Prevalence of cognitive frailty among community-dwelling older adults: A systematic review and meta-analysis

Qiu, Yiming; Li, Guichen; Wang, Xinxin; Zheng, Lufang; Wang, Chunyan; Chen, Li

doi:10.1016/j.ijnurstu.2021.104112

Cited by 85 publications

(66 citation statements)

References 58 publications

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“…We computed PAR for three types of frailty for which global prevalence was accessible as follows: physical frailty (12%) ( O’Caoimh et al, 2021 ), cognitive prefrailty/frailty (9%) ( Qiu et al, 2022 ), and biopsychosocial frailty (26.8%) ( Veronese et al, 2021 ). The PAR was 5.87, 4.22, and 9.90%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Multi-Concept Frailty Predicts the Late-Life Occurrence of Cognitive Decline or Dementia: An Updated Systematic Review and Meta-Analysis of Longitudinal Studies

Guo

Sun

Tan

et al. 2022

Front. Aging Neurosci.

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BackgroundFrailty is a multidimensional syndrome that increases an individual’s vulnerability for developing adverse health outcomes, which include dementia. It might serve as a promising target for dementia prevention. However, there are currently no studies summarizing the association between multi-concept frailty and the risk of cognitive disorders. This study aims to summarize the evidence of associations between multi-concept frailty and cognitive disorders based on longitudinal studies.MethodsScopus, The Cochrane Library, PsycINFO, CINAHL, PubMed, and EMBASE databases were searched from inception to January 2, 2022. Longitudinal studies, which explored the association of frailty with incident risk of cognitive decline or dementia, were included. The multivariable-adjusted effect estimates were pooled by random-effects models. The evidence credibility was depicted according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method.ResultsA total of 30 longitudinal studies were included. Four types of frailty concepts were involved, including physical, cognitive, social, and biopsychosocial frailty. The meta-analysis comprised 20 studies of 252,571 older adults (mean age: 64.1–80.4 years), among whom 7,388 participants developed cognitive decline or dementia. Physical frailty was associated with higher risk of developing cognitive disorders [pooled relative risk (pRR) = 1.52, 95% confidence interval (CI): 1.28–1.80, I2 = 21.2%, pRR = 1.62 for cognitive decline, 95% CI: 1.07–2.45, I2 = 40.2%, pRR = 1.37 for all-cause dementia (ACD), 95% CI: 1.13–1.66, I2 = 0.0%]. Cognitive frailty (pRR = 2.90, 95% CI: 1.28–6.55, I2 = 78.1%) and pre-frailty (pRR = 4.24, 95% CI: 2.74–6.56, I2 = 30.2%) were linked to higher risk of ACD. Biopsychosocial frailty could predict a 41% (pRR = 1.41, 95% CI: 1.17–1.71) elevated risk of cognitive decline or dementia [pRR = 1.53 (95% CI: 1.19–1.96) for ACD and 1.11 (95% CI: 1.05–1.17) for Alzheimer’s disease (AD)]. In the systematic review, social frailty was associated with a 53% higher risk of AD. Preventing frailty could avoid a maximum of 9.9% cognitive disorders globally. The overall evidence strength is rated as low-to-moderate. Inconsistency and imprecision are major sources of bias.ConclusionFrailty in late life is a promising risk factor for cognitive disorders. Frail elderly should be monitored for their cognitive dynamics and initiate early prevention of dementia.Systematic Review Registrationwww.ClinicalTrials.gov, identifier CRD4202127 3434.

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Section: Resultsmentioning

confidence: 99%

Multi-Concept Frailty Predicts the Late-Life Occurrence of Cognitive Decline or Dementia: An Updated Systematic Review and Meta-Analysis of Longitudinal Studies

Guo

Sun

Tan

et al. 2022

Front. Aging Neurosci.

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“…While the psychometrically appropriate measures for this novel construct need further investigation, cognitive frailty is mainly diagnosed with clinical evaluations including MMSE, executive tests, gait speed, grip strength, weight loss, and psychological markers [8]. A recent systematic review found that the prevalence of cognitive frailty reaches 9% in community-dwelling older adults, and has increased in recent years [9]. Evidence showed that a variety of socio-demographic factors and health conditions can increase the risk of cognitive frailty, such as advanced age, low schooling, comorbidity, malnutrition, low social participation, sedentary lifestyle, and insomnia [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Understanding the dynamics of a research front is essential for researchers to be able to identify hotspots and emerging trends in the body of scientific knowledge [17]. Although several reviews have been conducted for cognitive frailty [9,10,12,13,18,19], no studies have previously attempted to analyze the development of cognitive frailty research since its definition was officially proposed. Bibliometric analysis enables researchers to unpack the evolutionary nuances of a specific field while shedding light on the emerging areas in that field by making sense of large volumes of unstructured data in rigorous ways [20].…”

Section: Introductionmentioning

confidence: 99%

Global Research on Cognitive Frailty: A Bibliometric and Visual Analysis of Papers Published during 2013–2021

Hui

Wang

Zhou

et al. 2022

IJERPH

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This study analyzed the current status, hotspots, and emerging trends of global research on cognitive frailty, in order to provide new research ideas for researchers. Articles and reviews related to cognitive frailty, published from 2013 to 2021, were retrieved from the Web of Science Core Collection (WoSCC) database on 26 November 2021. CiteSpace 5.8.R3 was employed for data analyses. A total of 2077 publications were included. There has been a rapid growth of publications on cognitive frailty research since 2016. The United States, Italy, England, and Australia have been the leading research centers of cognitive frailty; however, China has also recently focused on this topic. The National Center for Geriatrics and Gerontology, and Shimada H. were found to be the most prolific institution and author, respectively. Co-citation analysis identified 16 clusters, of which the largest was cognitive frailty. The keywords which occurred most frequently were “older adult”, followed by “cognitive impairment”, “frailty”, “risk”, “dementia”, “prevalence”, “mortality”, “health”, and “Alzheimer’s disease”. Burst keyword detection revealed a rising interest in cognitive frailty models. By analyzing these publications from recent years, this study provides a comprehensive analysis of cognitive frailty research.

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“…Since 2013, cognitive frailty as a new concept has raised a broad range of attentions from ageing health practitioners and researchers worldwide. In a recent systematic review, the pooled prevalence of cognitive frailty among community-dwelling older adults was reported to be 9% and has increased in recent years [7]. Evidence showed that a variety of socio-demographic factors and health conditions can increase the risk of cognitive frailty, such as advanced age, low schooling, comorbidity, malnutrition, low social participation, sedentary lifestyle, and insomnia [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Although several reviews have been conducted for cognitive frailty of older adults [7,8,10,11,16,17], no studies have previously attempted to analyze the development of cognitive frailty research since its de nition was o cially proposed. Bibliometric analysis enables researchers to unpack the evolutionary nuances of a speci c eld while shedding light on the emerging areas in that eld by making sense of large volumes of unstructured data in rigorous ways [18].…”

Section: Introductionmentioning

confidence: 99%

Global Research On Cognitive Frailty: A Bibliometric and Visual Analysis of Papers Published During 2013 – 2021

Hui

Wang

Zhou

et al. 2022

Preprint

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Background: Cognitive frailty relates to various adverse health outcomes of older adults and is proposed as a new target of healthy ageing. This study aimed to analyze the status, hotspots, and emerging trends / frontiers of global research on cognitive frailty.Methods: Articles and reviews related to cognitive frailty of older people published from 2013 to 2021 were retrieved from the Web of Science Core Collection (WoSCC) database on 26 November 2021. CiteSpace 5.8.R3 was used to conduct the collaboration analysis, document co-citation analysis, and keyword co-occurrence analysis.Results: A total of 2,077 publications were included. There has been a rapid growth of publications on cognitive research since 2016. The United States, Italy, England, and Australia were the leading research centers of cognitive frailty; however, China has recently focused on this topic. The National Center for Geriatrics and Gerontology and Shimada H. were found to be the most prolific institution and author, respectively. Co-citation analysis identified 16 clusters, of which the largest was cognitive frailty. The most frequently occurred keyword was older adult, followed by cognitive impairment, frailty, risk, dementia, prevalence, mortality, health, and Alzheimer’s disease. Burst keyword detection revealed a rising interest in cognitive frailty models.Conclusions: By analyzing the publications over the past years, this study provides a comprehensive analysis of cognitive frailty research. A variety of visualized networks oﬀer an in-depth understanding of the countries / regions, institutions, authors, hotspots, and research frontiers.

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Prevalence of cognitive frailty among community-dwelling older adults: A systematic review and meta-analysis

Cited by 85 publications

References 58 publications

Multi-Concept Frailty Predicts the Late-Life Occurrence of Cognitive Decline or Dementia: An Updated Systematic Review and Meta-Analysis of Longitudinal Studies

Multi-Concept Frailty Predicts the Late-Life Occurrence of Cognitive Decline or Dementia: An Updated Systematic Review and Meta-Analysis of Longitudinal Studies

Global Research on Cognitive Frailty: A Bibliometric and Visual Analysis of Papers Published during 2013–2021

Global Research On Cognitive Frailty: A Bibliometric and Visual Analysis of Papers Published During 2013 – 2021

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