Prevalence of Contraindications and Prescription of Pharmacologic Therapies for Gout

Rilonacept (interleukin‐1 trap) for prevention of gout flares during initiation of uric acid–lowering therapy: Results from a phase III randomized, double‐blind, placebo‐controlled, confirmatory efficacy study

“…The current standards, NSAIDs and colchicine, are associated with AEs and contraindications that limit their use. As many as 90% of patients with gout may have a contraindication to NSAIDs (hypertension, cardiovascular disease, chronic kidney disease, and gastroesophageal disease), and up to 40% may have a relative contraindication to colchicine (chronic kidney disease and chronic hepatitis) (38). Of note, renal impairment does not appear to alter rilonacept exposure (36).…”

“…These data, the first from among 2 confirmatory efficacy studies and a large phase III safety study, suggest that for some patients, blockade of IL-1 by rilonacept may be an effective alternative to current approaches of gout flare management. Gout flare prevention during the initiation of ULT remains an important need in gout management, not least because of the limitations associated with currently available drugs (15,18,38). The current standards, NSAIDs and colchicine, are associated with AEs and contraindications that limit their use.…”

Current and Emerging Therapies for Gout

“…Despite gout being a disease of antiquity, unfortunately it still continues to be an undertreated disease [3]. This is in part not only due to lack of proper use of available medications but also due to the side effects or perceived side effects limiting their use.…”

“…The prevalence of hyperuricemia alone amongst US adults is 21.4 % or about 43.3 million individuals [2]. Despite the rising prevalence, current therapies are often limited due to side effects, conflicting comorbidities (such as cardiovascular disease, diabetes mellitus, hypertension, chronic kidney disease, metabolic syndrome), and drug-drug interactions [3].…”

An old disease with new insights: Update on diagnosis and treatment of gout

“…Patients with gout frequently have comorbidities, including diabetes, obesity, hypertension, chronic kidney disease (CKD), and cardiovascular disease (23,90,91). Gout requires lifelong therapy, concurrent with management of comorbidities.…”