Prevalence of complications associated with Alzheimer disease

Alhazzani, Adel; Alqahtani, Mohammed; Alshbriqe, A.; Awwadh, A.; Alyami, Turki Ali; Alshomrani, M.; Mostafa, Ossama A.

doi:10.1016/j.jns.2017.08.892

Cited by 3 publications

(3 citation statements)

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“…24,2 Alhazzani et al conducted a cross-sectional study in Saudi Arabia and revealed that AD caregivers tended to be sons or daughters (69.1%) or spouses (11.8%) and that the majority of caregivers had poor quality of sleep. 27 The global PSQI score positively correlated with the duration of caregivers' daily stay with AD patients (r=0.272, p=0.004), but it did not correlate significantly with either the caregivers' or the patients' ages. Alshammari et al conducted a study in Saudi Arabia to discover the characteristics of informal caregivers of elderly patients; identify the socioeconomic, psychological, and physical consequences experienced by informal caregivers; and measure their burdens and needs.…”

Section: Discussionmentioning

confidence: 91%

Quality of sleep among caregivers of Alzheimer disease patients: cross-sectional study from Saudi Arabia

Alhazzani

Alqahtani

2021

Int J Community Med Public Health

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Background: Alzheimer’s disease (AD) is the most common cause of dementia and represents a major health burden. Characterized by gradual decline in cognitive function, leading to dependency and changes in behavior and personality. Patients with AD need continuous care, which may affect the caregiver’s quality of life, including sleep quality. The aim of this study was to assess sleep quality among AD patients’ caregivers and its determinants in Aseer region, Saudi Arabia.Methods: A descriptive cross-sectional study was conducted among 110 caregivers of AD patients at Abha Mental Health Hospital. The caregivers’ sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). A global PSQI cutoff value of 5 or higher was considered as indicative of poor sleep quality.Results: Female caregivers’ constituted 53.6% of the sample, and 50% were below the age of 40 years. The majority of the caregivers (64.5%) reported that they had experienced sleep disturbances during past month and 10% needed medication approximately three or more times a week to help them sleep. Almost two-thirds of the caregivers (60%) spent more than 10 hours daily with their patients. Regarding sleep hygiene, 40.9% of the caregivers rated their sleep quality as poor and only 10.9% had good sleep quality.Conclusions: The burden on caregivers of AD patients is considerable and often under-recognized; in particular; most caregivers in the Saudi population were young and of working age. Poor sleep quality affected the caregivers’ day life activities but typically remained undertreated.

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Section: Discussionmentioning

confidence: 91%

Quality of sleep among caregivers of Alzheimer disease patients: cross-sectional study from Saudi Arabia

Alhazzani

Alqahtani

2021

Int J Community Med Public Health

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“…Men were markedly observed to be associated with misplacing possessions and low background for pneumonia; these conditions were reported as the main cause for hospital admission. The attention given to these factors is very important for an AD patient to prevent such complications and to help in early therapy to minimize the level of morbidity and mortality [242].…”

Section: Pathological Conditions Of Citrullinationmentioning

confidence: 99%

An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders

Alghamdi

Alasmari

Assiri

et al. 2019

Journal of Immunology Research

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A protein undergoes many types of posttranslation modification. Citrullination is one of these modifications, where an arginine amino acid is converted to a citrulline amino acid. This process depends on catalytic enzymes such as peptidylarginine deiminase enzymes (PADs). This modification leads to a charge shift, which affects the protein structure, protein-protein interactions, and hydrogen bond formation, and it may cause protein denaturation. The irreversible citrullination reaction is not limited to a specific protein, cell, or tissue. It can target a wide range of proteins in the cell membrane, cytoplasm, nucleus, and mitochondria. Citrullination is a normal reaction during cell death. Apoptosis is normally accompanied with a clearance process via scavenger cells. A defect in the clearance system either in terms of efficiency or capacity may occur due to massive cell death, which may result in the accumulation and leakage of PAD enzymes and the citrullinated peptide from the necrotized cell which could be recognized by the immune system, where the immunological tolerance will be avoided and the autoimmune disorders will be subsequently triggered. The induction of autoimmune responses, autoantibody production, and cytokines involved in the major autoimmune diseases will be discussed.

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“…3 Alzheimer's disease is caused by several factors, such as infections, cytotoxicity of amyloid b-protein, increasing age (aging), and genetic characteristics. 4,5 Alzheimer's disease has complications such as depression, hallucinosis (psychiatric disturbances), sleep disturbance, difficulty speaking, pneumonia, constipation or diarrhea, malnutrition or dehydration, and dental problems, [6][7][8] in addition to cognitive and functional decline. 9 Aging is marked by a progressive loss of human cells and tissues because of genetic and environmental factors and oxidative damage.…”

Section: Introductionmentioning

confidence: 99%