Prevalence of Coexistence of Coronary Artery Disease, Ischemic Stroke, and Peripheral Arterial Disease in Older Persons, Mean Age 80 Years, in an Academic Hospital‐Based Geriatrics Practice

Ness, J. Mark Van; Aronow, Wilbert S.

doi:10.1111/j.1532-5415.1999.tb05208.x

Cited by 216 publications

(133 citation statements)

References 10 publications

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“…Leng et al also showed that patients with asymptomatic PAOD appear to have the same increased risk of cardiovascular events and death as symptomatic patients 20) . Therefore, identifying high-risk PAOD patients is due to concomitant coronary artery disease and cerebrovascular disease; these cardiovascular events are more frequent than ischemic limb events in such patients 17,18) . Criqui et al reported mortality rates in patients with PAOD after a 10-year follow-up period.…”

Section: Incidence Of Paod In Taiwanmentioning

confidence: 99%

CHADS<sub>2</sub> Score and Risk of New-onset Peripheral Arterial Occlusive Disease in Patients without Atrial Fibrillation: A Nationwide Cohort Study in Taiwan

Hsu

Chiu

Chu

et al. 2015

JAT

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Aim: Although our recent cross-sectional study demonstrated that the CHADS2 score is associated with an ankle-brachial index of 0.9 in patients without atrial fibrillation (AF), the true cause-effect relationship between these parameters remains to be evaluated. Hence, the aim of this study was to investigate whether the CHADS2 score is a useful predictor of new-onset PAOD in non-AF patients. (score 5) and 291 (score 6) patients were studied and followed for the onset of PAOD. We further divided the study patients into four groups: group 1 (score 0), group 2 (score 1-2), group 3 (score 3-4) and group 4 (score 5-6). Results: During the follow-up period of 9.83 0.01 years, 24,775 (3.4%) patients experienced newonset PAOD. The overall incidence of PAOD was 0.6 per 1,000 patient-years. The rate of PAOD increased from 1.8% (group 1) to 18.7% (group 4) (p 0.001). According to a multivariate analysis, groups 2-4 were significantly associated with new-onset PAOD (all p 0.001). In addition, the hazard ratio of each two-point increment in the CHADS2 score for predicting PAOD was 2.51 (p 0.001). Conclusions: The CHADS2 score is a useful predictor of new-onset PAOD in non-AF patients. J Atheroscler Thromb, 2015; 22: 490-498.

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Section: Incidence Of Paod In Taiwanmentioning

confidence: 99%

CHADS<sub>2</sub> Score and Risk of New-onset Peripheral Arterial Occlusive Disease in Patients without Atrial Fibrillation: A Nationwide Cohort Study in Taiwan

Hsu

Chiu

Chu

et al. 2015

JAT

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“…[1][2][3][4] Previous studies reported that the prevalence of coronary artery disease (CAD) in patients with PAD is 46 to 71%. 5,6) In addition, coexistence of CAD is the most important determinant of mortality and longterm prognosis in patients with PAD 1,7,8) and patients with PAD had the same relative risk of death as those with a previous cardiovascular event.…”

Section: P Eripheral Artery Disease (Pad) Is Frequently Accompa-mentioning

confidence: 99%

Prediction of Coronary Artery Disease in Patients With Lower Extremity Peripheral Artery Disease

Cho

Kim

et al. 2015

Int. Heart J.

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SummaryCoronary artery disease (CAD) is a major determinant of long-term prognosis in patients with peripheral artery disease (PAD). We investigated the predictors of CAD in patients with lower extremity PAD.A total of 107 patients with PAD who underwent peripheral and simultaneous coronary angiography were reviewed. PAD was defined as (≥ 50%) stenosis associated with claudication or critical limb ischemia. PAD was divided into proximal and distal lesions. CAD was defined as angiographically significant (≥ 50%) stenosis of coronary arteries.The prevalence of CAD in patients with PAD was 62% (67/107), and of this 62%, only 13% (9/67) had angina and 72% (48/67) had multi-vessel disease. Diabetes significantly increased the risk of CAD in patients with PAD and the odds ratio of having multi-vessel CAD was 2.5 (1.1-5.9, P = 0.037) in multivariate regression analysis. The patients with multi-vessel CAD had more cardiovascular risk factors than those with normal, minimal and single CAD (P = 0.032). Interestingly, the prevalence of proximal PAD was higher in the normal or single CAD group than the multi-vessel CAD group, whereas both proximal and distal involvement of PAD was higher in the multi-vessel CAD group.Diabetes, multi-cardiovascular risk factors, and involvement of both proximal and distal lesions significantly increased the risk of multi-vessel CAD. Therefore, simultaneous CAD evaluation should be considered in patients with lower extremity PAD having diabetes, multi-cardiovascular risk factors, or multi-level disease. (Int Heart J 2015; 56: 209-212)

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“…17) Conversely, the frequencies of concurrence of CS in CAD and PAD patients have also been reported. 11,29) Kawarada et al 16) observed that CAD was complicated by CS in 13.7% and by PAD in 15.3% of the 380 patients who underwent elective CABG and reported the necessity of screening patients with cardiovascular risk factors for atherosclerotic diseases. 11) Marek et al 29) performed carotid artery ultrasound in 188 patients showing claudication with no history of cerebrovascular disorder and reported that ≥50% internal CS was noted in 24.5% and that it was occluded in 2.7%.…”

Section: Discussionmentioning

confidence: 99%

“…8,9) In actual clinical settings, we often encounter patients with CS complicated by other atherosclerotic diseases and those in whom CS is incidentally detected during the treatment for other atherosclerotic diseases such as CAD. 10,11) In revascularization for CS, CAD has been reported to be a risk factor for early as well as late death, 12) and PAD makes it difficult to perform CAS by the femoral approach and often limits devices and techniques that can be used. Thus, the concurrence of various atherosclerotic diseases affects the therapeutic strategy and outcomes of CS, but reports on the frequencies of CAD, PAD, and RAS as comorbidities of CS have been few.…”

Section: Introductionmentioning

confidence: 99%

Carotid Artery Stenosis as a Part of Atherosclerosis

Seguchi

Shibata

Nakajima

et al. 2018

JNET

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Objective: There have been few reports on the frequency of atherosclerotic diseases complicating carotid artery stenosis. This study was conducted to clarify the frequency of various atherosclerotic diseases concurrent with carotid artery stenosis that required revascularization. Methods:Examinations concerning various atherosclerotic diseases were reviewed using clinical records of 152 consecutive patients who underwent carotid artery stenting from January 2012 to October 2016 at our hospital. The patients were also divided into those with systemic atherosclerosis (SA group) and those without SA (non-SA group), and their characteristics were analyzed. Results:Of the 152 patients, carotid artery stenosis was complicated by other atherosclerotic diseases in 50 (32.9%), of whom 28 (18.4%) had coronary artery disease, 23 (15.1%) had peripheral artery disease, and 3 (2.0%) had renal artery stenosis. In the SA group, the frequencies of diabetes and dyslipidemia were significantly higher, hemoglobin A1c (HbA1c) level was higher, and high-density lipoprotein (HDL) cholesterol level and estimated glomerular filtration rate (eGFR) were lower. Conclusion:Carotid artery stenosis that required revascularization was frequently complicated by other atherosclerotic diseases. It is considered necessary to treat carotid artery stenosis with the prevention of cardiovascular events.

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Prevalence of Coexistence of Coronary Artery Disease, Ischemic Stroke, and Peripheral Arterial Disease in Older Persons, Mean Age 80 Years, in an Academic Hospital‐Based Geriatrics Practice

Cited by 216 publications

References 10 publications

CHADS<sub>2</sub> Score and Risk of New-onset Peripheral Arterial Occlusive Disease in Patients without Atrial Fibrillation: A Nationwide Cohort Study in Taiwan

CHADS<sub>2</sub> Score and Risk of New-onset Peripheral Arterial Occlusive Disease in Patients without Atrial Fibrillation: A Nationwide Cohort Study in Taiwan

Prediction of Coronary Artery Disease in Patients With Lower Extremity Peripheral Artery Disease

Carotid Artery Stenosis as a Part of Atherosclerosis

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