Prevalence of Complications of Sickle Cell Disease at Makkah Al-Mukaramah, Saudi Arabia, 2017

Alkot, Mohammad; Almaghrabi, Walaa A; Al-Najdi, Noura; Al-Otaibi, Mohammad; Shatla, Mokhtar; Abdelbaki, Hossam

doi:10.21767/2386-5180.1000226

Cited by 16 publications

(20 citation statements)

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“…In our study, there was no major difference regarding the prevalence of SCA in terms of gender. This finding has been consistent throughout the literature [ 5 ]. Although the study showed no significant difference with regard to nationality, a recent multicenter study from Makkah revealed that a higher number of patients with SCA in their sample were Saudi nationals [ 5 ].…”

Section: Discussionsupporting

confidence: 93%

“…It led to the introduction of nationwide screening methods to establish the disease clinical spectrum and genotype variations throughout KSA [ 4 ]. A study conducted in Makkah found that 108 patients were diagnosed with SCD out of 45,682 young adults and children living in the western region of KSA [ 5 ]. Regarding the regional distribution of SCD in KSA, the highest prevalence has been found in the Eastern Province, followed by the western and the central regions; no cases were found in the northern region [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study

Alzahrani¹,

Fallatah²,

Al-Haddad³

et al. 2021

Cureus

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Background and objective Sickle cell anemia (SCA) is one of the common genetic diseases in the Kingdom of Saudi Arabia (KSA). This disease results from a genetic mutation that causes malformation of the red blood cells (RBCs), leading to various systemic complications, including vaso-occlusive crisis (VOC), acute chest syndrome (ACS), osteomyelitis, avascular necrosis (AVN), and stroke, to name a few. The leading cause of mortality in SCA is these systemic complications rather than the disease itself. Understanding the risk factors of these complications can help reduce mortality in these patients and improve their quality of life. In this study, we aimed to determine the risk factors of SCA complications among pediatric patients with SCA at King Abdulaziz University Hospital (KAUH) in Jeddah, KSA. Methods This retrospective study was carried out from January 2012 till June end 2019. It was conducted among pediatric patients with SCA. Patients were screened for eligibility, and we excluded those with thalassemia and those who had a medical history of chronic diseases. Data were collected from patients’ electronic medical records. Results The study included 102 pediatric patients with SCA; their mean age was 7.88 ±4.22 years; almost half of them were females (56%) and 44% were males. The dominant body mass index (BMI) classification among them was normal (49%). Urinary tract infection (UTI) was the most common complication with 38 cases followed by VOC with 32 cases. Other complications observed were ACS (25.5%) followed by stroke (15.7%). HbSS was the most prominent genotype among these patients, and it was associated with a higher rate of complications. However, there was no significant relationship between genotype and patients developing complications. Finally, patients with high white blood cell (WBC) counts, elevated systolic blood pressure (SBP), and hypoxia developed more complications, and there was a significant relationship between these conditions and the development of complications (p<0.05). Conclusion Based on our findings, patients with high WBC count, elevated SBP, and hypoxia are at greater risk of developing complications. Accordingly, healthcare providers should consider putting in place all measures required to provide a good quality of life for these patients, including raising awareness about the risk factors that lead to these complications, appropriate immunizations, and precautionary measures to promote these patients' welfare.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study

Alzahrani¹,

Fallatah²,

Al-Haddad³

et al. 2021

Cureus

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“…A recent study conducted in the Makkah region of Saudi Arabia reported that infection (but not necessarily SBI) was the second most common complication leading to admission in children with SCD, accounting for 9% of admissions but was dwarfed by the veno-occlusive disease, which accounted for 56% of admissions. 21 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Serious Bacterial Infections in Children With Sickle Cell Disease at King Abdulaziz Hospital, Al Ahsa

Alsaif

Abdulbaqi

Noaim

et al. 2020

Mediterr J Hematol Infect Dis

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Aim: The main aim was to report the prevalence and severity of serious bacterial infections (SBI) in children with sickle cell disease at King Abdulaziz Hospital, Al Ahsa, Saudi Arabia to aid in determining whether outpatient management of such cases is appropriate. Methods: We conducted a retrospective chart review of febrile children less than 14 years of age admitted with sickle cell disease 2005 through 2015. Results: During 320 admissions, 25 children had SBIs (8%) including pneumonia (n=11), osteomyelitis (n=8), bacteremia (n=3, all with Salmonella species) and UTI (n=3). All recovered uneventfully. Conclusion: It appears that in the current era, less than 10% of febrile children with sickle cell disease in our center are diagnosed with a SBI. Over an 11-year period, there were no sequelae or deaths from SBI. Given these excellent outcomes, outpatient ceftriaxone should be considered for febrile well appearing children with sickle cell disease if they have no apparent source and parents are judged to be reliable.

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“…SCD is associated with significant morbidity and mortality. Patients with SCD carry more risk of developing complications including vasoocclusive crisis (VOC), fatal acute chest syndrome, splenic infarction, hemolytic crisis and osteomyelitis [2].…”

Section: Introductionmentioning

confidence: 99%

Salmonella Spondylodiscitis in a Patient with Sickle Cell Disease - Case Report and Literature Review

Al¹,

Renjit²,

Al³

et al. 2020

J Musculoskelet Disord Treat

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Prevalence of Complications of Sickle Cell Disease at Makkah Al-Mukaramah, Saudi Arabia, 2017

Cited by 16 publications

References 0 publications

Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study

Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study

Prevalence of Serious Bacterial Infections in Children With Sickle Cell Disease at King Abdulaziz Hospital, Al Ahsa

Salmonella Spondylodiscitis in a Patient with Sickle Cell Disease - Case Report and Literature Review

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