Prevalence of congenital heart disease assessed by echocardiography in 2067 consecutive newborns

Ishikawa, Takamichi; Iwashima, Satoru; Ohishi, Akira; Nakagawa, Yuichi; Ohzeki, Takehiko

doi:10.1111/j.1651-2227.2011.02248.x

Cited by 45 publications

(39 citation statements)

References 28 publications

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“…The prevalence of CHD may range from 4 to 50 per 1000 live births depending on the diagnostic method used and subject´s age [12]. CHD prevalence is higher, about 50/1.000, using echocardiography method and during the first months of life as we did.…”

Section: Discussionmentioning

confidence: 73%

Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study

et al. 2017

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ObjectiveTo report the echocardiographic evaluation of 103 infants with presumed congenital Zika syndrome.MethodsAn observational retrospective study was performed at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil. 103 infants with presumed congenital Zika syndrome. All infants had microcephaly and head computed tomography findings compatible with congenital Zika syndrome. Zika IgM antibody was detected in cerebrospinal fluid samples of 23 infants. In 80 infants, the test was not performed because it was not available at that time. All infants had negative serology for HIV, syphilis, rubella, cytomegalovirus and toxoplasmosis. A complete transthoracic two-dimensional, M-mode, continuous wave and pulsed wave Doppler and color Doppler echocardiographic (PHILIPS HD11XE or HD15) examination was performed on all infants.Results14/103 (13.5%) echocardiograms were compatible with congenital heart disease: 5 with an ostium secundum atrial septal defect, 8 had a hemodynamically insignificant small apical muscular ventricular septal defect and one infant with dyspnea had a large membranous ventricular septal defect. The echocardiograms considered normal included 45 infants with a persistent foramen ovale and 16 with a minimum patent ductus arteriosus.ConclusionsPreliminarily this study suggests that congenital Zika syndrome may be associated with an increase prevalence of congenital heart disease. However the types of defects noted were septal defects, a proportion of which would not be hemodynamically significant.

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Section: Discussionmentioning

confidence: 73%

Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study

et al. 2017

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“…Iris flocculi were reported in association with ACTA2 mutations associated with thoracic aortic aneurysms (Disabella et al, 2011) but were also seen in two children with the multi-system phenotype described here, and are a further helpful clinical clue. Persistent ductus arteriosus is a common cardiac defect [1.4% live births (Ishikawa et al, 2011)]; an important clinical message is that the eyes should be examined in these patients. Intimal hyperplasia in clinically and angiographically unaffected arteries in three of our patients emphasizes the systemic nature of the vasculopathy associated with ACTA2 mutations and therefore potential involvement of any organ system dependent on smooth muscle cell function.…”

Section: Discussionmentioning

confidence: 99%

A novel distinctive cerebrovascular phenotype is associated with heterozygous Arg179 ACTA2 mutations

Munot

Saunders

Milewicz

et al. 2012

Brain

113

121

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Mutations in the ACTA2 gene lead to diffuse and diverse vascular diseases; the Arg179His mutation is associated with an early onset severe phenotype due to global smooth muscle dysfunction. Cerebrovascular disease associated with ACTA2 mutations has been likened to moyamoya disease, but appears to have distinctive features. This study involved the analysis of neuroimaging of 13 patients with heterozygous missense mutations in ACTA2 disrupting Arg179. All patients had persistent ductus arteriosus and congenital mydriasis, and variable presentation of pulmonary hypertension, bladder and gastrointestinal problems associated with this mutation. Distinctive cerebrovascular features were dilatation of proximal internal carotid artery, occlusive disease of terminal internal carotid artery, an abnormally straight course of intracranial arteries, and absent basal 'moyamoya' collaterals. Patterns of brain injury supported both large and small vessel disease. Key differences from moyamoya disease were more widespread arteriopathy, the combination of arterial ectasia and stenosis and, importantly, absence of the typical basal 'moyamoya' collaterals. Evaluation of previously published cases suggests some of these features are also seen in the ACTA2 mutations disrupting Arg258. The observation that transition from dilated to normal/stenotic arterial calibre coincides with where the internal carotid artery changes from an elastic to muscular artery supports the hypothesis that abnormal smooth muscle cell proliferation caused by ACTA2 mutations is modulated by arterial wall components. Patients with persistent ductus arteriosus or congenital mydriasis with a label of 'moyamoya' should be re-evaluated to ensure the distinctive neuroimaging features of an ACTA2 mutation have not been overlooked. This diagnosis has prognostic and genetic implications, and mandates surveillance of other organ systems, in particular the aorta, to prevent life-threatening aortic dissection.

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“…[2] A few studies have assessed the prevalence of CHD at birth by the echocardiographic screening of an in-hospital population. [34] No large-sample, population-based study on CHD using echocardiography has been conducted in Langfang district.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Congenital Heart Disease among Infants from 2012 to 2014 in Langfang, China

Sun

Ding

Zhang

et al. 2017

Chinese Medical Journal

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Background:Congenital heart disease (CHD) is the most common congenital malformations with high mortality and morbidity. The prevalence of CHD reported previously ranged from 4 per 1000 live births to 50 per 1000 live births. In this cross-sectional study, we aimed to document the prevalence of CHD in Langfang district of Hebei Province, China by analyzing data collected by hospitals located in 11 the counties of the district, as supported by a public health campaign.Methods:A total of 67,718 consecutive 3-month-old infants were included from July 19, 2012 to July 18, 2014. Structural abnormalities were diagnosed based on echocardiography findings, including two-dimensional and color Doppler echocardiography results.Results:Of the 67,718 infants, 1554 were found to have cardiac structural abnormalities. The total prevalence of CHD was 22.9 per 1000 live births, a value significantly higher than the previously reported prevalence of 8 cases per 1000 live births. The top five most common cardiac abnormalities were as follows: atrial septal defect (ASD, 605 cases, 8.93‰); ventricular septal defect (550 cases, 8.12‰); patent ductus arteriosus (228 cases, 3.37‰); pulmonary stenosis (66 cases, 0.97‰); and tetralogy of Fallot (32 cases, 0.47‰). The CHD prevalence differed by gender in this study (χ2 = 23.498, P < 0.001), and the majority of ASD cases were females. Regional differences in prevalence were also found (χ2 = 24.602, P < 0.001); a higher prevalence was found in urban areas (32.2 cases per 1000 live births) than in rural areas (21.1 cases per 1000 live births). There was a significant difference in the prevalence of CHD in preterm versus full-term infants (χ2 = 133.443, P < 0.001). Prevalence of CHD in infants of maternal aged 35 years or over was significantly higher (χ2 = 86.917, P < 0.001).Conclusions:The prevalence of CHD in Langfang district was within the range reported using echocardiography. Echocardiography can be used to early diagnose the CHD.

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Prevalence of congenital heart disease assessed by echocardiography in 2067 consecutive newborns

Abstract: This prospective study using echocardiography for all newborns shows a higher prevalence of CHD than almost all of the previous studies.

Cited by 45 publications

References 28 publications

Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study

Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study

A novel distinctive cerebrovascular phenotype is associated with heterozygous Arg179 ACTA2 mutations

Prevalence of Congenital Heart Disease among Infants from 2012 to 2014 in Langfang, China

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