Prevalence of Congenital Hypothyroidism in Isfahan, Iran: Results of a Survey on 20,000 Neonates

Hashemipour, Mahin; Amini, Massoud; Iranpour, Ramin; Sadri, Gholam Hossein; Javaheri, Narges; Haghighi, S; Hovsepian, Silva; Javadi, Abbasali; Nematbakhsh, Mahdi; Sattari, G

doi:10.1159/000079392

Cited by 47 publications

(52 citation statements)

References 54 publications

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“…In another study conducted in England in 1982, the incidence of congenital hypothyroidism was reported as 1/3937 and higher in babies of Asian mothers compared to other races (17). The higher incidence in the Asian race was also observed in New York (Table 1) (24). According to our results, the incidence of congenital hypothyroidism in Hormozgan province is much higher than the global average, and is in average ranking compared to Iran's.…”

Section: Discussionsupporting

confidence: 62%

Frequency of Congenital Hypothyroidism in Hormozgan Province, Iran

Nazemi¹,

Hamedi²,

Rashidi³

et al. 2018

Acta Healthmedica

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Background: Congenital hypothyroidism, defined as thyroid hormone deficiency at birth, is one of the most common preventable causes of mental retardation. Methods: This study was a cross sectional investigation conducted prospectively on 45,799 live births from September 2010 to February 2012 in the Hormozgan province, Iran, who participated in congenital hypothyroidism screening. In accordance with national protocol, blood samples were taken from the heels of the newborns 3-7 days after their birth. Neonatal TSH values less than 5 mIU / L were considered as normal; TSH values greater than or equal to 5 mIU/L were considered as suspicious, and an immediate report was made to the Focal Point of the newborn's birth place. Descriptive statistics including mean, frequency and percentage were used to present the results. SPSS version 20 and t-test was used for comparison of continuous quantitative variables (age and weight) and Chi-Square test was used to determine the qualitative relationship between variables.w Results: Out of 45,799 infants in the initial study, Blood TSH was ≥5 mIU/L in 1,241 infants (2.7%). Of these 1,241 infants, 1,159 cases (93.3%) had TSH between 5-9.9 mIU/L, 39 infants (3.1%) between 10-19.9 mIU/L, and 43 infants (3.46%) ≥20 mIU/L. The incidence of congenital hypothyroidism in the province was estimated at 1/715 live births. The mean TSH of 64 infants suffering from congenital hypothyroidism was reported 36.8±34 mIU/L (10-100). The mean age of the infants at the time of admission for second sampling was 7.5±6.5 (3-30) days. Conclusion: In view of the high incidence of congenital hypothyroidism in Hormozgan province, several times more prevalent than many areas of the world, the continuation and strengthening of the neonatal screening program appears indispensable.

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Section: Discussionsupporting

confidence: 62%

Frequency of Congenital Hypothyroidism in Hormozgan Province, Iran

Nazemi¹,

Hamedi²,

Rashidi³

et al. 2018

Acta Healthmedica

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“…[7] The data showed that the recall rate is high as compared with that in some countries of the region, such as Indonesia and Thailand. [8,9] In some European countries, the recall rate was between 0.16% and 2.7%.…”

Section: Discussionmentioning

confidence: 99%

Neonatal thyroid screening in a mild iodine deficiency endemic area in Iran

Najafi¹,

Khodaee²,

Bahari³

et al. 2008

Indian J Med Sci

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“…From May 2002, T4 and TSH serum concentrations of all 3- to 7-day-old newborns, born in all 17 hospitals of the city of Isfahan, were measured by radioimmunoassay (RIA) and immunoradiometric assay (IRMA), respectively, using Kavoshyar (Iran, Tehran) kits. The newborns with abnormal screening results were re-examined and newborns with an abnormal T4 and TSH level at second measurement were diagnosed as being CH patients and received treatment and regular follow-up [20]. …”

Section: Methodsmentioning

confidence: 99%

“…With an incidence of 1/370, CH is not a rare condition in the Province of Isfahan [20], and the families from this region form a large risk population for thyroid abnormalities. Taking all the previously demonstrated data into consideration, we aimed to investigate whether an increased incidence of thyroid abnormalities could be shown by ultrasonography among first-degree relatives of CH patients.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Abnormalities among First-Degree Relatives of Children with Congenital Hypothyroidism: An Ultrasound Survey

Adibi¹,

Haghighi²,

Hosseini³

et al. 2008

Horm Res Paediatr

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Background: Congenital hypothyroidism (CH) is caused by thyroid dysgenesis and dyshormonogenesis. Evidence suggests the presence of genetic factors in both types of pathogenesis. We investigated whether an increased incidence of thyroid abnormalities could be shown by ultrasonography among first-degree relatives of children with CH. Material and Methods: In this case-control study the presence of both developmental and non-developmental thyroid abnormalities was studied among first-degree relatives of CH patients and healthy children. Assessments included neck ultrasonography and thyroid function tests. The data obtained from parents, siblings and children were compared in the case and control groups. Results: In the case group, 92 patients, 172 parents and 57 siblings, and in the control group, 82 healthy children, 160 parents and 39 siblings were studied. Thyroid developmental abnormalities were more prevalent among parents (3.5 vs. 0%, p = 0.03) and siblings (10.5 vs. 0, p = 0.01) of CH patients than the control group. Non-developmental abnormalities were not significantly different between the case and control groups (17 vs. 13%, p = 0.3). Conclusion: Thyroid developmental abnormalities were more prevalent among parents and siblings of CH patients than the control group, confirming the familial component of this entity.

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Prevalence of Congenital Hypothyroidism in Isfahan, Iran: Results of a Survey on 20,000 Neonates

Cited by 47 publications

References 54 publications

Frequency of Congenital Hypothyroidism in Hormozgan Province, Iran

Frequency of Congenital Hypothyroidism in Hormozgan Province, Iran

Neonatal thyroid screening in a mild iodine deficiency endemic area in Iran

Thyroid Abnormalities among First-Degree Relatives of Children with Congenital Hypothyroidism: An Ultrasound Survey

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