Prevalence of Combined Lipid Abnormalities in Brazilian Adolescents and Its Association with Nutritional Status: Data from the Erica Study

Abstract

Background: Cardiovascular diseases are the leading cause of death in Brazil and worldwide. The growing incidence of obesity in children and adolescents and its association with lipid abnormalities may worsen this scenario, mainly in developing countries where obesity has reached epidemic levels. Dyslipidemias have several patterns, and the combination of some lipid abnormalities may have higher atherogenic potential. Objectives: To evaluate the prevalence of single or multiple combined lipid abnormalities in adolescents and its association with nutritional status assessed by body mass index. Methods: Data were obtained from the Study of Cardiovascular Risks in Adolescents (ERICA), a school-based, national representative study with Brazilian adolescents between 12 and 17 years of age. Adolescents whose lipid profiles were available were included, and lipid abnormalities were defined as LDL-C ≥ 100 mg/dL, HDL-C < 45 mg/dL, and tryglicerides (TG) ≥ 100 mg/dL. We assessed the prevalence of single or combined lipid abnormalities and correlated this nutritional status with body mass index of low weight, normal, overweight, and obesity. Results: A total of 38,069 adolescents were included, with more than 24,000 of them presenting at least one lipid abnormality (64.7%), and 3.7% showing alterations in all of them. The most prevalent combination was high TG with low HDL-C levels. The higher the BMI, the more lipid abnormalities were found. Conclusions: In this large and representative sample of Brazilian adolescents, the majority had at least one lipid abnormality. Higher BMI was associated with a higher prevalence of combined lipid abnormalities. Highlights:-There is a high prevalence of Brazilian adolescents with dyslipidemias.-BMI was associated with a higher prevalence of combined lipid abnormalities.-BMI can be considered as an indicator of the diagnosis of dyslipidemia in adolescents.

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“…Combined evidence from cohort studies indicates that, even in children, there is a direct relationship between increased weight and higher blood lipid levels. In our study, higher TG and LDL-C levels were linked to higher weight scores, which concur with data reported in other populations [13].…”

Prevalence and Predictors of Dyslipidemia in Children and Adolescents in Yazd Greater Area, Yazd, Iran

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“…The BMI level has a positive relationship with the lipid abnormalities and prevalence of combined lipid abnormalities. The BMI can be considered as an indicator for the diagnosis of dyslipidemia in adolescents (2). In this regard, another study conducted in Denmark (North-Europe) revealed that children and adolescents with obesity had increased concentrations of circulating lipids and exhibited an increased prevalence of dyslipidemia (8).…”