Prevalence of cognitive impairment in Chinese older inpatients and its relationship with 1-year adverse health outcomes: a multi-center cohort study

Li, Yuan; Zhang, Xiaoming; Guo, Na; Li, Zhen; Lv, Dongmei; Wang, Hui; Jin, Jingfen; Wen, Xiaozhong; Zhao, Shengxiu; Xu, Tao; Jiao, Jing; Wu, Xinjuan

doi:10.1186/s12877-021-02556-5

Cited by 20 publications

(10 citation statements)

References 69 publications

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“…Гендерные различия в когнитивных функциях были выявлены у здоровых мужчин и женщин, а также у пациентов с сердечнососудистыми заболеваниями [7][8][9]. В недавнем популяционном исследовании показано, что распространенность когнитивных нарушений у женщин выше (25,17% vs 16,85%), чем у мужчин, а также установлена связь между когнитивным дефицитом и повышенной смертностью на протяжении 1 года наблюдения [10]. В ряде других исследований показана связь между когнитивными нарушениями, депрессией и тревогой [11][12][13].…”

Section: оригинальные исследованияunclassified

Gender Characteristics of Postoperative Cognitive Dysfunction in Patients Undergoing Coronary Artery Bypass Grafting

Соснина¹,

И.В.²,

Д.С.³

et al. 2023

Кардиология В Беларуси

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Введение. Послеоперационная когнитивная дисфункция (ПОКД) является частым осложнением коронарного шунтирования (КШ), характеризующимся нарушением памяти и способности к обучению, снижением внимания и скорости обработки информации. На сегодняшний день влияние фактора пола на развитие ПОКД после операции КШ практически не изучалось. Цель. Изучить гендерные особенности развития ПОКД в раннем послеоперационном периоде у пациентов, перенесших КШ. Материалы и методы. В проспективное когортное исследование включены 50 мужчин и 31 женщина в возрасте от 45 до 70 лет, поступившие на плановое КШ. Все пациенты проходили предоперационное клинико-инструментальное обследование и двухэтапную оценку когнитивных функций: нейропсихологический скрининг с использованием Монреальской шкалы когнитивной дисфункции и расширенное нейропсихологическое тестирование показателей исполнительных и психомоторных функций, внимания и кратковременной памяти, на 8–11-е сутки после КШ повторно проводилось расширенное тестирование с определением ПОКД согласно критерию «20%-20%». Статистическую обработку данных проводили по программе STATISTICA 10 (StatSoft, Inc., США). Результаты. Установлено, что пациенты женского пола чаще страдают от развития ПОКД, чем мужчины (74% vs 56%), отношение шансов (OR) составило 2,24, 95% ДИ (CI) 1,23–4,06, p=0,01. В структуре ПОКД у мужчин наблюдаются нарушения функций всех когнитивных доменов: психомоторных и исполнительных функций, внимания и кратковременной памяти, тогда как у женщин чаще отмечаются комбинации нарушений памяти с вниманием или исполнительными функциями. Бинарная логистическая регрессия позволила выявить ассоциации стенозов сонных артерий, сахарного диабета 2-го типа и высокого уровня тревожности с риском развития ПОКД, тогда как пол пациентов был менее значим, χ2=20,06; p=0,001. Заключение. В настоящем исследовании выявлены гендерные особенности в развитии ПОКД в раннем послеоперационном периоде у пациентов, перенесших КШ. Пациенты женского пола чаще страдают от развития ПОКД, чем мужчины. У мужчин чаще наблюдаются нарушения во всех когнитивных доменах, тогда как у женщин чаще отмечаются комбинации нарушений памяти с вниманием или исполнительными функциями. Более значимыми независимыми факторами риска развития ПОКД, чем пол пациентов, были наличие стенозов сонных артерий, сахарного диабета 2-го типа и высокий уровень тревожности. Introduction. Postoperative cognitive dysfunction (POCD) is a common complication of coronary artery bypass grafting (CABG) characterized by impaired memory and learning ability, decreased attention and speed of information processing. To date, the effect of gender on the development of POCD after CABG has not been studied. Purpose. To study the gender characteristics of POCD in the early postoperative period in patients undergoing CABG. Materials and methods. The prospective cohort study included 50 men and 31 women aged between 45 and 70 admitted for elective CABG. All patients underwent a preoperative clinical and instrumental examination and a two- stage cognitive functions assessment: neuropsychological screening using the Montreal Cognitive Assessment scale and extended neuropsychological testing of indicators of executive and psychomotor functions, attention and short-term memory, extended testing was repeated at 8–11 days after CABG with the definition of POCD according to the criterion «20%-20%». Statistical data processing was performed using the STATISTICA 10.0 (StatSoft, Inc., USA). Results. Female patients were found to be more likely to develop POCD than males (74% vs 56%), with an odds ratio (OR) of 2.24, p=0.01. In the POCD structure in men, impaired functions of all cognitive domains were observed: psychomotor and executive functions, attention, and short-term memory, whereas in women combinations of memory disorders with attention or executive functions are more frequently observed. Binary logistic regression revealed associations of carotid artery stenosis, type 2 diabetes mellitus, and high levels of anxiety with the POCD risk, whereas patient gender had a lesser significance, χ2=20.06; p=0.001. Conclusion. This study revealed gender characteristics in the development of POCD in the early postoperative period in CABG patients. Female patients are more likely to develop POCD than males. Male patients are more likely to experience cognitive decline in all domains, while women are more likely to experience combinations of memory impairment with attention or executive functions. The presence of carotid stenosis, type 2 diabetes mellitus and a high level of anxiety were the more significant independent risk factors for the POCD development than patient gender.

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Section: оригинальные исследованияunclassified

Gender Characteristics of Postoperative Cognitive Dysfunction in Patients Undergoing Coronary Artery Bypass Grafting

Соснина¹,

И.В.²,

Д.С.³

et al. 2023

Кардиология В Беларуси

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“…Cognitive deficits can additionally lead to other health problems. Yuan et al found that old adults with cognitive impairment aged over 75 years have a higher risk of death and of suffering from frailty in one year compared with those aged between 65–74 years [ 20 ]. Therefore, current studies define old adults aged between 60–75 as young-old and those aged above 75 as old-old adults, and it is important to investigate the association between SCD within each age category.…”

Section: Introductionmentioning

confidence: 99%

Mental Fatigue Is Associated with Subjective Cognitive Decline among Older Adults

Zhang

Sun

et al. 2023

Brain Sciences

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Both Subjective Cognitive Decline (SCD) and mental fatigue are becoming increasingly prevalent as global demographics shifts indicate our aging populations. SCD is a reversible precursor for Alzheimer’s disease, and early identification is important for effective intervention strategies. We aim to investigate the association between mental fatigue—as well as other factors—and SCD. A total of 707 old adults (aged from 60 to 99) from Shanghai, China, participated in this study and completed self-reported instruments covering their cognitive and mental status as well as demographic information. Mental fatigue status was assessed by using four items derived from the functional impairment syndrome of the Old Adult Self Report (OASR). SCD was assessed by using the Memory/Cognition syndrome of OASR. A total of 681 old adults were included in the current study. The means of SCD significantly differed between each group of factors (age, gender, and mental fatigue). The general linear regression models showed that SCD increased with age, females scored higher than males, and SCD was positively associated with mental fatigue factors including difficulty getting things done, poor task performance, sleeping more, and a lack of energy among old adults. The study also found that SCD is negatively associated with the high-income group among young-old (aged from 60 to 75) males and associated with good marital/living status with the companion of spouses/partners among young-old females. These results suggest that gender, income level, marital/living status, and mental fatigue are crucial factors in preventing SCD among old adults and are pivotal in developing early intervention strategies to preserve the mental health of an increasingly aging population.

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“…Several recent studies have identified severity of frailty across various conditions, including old age, female sex, and reduced concentration and motivation. [4,5,8–41] However, high-quality systematic reviews are still in demand. Overall, we conducted this project to study the risk factors for frailty.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for frailty in older adults

Wang

2022

Medicine

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Aims: To clarify the risk factors for frailty to help doctors prevent diseases that cause weakness, through early interventions. Methods: We searched the PubMed, EMBASE, and Cochrane Library databases to identify all relevant studies using the items “frailty,” “weak,” “risk factors,” and “predictive factors” and compared their results. The aging population (≥65 years old) was divided into 2 groups, a “frailty group” and a “robust control group,” and then the characteristics, lifestyles, and comorbidities were compared. Results: We compared the influence of baseline and concomitant diseases on frailty in the elderly respectively, and the analysis of the influence of baseline on frailty found that increasing age, lower weight, female sex, living alone, low levels of exercise, polypharmacy, higher education level, smoking, drinking, malnutrition, and lower vitamin D levels were associated with aging individuals being more likely to experience frailty. The data about concomitant diseases had shown that diabetes, hearing dysfunction, cognitive impairment, poor sleep, a history of falls, pain, and depression can increase the risk of frailty among the elderly population. Conclusion: Characteristics, comorbidities, and lifestyle factors can impact the occurrence of frailty, and relevant influencing factors should be considered.

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Prevalence of cognitive impairment in Chinese older inpatients and its relationship with 1-year adverse health outcomes: a multi-center cohort study

Cited by 20 publications

References 69 publications

Gender Characteristics of Postoperative Cognitive Dysfunction in Patients Undergoing Coronary Artery Bypass Grafting

Gender Characteristics of Postoperative Cognitive Dysfunction in Patients Undergoing Coronary Artery Bypass Grafting

Mental Fatigue Is Associated with Subjective Cognitive Decline among Older Adults

Risk factors for frailty in older adults

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