Prevalence of coeliac disease in Northern Ireland

Johnston, S D; Watson, R. G. P.; McMillan, S. A.; Sloan, J. M.; Love, A. H. G.

doi:10.1016/s0140-6736(05)65142-2

Cited by 142 publications

(61 citation statements)

References 4 publications

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“…Before the development of powerful screening methods for coeliac disease, the prevalence of coeliac disease in Caucasian populations was generally estimated to be in the order of 0.1 % [6]. During the last few years, the invention of sensitive methods, especially of the assay for endomysium antibodies, has led to a number of reports giving considerably higher prevalence figures, ranging from 0.3 % up to 1.2 %, among both children and adults [7,8]. Using the same endomysium antibody method, we previously found a prevalence of coeliac disease of 0.8 % among 1070 Finnish adults [9].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1 * 02 allele

et al. 2001

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Increased prevalence of coeliac disease in patients with Type I diabetes has been widely reported in Caucasian populations, with figures for prevalence varying from 1.0 to 7.8 % [1]. Certain HLA genotypes (especially, those positive for DR3-DQ2 haplotype) are more frequent in both of these diseases. First-degree relatives of patients with Type I diabetes have an increased risk for developing diabetes, a risk that is proportional to the degree of shared HLA risk alleles. It

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Section: Discussionmentioning

confidence: 99%

Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1 * 02 allele

et al. 2001

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“…13 Epidemiological studies, performed by accurate serological screening in the general population, have radically changed our knowledge about CD prevalence, showing that the disease occurs worldwide much more frequently than previously thought (Table 1). [14][15][16][17][18][19][20][21] The highest reported prevalence is in Europe: 1 in 99 in Finland, 1 in 122 in Northern Ireland and 1 in 175 people in Italy. 16,20,21 Until a few years ago, gluten-sensitive enteropathy was erroneously considered uncommon in the United States, but serological screening in healthy blood donors has revealed a prevalence approaching that of Europe (1 in 250).…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16][17][18][19][20][21] The highest reported prevalence is in Europe: 1 in 99 in Finland, 1 in 122 in Northern Ireland and 1 in 175 people in Italy. 16,20,21 Until a few years ago, gluten-sensitive enteropathy was erroneously considered uncommon in the United States, but serological screening in healthy blood donors has revealed a prevalence approaching that of Europe (1 in 250). 22 Whereas CD is well documented in Asians from India and Pakistan, 23 it is rare among native Japanese and Chinese.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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Until a few years ago, celiac disease (CD) was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal mucosa. Currently, CD is regarded as an autoimmune disorder that is common in the general population (affecting 1 in 100 individuals), with possible onset at any age and with many possible presentations. The identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal (constipation and recurrent abdominal pain) and extra-intestinal symptoms (anemia, raised transaminases, osteoporosis, recurrent miscarriages, aphthous stomatitis and associated autoimmune disorders), or it could be completely symptomless. Over the last 20 years, the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests, such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide antibodies. The routine use of antibody markers has allowed researchers to discover a very high number of 'borderline' cases, characterized by positive serology and mild intestinal lesions or normal small intestine architecture, which can be classified as potential CD. Therefore, it is evident that the 'old celiac disease' with flat mucosa is only a part of the spectrum of CD. It is possible that serology could identify CD in its early stages, before the appearance of severe intestinal damage. In cases with a positive serology but with mild or absent intestinal lesions, the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

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“…3 IgA nephropathy, immune complex-associated or membranoproliferative glomerulonephritis are the most common forms of renal involvement in patients with Celiac disease. 4 Secondary forms of FSGS are generally considered to result from maladaptive responses that occur due to loss of functioning nephrons, hyperfiltration or increased glomerular pressure. It was demonstrated that loss of podocytes which starts with injury to the podocytewas pivotal in FSGS resulting from these maladaptive responses.…”

Section: A Case Of Celiac Disease With Focal Segmental Glomerulosclermentioning

confidence: 99%

A Case of Celiac Disease with Focal Segmental Glomerulosclerosis Leading to End-Stage Renal Disease

Can¹,

Bilge²,

Şirin³

et al. 2012

Turkiye Klinikleri J Med Sci

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Prevalence of coeliac disease in Northern Ireland

Cited by 142 publications

References 4 publications

Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1 * 02 allele

Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1 * 02 allele

Celiac disease: diagnostic criteria in progress

A Case of Celiac Disease with Focal Segmental Glomerulosclerosis Leading to End-Stage Renal Disease

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