Prevalence of Coeliac Disease: Unexplained Age-related Variation in the Same Population

Pratesi, Riccardo; Gandolfi, Lenora; Garcia, Steven; Modelli, Inês Cristina; Almeida, Patrícia Lopes de; Bocca, Anamélia Lorenzetti; Catassi, Carlo

doi:10.1080/00365520310003255

Cited by 59 publications

(16 citation statements)

References 20 publications

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“…Another interesting finding regarding CD prevalence is the difference between children and adults. In contrast to other studies 30,32,33 that have shown a higher CD prevalence in children compared to adults, we found that the prevalence of CD was similar between children age 6–18 and adults. This difference between studies may be due to population selection or small sample size of previous studies, most of which were conducted in selected populations from referral centers.…”

Section: Discussioncontrasting

confidence: 99%

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Less Hidden Celiac Disease But Increased Gluten Avoidance Without a Diagnosis in the United States

Choung

Ünalp–Arida

Ruhl

et al. 2017

Mayo Clinic Proceedings

108

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Objective To investigate the trends of diagnosed celiac disease (CD), undiagnosed CD, and people without CD avoiding gluten (PWAG) in the civilian non-institutionalized US population from 2009 to 2014. Patients and Methods We studied the occurrence of CD and PWAG in the 2009–2014 National Health and Nutrition Examination Surveys (NHANES). The sera of all participants 6 years and older from NHANES 2009–2014 were tested for CD serology at Mayo Clinic. Participants were interviewed about a diagnosis of CD and the use of a gluten-free diet (GFD). The design effects of the survey and sample weights were incorporated in all statistical analyses. Results In the US general population, the prevalence of CD did not significantly change from 2009–2010 [0.7%, 95% CI (0.6–0.8)] to 2011–2012 [0.8%, 95% CI (0.4–1.2)] to 2013–2014 [0.7%, 95% CI (0.3–1.0)]. However, the prevalence of undiagnosed CD decreased from 0.6% in 2009–2010 to 0.3% in 2013–2014. In contrast, the prevalence of PWAG significantly increased from 0.5% (95% CI, 0.2–0.9) in 2009–2010 to 1.0% (95% CI, 0.6–1.4) in 2011–2012 to 1.7% (95% CI, 1.1–2.4) in 2013–2014 (P for trend = .005). Conclusion While the overall prevalence of CD remained stable between 2009 and 2014, the proportion CD that is hidden significantly decreased. Moreover, the prevalence of individuals without CD but following a GFD markedly increased between 2009 and 2014. Long-term health consequences of GFD warrant further investigation.

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Section: Discussioncontrasting

confidence: 99%

“…This difference between studies may be due to population selection or small sample size of previous studies, most of which were conducted in selected populations from referral centers. 32,33 …”

Section: Discussionmentioning

confidence: 99%

Less Hidden Celiac Disease But Increased Gluten Avoidance Without a Diagnosis in the United States

Choung

Ünalp–Arida

Ruhl

et al. 2017

Mayo Clinic Proceedings

108

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“…In Brazil, several prevalence studies performed to date revealed significant differences around the country, probably consequent to genetic and environmental factors and possibly also due to interlaboratory assay variability [3–7]. Although multicenter epidemiological studies that could yield reliable information on CD prevalence in Brazil are still lacking, the existing reports suggest that the disease prevalence in this country is similar to the general prevalence found in other areas of the world [2, 4, 5, 7]. …”

Section: Introductionmentioning

confidence: 86%

Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease

Almeida

Gandolfi

Pratesi

et al. 2016

Autoimmune Diseases

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Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development. Materials and Methods. 237 celiac patients and 237 controls (both groups with 164 females and 73 males) were included. All samples were tested for the presence of predisposing HLA-DQ alleles using the PCR-SSP method. Results were considered significant when p < 0.05. Disease risk was expressed as 1 : N for each HLA-DQ category described at this study. Results. DQ2.5 and/or DQ8 were detected in 224 celiac patients (94.5%) and 84 controls (35.4%). Eight celiac patients (3.4%) and 38 controls (16%) disclosed only DQ2.2. Even though DQ2.2 (β2/β2 or β2/x) showed a low CD risk of 1 : 251 and 1 : 550, respectively, the genotype DQ2.5/DQ2.2 (β2/β2) showed high CD risk of 1 : 10 (p < 0.0001). The disease risk gradient ranged from 1 : 3014 to 1 : 7. Conclusion. Our study allowed the determination of a risk gradient for celiac disease development in at-risk population, showing that DQ2.2 variant was relevant when associated with DQ2.5.

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“…An uneven prevalence for CD has been detected in different Brazilian regions, ranging from 1:119 to 1:417 in the general population [5,6] and from 1:214 to 1:681 in presumed healthy blood donors [7,8]. This is probably due to variances in environmental factors, dietary habits, and ethnic composition of the population.…”

Section: Introductionmentioning

confidence: 99%

Screening for celiac disease in 1st degree relatives: a 10-year follow-up study

et al. 2014

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BackgroundAlthough it is known that first degree relatives of celiac patients have an increased risk for celiac disease few studies are available on its incidence. We investigated the incidence of serologic conversion and of new cases of celiac disease among first degree relatives with negative results at a first screening.MethodsFrom a total of 634 first degree relatives of 186 biopsy-proven celiac disease patients diagnosed between October 2000 and October 2010, 450 subjects agreed to participate in the study (Group I), and underwent serologic screening. Between January 2010 and October 2012, out of the initial group of 450, 205 previously sero-negative subjects consented to participate in a second stage of the study and undergo new serologic testing (Group II). All serologically positive individuals of both groups (I and II) were genotyped for celiac disease-predisposing alleles (HLA-DQ2/DQ8).Results19 subjects (4.2%) out of the 450 subjects of Group I disclosed positive serologic results, presence of DQ2 and/or DQ8 alleles and celiac disease-compatible mucosal abnormalities. The 205 previously negative first degree relatives from Group II that underwent new serologic testing disclosed eight sero-converted subjects. Mucosal abnormalities in five of these patients confirmed the diagnosis of celiac disease. During the 10-year period of the study the incidence of sero-conversion was 8/205 and the incidence of biopsy-proven celiac disease cases was 5/205.ConclusionsOur data are coincident with other works on this subject and confirm once again that relatives of celiac patients, especially first degree relatives are at high risk of developing celiac disease. In view of the relatively low incidence further studies are needed to try to establish a useful and cost-effective algorithm for follow-up of relatives of celiac patients.

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Prevalence of Coeliac Disease: Unexplained Age-related Variation in the Same Population

Abstract: This work supports previous findings showing that CD is not a rare disorder in Brazil and that there is an unexplained difference in the prevalence of CD between adults and children.

Cited by 59 publications

References 20 publications

Less Hidden Celiac Disease But Increased Gluten Avoidance Without a Diagnosis in the United States

Less Hidden Celiac Disease But Increased Gluten Avoidance Without a Diagnosis in the United States

Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease

Screening for celiac disease in 1st degree relatives: a 10-year follow-up study

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