. Understanding of the interaction between influenza and RSV viruses and immune system involvement will contribute to the development and optimization of future treatment strategies against these viruses.

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Section: Discussionsupporting

confidence: 75%

Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

Drori

Jacob‐Hirsch

Pando

et al. 2020

Preprint

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“…Infants and young children may be at a high risk of influenza virus infection [10,20,21]. Previous studies also confirmed that influenza virus and other pathogens, such as respiratory syncytial viruses (RSV), rhinoviruses and enteroviruses, might be more sensitive to immunocompromised or immunodeficient infants and young children, leading to concomitant or consecutive infection [21][22][23][24]. Our results highlighted that a very large amount of ILI cases emerged in younger age groups, which could provide evidence for the increasing literature confirming the population susceptible to influenza viruses.…”

Section: Discussionmentioning

confidence: 93%

Epidemiological features and time-series analysis of influenza incidence in urban and rural areas of Shenyang, China, 2010–2018

et al. 2020

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In recent years, there have been a significant influenza activity and emerging influenza strains in China, resulting in an increasing number of influenza virus infections and leading to public health concerns. The aims of this study were to identify the epidemiological and aetiological characteristics of influenza and establish seasonal autoregressive integrated moving average (SARIMA) models for forecasting the percentage of visits for influenza-like illness (ILI%) in urban and rural areas of Shenyang. Influenza surveillance data were obtained for ILI cases and influenza virus positivity from 18 sentinel hospitals. The SARIMA models were constructed to predict ILI% for January–December 2019. During 2010–2018, the influenza activity was higher in urban than in rural areas. The age distribution of ILI cases showed the highest rate in young children aged 0–4 years. Seasonal A/H3N2, influenza B virus and pandemic A/H1N1 continuously co-circulated in winter and spring seasons. In addition, the SARIMA (0, 1, 0) (0, 1, 2)12 model for the urban area and the SARIMA (1, 1, 1) (1, 1, 0)12 model for the rural area were appropriate for predicting influenza incidence. Our findings suggested that there were regional and seasonal distinctions of ILI activity in Shenyang. A co-epidemic pattern of influenza strains was evident in terms of seasonal influenza activity. Young children were more susceptible to influenza virus infection than adults. These results provide a reference for future influenza prevention and control strategies in the study area.

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“…All the 13 patients (100%) had abnormal radiological changes in their rst examination after admission. The median time from symptom onset to hospital admission was 4.5 days (IQR, 2.75-5.5), and the median time of hospital stay was 17 days (IQR, [15][16][17][18][19][20].…”

Section: Resultsmentioning

confidence: 99%

“…Viruses co-infection were usually seen in the in uenza epidemic and pandemic 19,20 . Goka et al found that IAV and in uenza B virus co-infection associated with a signi cant increase in risk of admission to ICU or death, whereas co-infection with IAV and other viruses signi cantly increased the risk of admission to a general ward 19 .…”

Section: Discussionmentioning

confidence: 99%

Co-infection of SARS-COV-2 and influenza A virus: a case series and fast review

Xuan

Wang

et al. 2020

Preprint

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Background: COVID-19 has become a global pandemic. Studies about SARS-CoV-2 co-infection with influenza A virus (IAV) in the influenza season will contribute to the antiviral interventions of co-infected patients.Methods: A cohort of 145 COVID-19 patients in Wuhan union hospital were reviewed and we found 2 patients were co-infected with both SARS-CoV-2 and IAV. Then we searched from PubMed, Web of Science and CNKI with combinations of the following key words: “COVID-19, SARS-COV-2, influenza A and co-infection” from January 1 up to May 1, and 6 studies were included in this descriptive analysis. Results: Of the 13 co-infected patients, 2 were from Wuhan union hospital, another 11 were collected from the reports published on PubMed, Web of Science and CNKI. Of the 13 patients, the median age was 50 years (IQR, 40.5-67.5). Among the 13 patients, 7 (53.8%) were severe types. The most common symptoms among the 13 patients were cough (100%), fever (92.3%) and dyspnea (76.9%). 8 patients had lymphocytopenia on admission and all the 13 patients had abnormal radiological changes. The median time from symptom onset to hospital admission was 4.5 days (IQR, 2.75-5.5), and the median time of hospital stay was 17 days (IQR,15-20). Conclusion: Patients with both SARS-COV-2 and IAV infection showed similar changes in symptoms and radiological images with patients infected with SARS-COV-2 only. SARS-COV-2 co-infection with IAV can lead to more severe clinical condition but had similar hospital stay compared with patients infected with SARS-COV-2 only in the fast review.

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Prevalence of co-infection between respiratory syncytial virus and influenza in children

Cited by 29 publications

References 8 publications

Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

Epidemiological features and time-series analysis of influenza incidence in urban and rural areas of Shenyang, China, 2010–2018

Co-infection of SARS-COV-2 and influenza A virus: a case series and fast review

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