Prevalence of colorectal cancer and advanced adenoma in patients with acute diverticulitis: implications for follow-up colonoscopy

Tehranian, Shahrzad; Klinge, Matthew; Saul, Melissa; Morris, Michele; Diergaarde, Brenda; Schoen, Robert E.

doi:10.1016/j.gie.2019.08.044

Cited by 32 publications

(26 citation statements)

References 38 publications

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“… 5 Colorectal advanced adenoma (CAA) refers to any CA ≥ 1 cm in diameter or villous or serrated adenoma of high-risk pathological type, and/or high-grade intraepithelial tumor. 6 At a median follow-up, researchers found that participants with CAA were more likely to develop CRC than participants without CAA (rate, 2.7 [95% CI, 1.9–3.7]; P < 0.001). 7 Therefore, screening and resection of CAA should be an effective way to reduce CRC mortality.…”

Section: Introductionmentioning

confidence: 99%

Serum Untargeted UHPLC-HRMS-Based Lipidomics to Discover the Potential Biomarker of Colorectal Advanced Adenoma

Zhu¹,

Wang²,

Nong³

et al. 2021

CMAR

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Section: Introductionmentioning

confidence: 99%

Serum Untargeted UHPLC-HRMS-Based Lipidomics to Discover the Potential Biomarker of Colorectal Advanced Adenoma

Zhu¹,

Wang²,

Nong³

et al. 2021

CMAR

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“…The incidence of CRC in diverticulitis patients is therefore higher than the incidence encountered in colonoscopy screening programs (which is approximately of 0.8% [28]). A recent observational study with a good sample size reported that patients with diverticulitis were at significantly higher risk (prevalence of 2.9%) for CRC than patients from a local colonoscopy register (prevalence of 0.3%) [29]. Moreover, patients who undergo colonoscopy are already considered at higher risk for CRC, as they were entered into the program due to either positive fecal test and/or red flags for CRC.…”

Section: Colonoscopy After Diverticulitismentioning

confidence: 99%

Colonoscopy after Diverticulitis

Meyer¹,

Ris²

2022

Diverticular Disease of the Colon - Recent Knowledge of Physiopathology, Endoscopic Approaches, Clinical and Surgical Treatment

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Patients suffering from diverticulitis are at increased risk for colorectal cancer and should undergo colonoscopy to rule out colorectal cancer. The prevalence of colorectal cancer in this population was estimated to range between 1.9 and 2.3%. This prevalence is higher in patients with complicated diverticulitis (abscess, perforation) and ranges between 6.1% and 7.9%. Therefore, interval colonoscopy is strongly recommended after an episode of complicated diverticulitis. The prevalence of colorectal cancer is lower in patients with uncomplicated diverticulitis and approaches the prevalence from screened populations. In patients with uncomplicated diverticulitis, the indication for colonoscopy is still a matter of debate and should be done on a case-by-case basis.

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“…One might argue that the percentages of colon cancer in uncomplicated diverticulitis are relatively low but are higher than those seen in a general screening population[ 82 , 83 ]. Furthermore, the yield is higher than the one obtained for evaluation of occult rectal bleeding.…”

Section: Diverticulitis Colorectal Cancer and The Role Of Endos-copmentioning

confidence: 99%

Update on the management of sigmoid diverticulitis

Hanna

Kaiser

2021

WJG

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Diverticular disease and diverticulitis are the most common non-cancerous pathology of the colon. It has traditionally been considered a disease of the elderly and associated with cultural and dietary habits. There has been a growing evolution in our understanding and the treatment guidelines for this disease. To provide an updated review of the epidemiology, pathogenesis, classification and highlight changes in the medical and surgical management of diverticulitis. Diverticulitis is increasingly being seen in young patients (< 50 years). Genetic contributions to diverticulitis may be larger than previously thought. Potential similarities and overlap with inflammatory bowel disease and irritable bowel syndrome exist. Computed tomography imaging represents the standard to classify the severity of diverticulitis. Modifications to the traditional Hinchey classification might serve to better delineate mild and intermediate forms as well as better classify chronic presentations of diverticulitis. Non-operative management is primarily based on antibiotics and supportive measures, but antibiotics may be omitted in mild cases. Interval colonoscopy remains advisable after an acute attack, particularly after a complicated form. Acute surgery is needed for the most severe as well as refractory cases, whereas elective resections are individualized and should be considered for chronic, smoldering, or recurrent forms and respective complications (stricture, fistula, etc . ) and for patients with factors highly predictive of recurrent attacks. Diverticulitis is no longer a disease of the elderly. Our evolving understanding of diverticulitis as a clinical entity has led into a more nuanced approach in both the medical and surgical management of this common disease. Non-surgical management remains the appropriate treatment for greater than 70% of patients. In individuals with non-relenting, persistent, or recurrent symptoms and those with complicated disease and sequelae, a segmental colectomy remains the most effective surgical treatment in the acute, chronic, or elective-prophylactic setting.

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Prevalence of colorectal cancer and advanced adenoma in patients with acute diverticulitis: implications for follow-up colonoscopy

Cited by 32 publications

References 38 publications

Serum Untargeted UHPLC-HRMS-Based Lipidomics to Discover the Potential Biomarker of Colorectal Advanced Adenoma

Serum Untargeted UHPLC-HRMS-Based Lipidomics to Discover the Potential Biomarker of Colorectal Advanced Adenoma

Colonoscopy after Diverticulitis

Update on the management of sigmoid diverticulitis

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